Paid Clinical Trials in Charleston, SC

As of September 2026, 676 paid clinical trials are recruiting in Charleston, South Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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597 clinical trials

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Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy

for Epilepsy in Children

Sites in Charleston +2 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 13 - 17

Code: NCT06608966·Recruiting·Listed Sep 2024

Apply to this trial

Induction in the Dark

for Anesthesia Induction

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 2 - 6

Code: NCT06144177·Phase 4·Recruiting·Listed Nov 2023

Apply to this trial

CBD for Breast Cancer Primary Tumors

for Breast Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06148038·Phase 1·Recruiting·Listed Nov 2023

Apply to this trial

Emotional Recovery Post-Stroke

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT06782321·Recruiting·Listed Jan 2025

Apply to this trial

Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

Sites in Charleston +59 more locations

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

Apply to this trial

Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

Sites in Charleston +21 more locations

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting·Listed Feb 2022

Apply to this trial

E-cigarette Cessation in Adults Who Co-use Cannabis

for Nicotine Dependence

Sites in Charleston, Lancaster & Pickens

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06688539·Phase 4·Recruiting·Listed Nov 2024

Apply to this trial

Examining Whether Project Support Works

for Parent-Child Relations

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 6 - 13

Code: NCT06963554·Recruiting·Listed May 2025

Apply to this trial

The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

for Head and Neck Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05811936·Recruiting·Listed Apr 2023

Apply to this trial

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Charleston, Boiling Springs +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

Apply to this trial

ERP to Improve Functioning in Veterans With OCD

for Obsessive Compulsive Disorder (OCD)

Sites in Charleston +18 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05240924·Recruiting·Listed Feb 2022

Apply to this trial

tFUS Induced Transient Scotoma for Individual Dosing

for Healthy

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06426498·Recruiting·Listed May 2024

Apply to this trial

Cognitive Decline Following Deep Brain Stimulation

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05822388·Recruiting·Listed Apr 2023

Apply to this trial

GLP1 Fasting Status and Gastric Retention Using Gastric Ultrasound

for Gastric Retention

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07251803·Recruiting·Listed Nov 2025

Apply to this trial

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

Sites in Charleston, Orangeburg +34 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting·Listed May 2022

Apply to this trial

IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06582784·Recruiting·Listed Sep 2024

Apply to this trial

Accelerated iTBS for Post Partum Depression

for Post Partum Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: Female·Age: 18 - 50

Code: NCT03417960·Recruiting·Listed Jan 2018

Apply to this trial

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Charleston, Boiling Springs +81 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Weekly Isotretinoin vs Tetracycline for Moderate Acne

for Acne Vulgaris

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 12+·Accepts healthy volunteers

Code: NCT06225570·EARLY_Phase 1·Recruiting·Listed Jan 2024

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Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07076212·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Tele-PCIT for Healthy Relationships in Families At-Risk

for Disruptive Behavior

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 2 - 7

Code: NCT07225010·Recruiting·Listed Nov 2025

Apply to this trial

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Charleston +14 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

Apply to this trial

Weight Loss and ExeRcise for Post-stroke Veterans

for Stroke

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 40 - 80

Code: NCT06322030·Recruiting·Listed Mar 2024

Apply to this trial

Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

for Stage III Ovarian Cancer

Drug: Niraparib

Sites in Charleston +58 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05659381·Phase 3·Recruiting·Listed Dec 2022

Apply to this trial

COAST Therapy in Advanced Solid Tumors and Prostate Cancer

for Prostate Cancer Recurrent

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05036226·Phase 1, Phase 2·Recruiting·Listed Sep 2021

Apply to this trial

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

for Oropharyngeal Squamous Cell Carcinoma

Sites in Charleston +2 more locations

Sponsor: University of Florida

Sex: All·Age: 18+

Code: NCT05268614·Phase 2·Recruiting·Listed Mar 2022

Apply to this trial

Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

Sites in Charleston +25 more locations

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting·Listed Jul 2022

Apply to this trial

NeoCARD: Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer Patients

for Triple Negative Breast Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06845319·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

for Chronic Pain

1 location in Charleston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 21+

Code: NCT07116109·Recruiting·Listed Aug 2025

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Establishing Mobile Transcranial Magnetic Stimulation

for Treatment Resistant Major Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 22 - 80

Code: NCT06748209·Phase 4·Recruiting·Listed Dec 2024

Apply to this trial

Methadone in THA for Post-op Pain and Opioid Reduction

for Post Operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT07227064·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

Sites in Charleston +31 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting·Listed Mar 2022

Apply to this trial

Methadone in TKA for Post-op Pain and Opioid Reduction

for Post Operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT07226076·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Charleston +339 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

Apply to this trial

Advanced Fibrosis Detection for MASLD in Primary Care

for Metabolic Dysfunction-associated Steatotic Liver Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07159386·Recruiting·Listed Sep 2025

Apply to this trial

Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Charleston +53 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

Apply to this trial

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

for Posttraumatic Stress Disorder

Sites in Charleston +1 more location

Sponsor: Texas A&M University

Sex: All·Age: 18+

Code: NCT05959434·Phase 2·Recruiting·Listed Jul 2023

Apply to this trial

Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

for Post-Traumatic Stress Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 7 - 18

Code: NCT06332209·Recruiting·Listed Mar 2024

Apply to this trial

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Charleston, Myrtle Beach +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

Apply to this trial

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

Sites in Charleston +10 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting·Listed Dec 2024

Apply to this trial