Neurology Clinical Trials in Chicago, IL

As of July 2026, 92 paid clinical trials are recruiting for Neurology in Chicago, Illinois. Neurology trials investigate disease-modifying therapies for Alzheimer's, Parkinson's, multiple sclerosis, ALS, and stroke recovery alongside symptomatic treatments for epilepsy, migraine, and cognitive decline. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

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97 clinical trials for Neurology

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Chicago +30 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

Apply to this trial

People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

for Multiple Sclerosis

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 70

Code: NCT07207148·Recruiting·Listed Oct 2025

Apply to this trial

Effect of Neural Constraints on Movement in Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06666673·EARLY_Phase 1·Recruiting·Listed Oct 2024

Apply to this trial

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

Sites in Chicago +29 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

Apply to this trial

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 64

Code: NCT05051618·Recruiting·Listed Sep 2021

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Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 21 - 100

Code: NCT04312269·Recruiting·Listed Mar 2020

Apply to this trial

Cortical Recording and Stimulating Array Brain-Machine Interface

for Tetraplegia

Sites in Chicago +1 more location

Sponsor: Michael Boninger

Sex: All·Age: 22 - 70

Code: NCT01894802·Recruiting·Listed Jul 2013

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Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching

for Spinal Cord Injuries

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 80

Code: NCT05424172·Recruiting·Listed Jun 2022

Apply to this trial

Nomad P-KAFO Study

for Cerebrovascular Accident

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89

Code: NCT05644522·Recruiting·Listed Dec 2022

Apply to this trial

Characterization and Clinical Trial of a Variable Friction Shoe

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT06234124·Recruiting·Listed Jan 2024

Apply to this trial

Neuromodulation and Neurorehabilitation for mTBI

for Mild Traumatic Brain Injury

Sites in Chicago +1 more location

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT03819608·Recruiting·Listed Jan 2019

Apply to this trial

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

Sites in Chicago +24 more locations

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting·Listed Jun 2023

Apply to this trial

MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)

for Stress, Psychological

Sites in Chicago, Bolingbrook & Buffalo Grove

Sponsor: University of Illinois at Chicago

Sex: All·Age: 45+

Code: NCT06002919·Recruiting·Listed Aug 2023

Apply to this trial

rTMS to Improve Cognition in Parkinson's

for Parkinson's Disease

Sites in Chicago & Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 50+

Code: NCT03836950·Phase 1, Phase 2·Recruiting·Listed Feb 2019

Apply to this trial

Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 21+

Code: NCT03401762·Recruiting·Listed Jan 2018

Apply to this trial

Combination Therapy to Improve SCI Recovery.

for Spinal Cord Injuries

Sites in Chicago +1 more location

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 70

Code: NCT05563103·Recruiting·Listed Oct 2022

Apply to this trial

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

Sites in Chicago +10 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting·Listed Dec 2024

Apply to this trial

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

for Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT04477330·Recruiting·Listed Jul 2020

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Chicago, Evanston +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

Apply to this trial

Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT05167786·Recruiting·Listed Dec 2021

Apply to this trial

Hemodynamic ABI Monitor

for Traumatic Brain Injury (TBI)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 80

Code: NCT06725108·Recruiting·Listed Dec 2024

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Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06390930·Recruiting·Listed Apr 2024

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Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk

for Menopausal

1 location in Chicago

Sponsor: University of Chicago

Sex: Female·Age: 40 - 58

Code: NCT06965686·Recruiting·Listed May 2025

Apply to this trial

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

for LVAD

Sites in Chicago +3 more locations

Sponsor: International Consortium of Circulatory Assist Clinicians

Sex: All·Age: 18 - 100

Code: NCT06039176·Recruiting·Listed Sep 2023

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Chicago +40 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Chicago +27 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

Apply to this trial

Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

for Spinal Cord Injury

Sites in Chicago & Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05157282·Recruiting·Listed Dec 2021

Apply to this trial

Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT07132775·Recruiting·Listed Aug 2025

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Impaired Interlimb Coordination During Locomotion in Individuals With Chronic Stroke: Contributors and Effect on Walking Function

for Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 25 - 90

Code: NCT07006818·Recruiting·Listed Jun 2025

Apply to this trial

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

Sites in Chicago +9 more locations

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting·Listed Nov 2021

Apply to this trial

Inpatient Stroke Recovery Using Sensors

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04219670·Recruiting·Listed Jan 2020

Apply to this trial

WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT07061691·Recruiting·Listed Jul 2025

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Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06598150·Recruiting·Listed Sep 2024

Apply to this trial

Race-Based Stress and Cognitive Training for MCI

for Mild Cognitive Impairment

1 location in Chicago

Sponsor: Rosalind Franklin University of Medicine and Science

Sex: All·Age: 65+

Code: NCT06330844·Recruiting·Listed Mar 2024

Apply to this trial

R01.Aim 2.Study 1: IsoReach

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06656754·EARLY_Phase 1·Recruiting·Listed Oct 2024

Apply to this trial

Intermittent Hypoxia in Persons With Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06276634·Recruiting·Listed Feb 2024

Apply to this trial

Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

for Tuberous Sclerosis Complex

Sites in Chicago +9 more locations

Sponsor: Darcy Krueger

Sex: All·Age: 1 Day - 6 Months

Code: NCT05104983·Phase 2·Recruiting·Listed Nov 2021

Apply to this trial

Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)

for Alzheimer Disease

1 location in Chicago

Sponsor: Alzheimer's Disease and Related Disorders Association, Inc

Sex: All·Age: 18+

Code: NCT06170268·Recruiting·Listed Dec 2023

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

Sites in Chicago, Evanston +51 more locations

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting·Listed Aug 2021

Apply to this trial

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Chicago +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

Apply to this trial

Conditions in Neurology (Chicago, IL)

Stroke· 35 Multiple sclerosis· 14 Parkinson's disease· 12 Spinal cord injury· 12 Alzheimer's disease· 10 Mild cognitive impairment (MCI)· 9 ALS (amyotrophic lateral sclerosis)· 8 Dementia· 5 Cognitive impairment / decline· 5 Myasthenia gravis· 5 Traumatic brain injury (TBI)· 5 Migraine· 4 Epilepsy· 2 Movement disorders· 2 Huntington disease· 1 Essential tremor· 1