Paid Clinical Trials in Chicago, IL

As of June 2026, 2,238 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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2,238 clinical trials

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Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer

for Gastric Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04107077·Phase 2·Recruiting

Apply to this trial

Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)

for Community Acquired Pneumonia (CAP)

4 locations incl. Atlanta

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 12 Months - 71 Months

Code: NCT06986148·Recruiting

Apply to this trial

Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)

for Kidney Disease

3 locations incl. Victorville

Sponsor: Bodyport Inc.

Sex: All·Age: 21+

Code: NCT07059962·Recruiting

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Hypofractionation (Radiation) Trial for Multiple Myeloma

for Multiple Myeloma

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06270888·Phase 1·Recruiting

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A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

for Chronic Lymphocytic Leukemia

36 locations incl. Phoenix

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06973187·Phase 3·Recruiting

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Emotion, Aging, and Decision Making

for Motivation

1 location in Chicago

Sponsor: DePaul University

Sex: All·Age: 65 - 80·Accepts healthy volunteers

Code: NCT06071130·Not Yet Recruiting

A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT

for Schizophrenia

Drug: KarXT

8 locations incl. Los Alamitos

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 55

Code: NCT07061288·Phase 1·Recruiting

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Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

for Viral Pneumonia

22 locations incl. Sacramento

Sponsor: Synairgen Research Ltd.

Sex: All·Age: 18+

Code: NCT06999603·Phase 2·Recruiting

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Fight Fatigue: A Progressive Muscle Relaxation and Walking Intervention to Reduce Fatigue in Adults With ESKD

for End Stage Renal Disease on Dialysis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07014111·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

for Colorectal Cancer

22 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07023289·Phase 2·Recruiting

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Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

for Elevated Lp(a)

Drug: Muvalaplin

121 locations incl. Gilbert

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07157774·Phase 3·Recruiting

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Parent-Educator Action Response

for Attention Deficit and Disruptive Behavior Disorders

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: All ages

Code: NCT07203014·Enrolling By Invitation

Spinal Stimulation and Gait Training to Improve Mobility in TBI

for Traumatic Brain Injury

2 locations incl. Chicago

Sponsor: Kessler Foundation

Sex: All·Age: 18 - 65

Code: NCT06886152·Not Yet Recruiting

Pupillometry in Delayed Sleep Wake Phase Disorder

for Delayed Sleep-Wake Phase Disorder

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 16+

Code: NCT06949644·Recruiting

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Investigating Patient Satisfaction With Smart Knee Implants

for Total Knee Arthroplasty

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06968143·Recruiting

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A Study to Investigate the Effect of a Multivitamin, Multi-nutrient Supplement on Mental and Emotional Wellbeing

for Menopause

1 location in Chicago

Sponsor: Biologica Inc

Sex: Female·Age: 43 - 55·Accepts healthy volunteers

Code: NCT07146321·Not Yet Recruiting

Emotional Well-being and Measures of Healthy Aging

for Aging

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT07334106·Recruiting

Apply to this trial

PDT vs Peels for Treatment of Actinic Keratoses

for Actinic Keratoses

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04429308·Phase 2·Not Yet Recruiting

Pre-emptive Anakinra for Cytokine Event Reduction

for B-Acute Lymphoblastic Leukemia

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 1 - 25

Code: NCT06703216·Phase 1, Phase 2·Not Yet Recruiting

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

for Neurofibromatosis 1

Drug: Selumetinib

15 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 1 - 8

Code: NCT06188741·Phase 2·Recruiting

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Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection

for Liver Transplant Surgery

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06698146·Recruiting

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A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

for Metastatic Gastric Adenocarcinoma

19 locations incl. Chandler

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT07043400·Phase 3·Recruiting

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A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia

for Cognitive Impairment Associated With Schizophrenia (CIAS)

13 locations incl. Little Rock

Sponsor: Kynexis B.V.

Sex: All·Age: 18 - 55

Code: NCT07191483·Phase 2·Recruiting

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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

for Advanced Pancreatic Carcinoma

109 locations incl. Birmingham

Sponsor: Sameek Roychowdhury

Sex: All·Age: 18+

Code: NCT06906562·Phase 2·Recruiting

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

for Invasive Mold Infections

18 locations incl. Birmingham

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT06925321·Phase 3·Recruiting

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Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

for PIK3CA Mutation

51 locations incl. Gilbert

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06982521·Phase 3·Recruiting

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Web-Based Toolkit to Improve Cancer-Related Emotional Distress and Anxiety in Rural Older Cancer Survivors

for Hematopoietic and Lymphatic System Neoplasm

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07290543·Recruiting

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DRonabinol Treatment of OSA

for Obstructive Sleep Apnea

1 location in Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: Up to 65

Code: NCT06477952·Phase 1, Phase 2·Recruiting

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An International Observational Study of Adults With Acute Infection

for Infectious Disease

19 locations incl. Tucson

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting

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Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

for Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

279 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06958328·Phase 3·Recruiting

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Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).

for Orofacial Myofunctional Disorders

2 locations incl. Chicago

Sponsor: Myo Munchee (Operations) Pty Ltd

Sex: All·Age: 3 - 5·Accepts healthy volunteers

Code: NCT07088055·Recruiting

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Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

for Gastric Adenocarcinoma

55 locations incl. Irvine

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT07001748·Phase 2, Phase 3·Recruiting

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Point of Care Lung Ultrasound Examination in Patients With Shortness of Breath

for Lung Disease

3 locations incl. New Haven

Sponsor: GE Healthcare

Sex: All·Age: 22+

Code: NCT07046234·Enrolling By Invitation

The Impact of a Podcast-based Body Image Intervention Among Millennial Women

for Body Image

1 location in Chicago

Sponsor: University of the West of England

Sex: Female·Age: 29 - 44·Accepts healthy volunteers

Code: NCT07113678·Recruiting

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Transcutaneous Electrical Stimulation for Stroke Patients

for Upper Limb Hemiparesis Following Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT06950593·Recruiting

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A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

for Small-cell Lung Cancer

Drug: Durvalumab

44 locations incl. Casa Grande

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07005128·Phase 3·Recruiting

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COPD Resources, Education, and Activity Designed for You Study

for COPD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40+

Code: NCT07125053·Recruiting

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Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for Acute Myeloid Leukemia

22 locations incl. New Haven

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06484062·Phase 1·Recruiting

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Cemiplimab for the Treatment of Incurable Metastatic or Unresectable NUT Carcinoma

for Metastatic NUT Carcinoma

Drug: Cemiplimab

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07050186·Phase 2·Recruiting

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

8 locations incl. Sacramento

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting

Apply to this trial