Paid Clinical Trials in Chicago, IL
As of July 2026, 2,157 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Chicago offers studies at sites including Northwestern University for conditions such as Breast Cancer, Heart Failure, Stroke, Obesity. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Chicago
Trials by drug in Chicago
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Newly added in Chicago
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
A Study to Characterize the Safety and Immunogenicity of AZD6489 in Participants 60 Years of Age and Older (ARIES)
Ocrevus Zunovo for MS: Mixed Methods
A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation
A Long-Term Safety Follow-up Registry for Patients Who Received Treatment With Prademagene Zamikeracel for Recessive Dystrophic Epidermolysis Bullosa (RDEB) in the Post-Marketing Setting
1,897 clinical trials
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity
Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease
A Study of Brenipatide in Adult Participants With Schizophrenia
A Study of Brenipatide in Participants With Opioid Use Disorder
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
Top Research Study Locations in Chicago
Researchers run research studies in Chicago, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Northwestern University | Metastatic Malignant Solid Neoplasm, Prostate Adenocarcinoma, Stage IV Lung Cancer AJCC v8 | 347 |
| University of Chicago | Heart Failure, Peripheral Artery Disease, Endometrial Cancer | 181 |
| Rush University Medical Center | Angelman Syndrome, Degenerative Disc Disease, Atrial Fibrillation | 155 |
| Ann & Robert H. Lurie Children's Hospital of Chicago | High Grade Glioma, Diffuse Intrinsic Pontine Glioma, WHO Grade III Glioma | 111 |
| University of Chicago Medical Center | Breast Cancer, Endometrial Cancer, Kidney Stone | 97 |
| Northwestern Memorial Hospital | Multiple Sclerosis, Heart Failure, Inguinal Hernia Bilateral | 87 |
| University of Chicago Comprehensive Cancer Center | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome | 87 |
| University of Illinois | Acute Myeloid Leukemia, Malignant Solid Neoplasm, Breast Cancer | 83 |
| University of Illinois at Chicago | Multiple Sclerosis, Carcinoma, Non-Small-Cell Lung, Chronic Stroke | 74 |
| Advocate Illinois Masonic Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 49 |
| The University of Chicago | Head and Neck Cancer, Malnutrition, AML With Gene Mutations | 41 |
| Shirley Ryan AbilityLab | Stroke, Multiple Sclerosis, Spinal Cord Injuries | 37 |
| Lurie Children's Hospital-Chicago | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 35 |
| University of Illinois Chicago | Breast Cancer Early Stage Breast Cancer (Stage 1-3), HIV Infections, Type 1 Diabetes (T1D) | 34 |
| Northwestern University Feinberg School of Medicine | Peripheral Artery Disease, Aging, Depression | 28 |
| John H Stroger Jr Hospital of Cook County | Anatomic Stage II Breast Cancer AJCC v8, Malignant Solid Neoplasm, Anatomic Stage I Breast Cancer AJCC v8 | 26 |
| Rush MD Anderson Cancer Center | Stage IVB Prostate Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 24 |
| University of Illinois Cancer Center | Breast Cancer, Gastric Cancer, Cervical Cancer | 24 |
| Rush University | Preterm, AV Block, Acute Kidney Injury | 23 |
| Northwestern Medicine | Urologic Diseases, AML - Acute Myeloid Leukemia, Amyotrophic Lateral Sclerosis | 22 |
| The University of Chicago Medical Center | Systemic Sclerosis, Acute Myeloid Leukemia, Ovarian Cancer | 21 |
| University of Chicago Medicine Comprehensive Cancer Center | Carcinoma, Squamous Cell, Prostate Cancer, Acute Leukemia | 19 |
| Lurie Children's Hospital | Congenital Heart Disease (CHD), ACL Injury, ACL Tear | 17 |
| University of Chicago Medicine | Advanced Solid Tumor, Lung Cancer, Ulcerative Colitis | 17 |
| Lurie Children's Hospital of Chicago | Acute Kidney Injury, Duchenne Muscular Dystrophy, Neurofibromatosis 1 | 13 |
Active & Upcoming Studies in Chicago (2026)
Recruiting trials in Chicago grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (603 active studies)
- BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion · Phase 1, Phase 2 · Northwestern University
- Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Phase 1 · Northwestern University
Neurology & pain (154 active studies)
- Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures · Northwestern University
- Physical Activity Intervention for Individuals Newly Diagnosed With MS · University of Illinois at Chicago
Cardiovascular (113 active studies)
- Mobile Health Management of Hypertension · University of Chicago
- PRECISION-CPR: PRecision-Controlled Ventilation in CPR · Rush University Medical Center
Diabetes & metabolic (104 active studies)
Mental health & behavior (81 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- Effects of Stimulant Medications in PTSD · Phase 1 · University of Chicago
HIV / STI (37 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Pediatric (32 active studies)
- Reducing Disparities in Knee Arthroscopy for Adolescents · Ann & Robert H Lurie Children's Hospital of Chicago
- SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease · Phase 2 · Justin Ryder
Vaccines (19 active studies)
- A Study to Characterize the Safety and Immunogenicity of AZD6489 in Participants 60 Years of Age and Older (ARIES) · Phase 1, Phase 2 · AstraZeneca
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age · Phase 3 · GlaxoSmithKline
Eye & vision (10 active studies)
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
- A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · Astellas Pharma Global Development, Inc.
Common conditions studied in Chicago
- Breast Cancer (37 active studies)
- Heart Failure (28 active studies)
- Stroke (26 active studies)
- Obesity (25 active studies)
- Acute Myeloid Leukemia (23 active studies)
- Hypertension (23 active studies)
Leading research sponsors in Chicago
- Northwestern University
- University of Chicago
- University of Illinois at Chicago
- National Cancer Institute (NCI)
- Rush University Medical Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Chicago?
There are approximately 2,157 recruiting clinical trials in Chicago, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Chicago pay participants?
Most recruiting trials in Chicago compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Chicago?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Chicago?
The most common conditions under active study in Chicago include Breast Cancer (37), Heart Failure (28), Stroke (26), Obesity (25), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Chicago?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chicago on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Chicago?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Chicago?
Recruiting research sites in Chicago include Northwestern University, University of Chicago, Rush University Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Chicago right now?
The largest active categories in Chicago are Cancer & tumors (603), Neurology & pain (154), Cardiovascular (113). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.