Brain disorders Clinical Trials in Chicago, IL

As of July 2026, 82 paid clinical trials are recruiting for Brain disorders in Chicago, Illinois. Brain disorder trials span neurodegenerative diseases, stroke, traumatic brain injury, and neuromuscular conditions — testing both pharmacologic and rehabilitative approaches to slow progression and improve function. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

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86 clinical trials for Brain disorders

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Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 64

Code: NCT05051618·Recruiting·Listed Sep 2021

Apply to this trial

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 21 - 100

Code: NCT04312269·Recruiting·Listed Mar 2020

Apply to this trial

Characterization and Clinical Trial of a Variable Friction Shoe

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT06234124·Recruiting·Listed Jan 2024

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Nomad P-KAFO Study

for Cerebrovascular Accident

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89

Code: NCT05644522·Recruiting·Listed Dec 2022

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Neuromodulation and Neurorehabilitation for mTBI

for Mild Traumatic Brain Injury

Sites in Chicago +1 more location

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT03819608·Recruiting·Listed Jan 2019

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Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

Sites in Chicago +24 more locations

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting·Listed Jun 2023

Apply to this trial

MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)

for Stress, Psychological

Sites in Chicago, Bolingbrook & Buffalo Grove

Sponsor: University of Illinois at Chicago

Sex: All·Age: 45+

Code: NCT06002919·Recruiting·Listed Aug 2023

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rTMS to Improve Cognition in Parkinson's

for Parkinson's Disease

Sites in Chicago & Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 50+

Code: NCT03836950·Phase 1, Phase 2·Recruiting·Listed Feb 2019

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Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 21+

Code: NCT03401762·Recruiting·Listed Jan 2018

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Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

Sites in Chicago +10 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting·Listed Dec 2024

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Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

for Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT04477330·Recruiting·Listed Jul 2020

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Chicago, Evanston +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

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Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT05167786·Recruiting·Listed Dec 2021

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Hemodynamic ABI Monitor

for Traumatic Brain Injury (TBI)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 80

Code: NCT06725108·Recruiting·Listed Dec 2024

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Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06390930·Recruiting·Listed Apr 2024

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Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk

for Menopausal

1 location in Chicago

Sponsor: University of Chicago

Sex: Female·Age: 40 - 58

Code: NCT06965686·Recruiting·Listed May 2025

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Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

for LVAD

Sites in Chicago +3 more locations

Sponsor: International Consortium of Circulatory Assist Clinicians

Sex: All·Age: 18 - 100

Code: NCT06039176·Recruiting·Listed Sep 2023

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Chicago +40 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Chicago +27 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

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Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT07132775·Recruiting·Listed Aug 2025

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Impaired Interlimb Coordination During Locomotion in Individuals With Chronic Stroke: Contributors and Effect on Walking Function

for Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 25 - 90

Code: NCT07006818·Recruiting·Listed Jun 2025

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

Sites in Chicago +9 more locations

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting·Listed Nov 2021

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Inpatient Stroke Recovery Using Sensors

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04219670·Recruiting·Listed Jan 2020

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WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT07061691·Recruiting·Listed Jul 2025

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Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06598150·Recruiting·Listed Sep 2024

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Race-Based Stress and Cognitive Training for MCI

for Mild Cognitive Impairment

1 location in Chicago

Sponsor: Rosalind Franklin University of Medicine and Science

Sex: All·Age: 65+

Code: NCT06330844·Recruiting·Listed Mar 2024

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R01.Aim 2.Study 1: IsoReach

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06656754·EARLY_Phase 1·Recruiting·Listed Oct 2024

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Intermittent Hypoxia in Persons With Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06276634·Recruiting·Listed Feb 2024

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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

for Tuberous Sclerosis Complex

Sites in Chicago +9 more locations

Sponsor: Darcy Krueger

Sex: All·Age: 1 Day - 6 Months

Code: NCT05104983·Phase 2·Recruiting·Listed Nov 2021

Apply to this trial

Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)

for Alzheimer Disease

1 location in Chicago

Sponsor: Alzheimer's Disease and Related Disorders Association, Inc

Sex: All·Age: 18+

Code: NCT06170268·Recruiting·Listed Dec 2023

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

Sites in Chicago, Evanston +51 more locations

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting·Listed Aug 2021

Apply to this trial

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Chicago +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Predict Severe Traumatic Brain Injury

for Traumatic Brain Injury

Sites in Chicago +1 more location

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06966713·Recruiting·Listed May 2025

Apply to this trial

Motor rECovery witH eArly imagiNg In STroke

for Stroke

3 locations in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT04165616·Recruiting·Listed Nov 2019

Apply to this trial

Constraint Induced Movement Therapy for Walking in Individuals Post Stroke

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 21 - 75

Code: NCT03264261·Recruiting·Listed Aug 2017

Apply to this trial

Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation

for Traumatic Brain Injury

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 65

Code: NCT06589362·Recruiting·Listed Sep 2024

Apply to this trial

Safety and Feasibility of an ExoNET for Supination Assistance for Stroke Survivors

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT06655636·Recruiting·Listed Oct 2024

Apply to this trial

Error-enhanced Learning & Recovery in 2 & 3 Dimensions

for Stroke

3 locations in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05180786·Recruiting·Listed Jan 2022

Apply to this trial

Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06516458·Recruiting·Listed Jul 2024

Apply to this trial

A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

for Generalized Myasthenia Gravis

Sites in Chicago, Schaumburg +3 more locations

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07221838·Phase 4·Recruiting·Listed Oct 2025

Apply to this trial

Conditions in Brain disorders (Chicago, IL)

Stroke· 35 Multiple sclerosis· 14 Parkinson's disease· 12 Alzheimer's disease· 10 Mild cognitive impairment (MCI)· 9 ALS (amyotrophic lateral sclerosis)· 8 Dementia· 5 Traumatic brain injury (TBI)· 5 Myasthenia gravis· 5 Cognitive impairment / decline· 5 Epilepsy· 2 Huntington disease· 1 Essential tremor· 1