Clinical Trials at Ann & Robert H. Lurie Children's Hospital of Chicago

As of July 2026, 101 paid clinical trials are recruiting at Ann & Robert H. Lurie Children's Hospital of Chicago, located at 225 E CHICAGO AVE # 44, CHICAGO, IL 60611, phone (312) 227-7118 in Chicago, Illinois. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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102 clinical trials at Ann & Robert H. Lurie Children's Hospital of Chicago

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Our Voices Matter: Intervention for Depression in Youth

for Depressive Symptoms

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 15 - 20·Accepts healthy volunteers

Code: NCT07216326·Recruiting·Listed Oct 2025

Apply to this trial

A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control

for Myopia

Sites in Chicago +16 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 5 - 11

Code: NCT07095894·Phase 3·Recruiting·Listed Jul 2025

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Chicago, Maywood +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

Sites in Chicago, Peoria +54 more locations

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting·Listed Nov 2025

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Chicago, Peoria +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

Sites in Chicago +18 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting·Listed Aug 2021

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Gastroschisis Outcomes of Delivery (GOOD) Study

for Gastroschisis

Sites in Chicago, Peoria +34 more locations

Sponsor: Medical College of Wisconsin

Sex: Female·Age: 18+

Code: NCT02774746·Recruiting·Listed May 2016

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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Chicago +44 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting·Listed Jan 2022

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A Prospective Database of Infants With Cholestasis

for Biliary Atresia

Sites in Chicago +8 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: Up to 6 Months

Code: NCT00061828·Recruiting·Listed Jun 2003

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Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

for Recurrent World Health Organization (WHO) Grade II Glioma

Drug: Trametinib

Sites in Chicago +14 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 1 - 25

Code: NCT04485559·Phase 1·Recruiting·Listed Jul 2020

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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

Sites in Chicago +9 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting·Listed Mar 2024

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Biliary Atresia Study in Infants and Children

for Biliary Atresia

Sites in Chicago +8 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 6 Months - 20

Code: NCT00345553·Recruiting·Listed Jun 2006

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Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

Sites in Chicago +21 more locations

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting·Listed May 2023

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VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for Solid Tumor

Drug: Atezolizumab

Sites in Chicago +6 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 6 Months - 30

Code: NCT04796012·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

for Low Grade Glioma

Sites in Chicago +2 more locations

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 1 - 26

Code: NCT06712875·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

Sites in Chicago +59 more locations

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

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Neural Prediction to Enhance Language

for Bilateral Sensorineural Hearing Loss

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 0 Months - 5

Code: NCT05962359·Recruiting·Listed Jul 2023

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TReatment for ImmUne Mediated PathopHysiology

for Acute Liver Failure

Sites in Chicago +16 more locations

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 1 - 18

Code: NCT04862221·Phase 2·Recruiting·Listed Apr 2021

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The Treatment of Type I Open Fractures in Pediatrics

for Fractures, Open

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 3 - 14

Code: NCT00870064·Recruiting·Listed Mar 2009

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Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease

for Chronic Graft Versus Host Disease

Sites in Chicago +2 more locations

Sponsor: University of Miami

Sex: All·Age: 12+

Code: NCT06663722·Phase 2·Recruiting·Listed Oct 2024

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Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

for Craniopharyngioma, Child

Sites in Chicago +14 more locations

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 1 - 39

Code: NCT05465174·Phase 2·Recruiting·Listed Jul 2022

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Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells

for Pediatric Cancer

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: All ages

Code: NCT05120518·Recruiting·Listed Nov 2021

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

Sites in Chicago +12 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting·Listed Oct 2021

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Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy

for LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\)

Sites in Chicago +13 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 5

Code: NCT06503367·Recruiting·Listed Jul 2024

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Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

Sites in Chicago +10 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting·Listed May 2023

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

Sites in Chicago +10 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting·Listed May 2023

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Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients

for Appendectomy

Sites in Chicago, Maywood & Winfield

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 3 - 18

Code: NCT06395636·Recruiting·Listed May 2024

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Retinoblastoma Patient Clinical Database and Tissue Repository

for Retinoblastoma

Sites in Chicago +7 more locations

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 0 - 18

Code: NCT04959097·Recruiting·Listed Jul 2021

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Clinical Decision Support Tool in PARDS Pilot Study

for Ventilation Therapy

Sites in Chicago +5 more locations

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 1 Month - 18

Code: NCT04068012·Recruiting·Listed Aug 2019

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Repurposing Dupilumab for Management of Pruritic Genetic Inflammatory Skin Disorders

for Skin Diseases

Drug: Dupilumab

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 6 Months+

Code: NCT05649098·EARLY_Phase 1·Recruiting·Listed Dec 2022

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The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

for Lupus Nephritis

Sites in Chicago +18 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 8 - 20

Code: NCT05538208·Phase 2·Recruiting·Listed Sep 2022

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Wearable Sensors to Detect Atypical Muscle Activation in Young Infants

for Neuromuscular Disorders

2 locations in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 0 Months - 8 Weeks

Code: NCT06970522·Recruiting·Listed May 2025

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International Rare Brain Tumor Registry

for Astroblastoma

Sites in Chicago +5 more locations

Sponsor: Children's National Research Institute

Sex: All·Age: Up to 45

Code: NCT05697874·Recruiting·Listed Jan 2023

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Chicago, Downers Grove +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Chicago, Chicago Ridge +66 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

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Dupilumab in the Treatment of Pediatric Alopecia Areata

for Alopecia Areata

Drug: Dupilumab

Sites in Chicago +4 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 6 - 17

Code: NCT05866562·Phase 2·Recruiting·Listed May 2023

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

Sites in Chicago, Downers Grove +56 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting·Listed Jul 2024

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Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease

for Sickle Cell Disease

Sites in Chicago +4 more locations

Sponsor: Robert Nickel

Sex: All·Age: 2 - 25

Code: NCT03587272·Phase 2·Recruiting·Listed Jul 2018

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Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

for Respiratory Syncytial Virus Infections

Sites in Chicago +14 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 3 Days - 2

Code: NCT05026749·Phase 3·Recruiting·Listed Aug 2021

Apply to this trial

MyPEEPS LITE Trial

for HIV/AIDS

Sites in Chicago +1 more location

Sponsor: Columbia University

Sex: Male·Age: 16 - 29·Accepts healthy volunteers

Code: NCT06741631·Recruiting·Listed Dec 2024

Apply to this trial