Paid Clinical Trials in Chicago, IL

As of June 2026, 2,238 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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2,238 clinical trials

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Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

for Opiod Use Disorder

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07498322·Not Yet Recruiting

A Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma

for Severe Asthma

Drug: Frevecitinib

15 locations incl. Lancaster

Sponsor: Kinaset Therapeutics Inc

Sex: All·Age: 18 - 75

Code: NCT07532265·Phase 2·Not Yet Recruiting

Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males

for Inguinal Hernia Unilateral

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 50+

Code: NCT07604272·Phase 1·Not Yet Recruiting

Food and Metabolism Study

for Prediabetes

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT07624500·Not Yet Recruiting

Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

for Nicotine Use Disorder

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26

Code: NCT06837220·Recruiting

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Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

for Posttraumatic Osteoarthritis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 50

Code: NCT07142369·Not Yet Recruiting

The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults

for Kidney Stones

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07389226·Not Yet Recruiting

Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty?

for Vaginoplasty

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT07412509·Not Yet Recruiting

Outpatient Visits Versus Telehealth for Postoperative Care After Minimally Invasive Gynecologic Surgery

for to Determine Whether Patient Satisfaction With Postoperative Telehealth Follow-up is Non-inferior to In-person Clinic Visits

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: Female·Age: 18+

Code: NCT07420114·Not Yet Recruiting

The FLOW Registry.

for Benign Prostatic Hyperplasia (BPH)

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT07430423·Not Yet Recruiting

Genicular Artery Embolization for Knee Osteoarthritis

for Osteoarthritis

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT07537153·Recruiting

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GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer

for Gastric Adenocarcinoma

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07581405·Phase 2·Not Yet Recruiting

Defining the Ablative Dose for Y-90 TARE

for HCC - Hepatocellular Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07586046·Phase 2·Not Yet Recruiting

BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder

for Early-stage Breast Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18+

Code: NCT07596212·Phase 1, Phase 2·Not Yet Recruiting

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

for Alzheimer Disease

Drug: Donanemab

52 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 55+

Code: NCT07602582·Phase 3·Not Yet Recruiting

Multi-Site Trial of Tirzepatide for Smoking Cessation

for Smoking Cessation

Drug: Tirzepatide

4 locations incl. Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 21 - 65

Code: NCT07602699·Phase 2·Recruiting

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Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome

for Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07469176·Not Yet Recruiting

Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting

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Resilience-Building for Advance Care Planning

for Advanced Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 80

Code: NCT07428278·Recruiting

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tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy

for Cerebral Palsy

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 4 - 17

Code: NCT07433023·Phase 2·Recruiting

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Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy

for Cerebral Palsy

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 8 - 17

Code: NCT07434492·Phase 2·Recruiting

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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

for Obesity

Drug: Semaglutide

99 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07564414·Phase 3·Recruiting

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Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

for Type 2 Diabetes

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 18 - 65

Code: NCT07650682·Recruiting

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Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

for Major Depressive Disorder

25 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06705478·Phase 2·Recruiting

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AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

for Hernia

12 locations incl. Loma Linda

Sponsor: Tissium

Sex: All·Age: 22+

Code: NCT07277946·Recruiting

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Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma

Drug: PF-08634404

61 locations incl. Los Angeles

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07392892·Phase 2, Phase 3·Recruiting

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Early Signals of the Transition From Immune Quiescence to Activation in the Liver Allograft Microenvironment and in the Circulation

for Liver Transplant

10 locations incl. San Francisco

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 13

Code: NCT07549503·Phase 2·Recruiting

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Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

for Type 2 Diabetes Mellitus

12 locations incl. Los Angeles

Sponsor: Insulet Corporation

Sex: All·Age: 14 - 75

Code: NCT07579702·Recruiting

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An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

for Cardiovascular Disease and Lipoprotein(a)

Drug: Pelacarsen

115 locations incl. Andalusia

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07517263·Phase 3·Recruiting

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Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

for Overweight (BMI > 25)

2 locations incl. Chicago

Sponsor: Midwest Center for Metabolic and Cardiovascular Research

Sex: All·Age: 21 - 74·Accepts healthy volunteers

Code: NCT07566325·Not Yet Recruiting

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

for Obesity

Drug: NNC0487-0111

202 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07567001·Phase 3·Not Yet Recruiting

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

for Major Depressive Disorder

27 locations incl. Gilbert

Sponsor: Definium Therapeutics US, Inc.

Sex: All·Age: 18 - 74

Code: NCT07592689·Phase 3·Recruiting

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Dasatinib for HIV-1 Reservoir Reduction

for HIV Infections

3 locations incl. Chicago

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT07342491·Phase 1·Recruiting

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A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

for Solid Tumors

Drug: Adagrasib

17 locations incl. Phoenix

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07415031·Phase 2·Recruiting

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Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial

for Myopia

14 locations incl. Birmingham

Sponsor: Ohio State University

Sex: All·Age: 6 - 11·Accepts healthy volunteers

Code: NCT07567040·Phase 3·Recruiting

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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

17 locations incl. San Diego

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571005·Phase 3·Recruiting

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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

20 locations incl. Gilbert

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571109·Phase 3·Recruiting

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Automatically Transmitted Home Blood Pressure and Automated Patient Feedback in Hypertension Care: the AUTO 2 Trial

for Hypertension (HTN)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 84

Code: NCT07397260·Enrolling By Invitation

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

for Colitis, Ulcerative

15 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483073·Phase 2·Recruiting

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A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

for Crohn Disease

Drug: LY4395089

15 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483099·Phase 2·Recruiting

Apply to this trial