Clinical Trials at Case Western Reserve University

As of July 2026, 81 paid clinical trials are recruiting at Case Western Reserve University, located at 10701 EAST BLVD, K-216, CLEVELAND, OH 44106-1702, phone (216) 791-3800 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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81 clinical trials at Case Western Reserve University

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Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

227 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting

Apply to this trial

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

for Grade 2 Meningioma

198 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT03180268·Phase 3·Recruiting

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Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

for Endometrial Adenocarcinoma

Drug: Ipilimumab

137 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05112601·Phase 2·Recruiting

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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

117 locations incl. Goodyear

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

19 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting

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Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

54 locations incl. Birmingham

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting

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PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

for Type III Achalasia

13 locations incl. Scottsdale

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293689·Recruiting

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PREcision MEDicine In Achalasia (PREMEDIA)

for Type I Achalasia

13 locations incl. Scottsdale

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293650·Phase 3·Recruiting

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Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

for Clinical Stage I Esophageal Adenocarcinoma AJCC v8

96 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT03801876·Phase 3·Recruiting

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Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

for Endometrial Cancer

72 locations incl. Anchorage

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 18+

Code: NCT05640999·Phase 2·Recruiting

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Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors

for Advanced Lung Neuroendocrine Tumor

29 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04665739·Phase 2·Recruiting

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting

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Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

43 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06287775·Phase 1, Phase 2·Recruiting

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Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

for Obstetrical Complications

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06605118·Phase 3·Recruiting

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Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

for Lung Adenocarcinoma

34 locations incl. Buena Park

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05198830·Phase 2·Recruiting

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Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

for Preterm Delivery

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: 14+·Accepts healthy volunteers

Code: NCT06980025·Phase 3·Recruiting

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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

for Metastatic Colorectal Carcinoma

60 locations incl. Birmingham

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT05863195·Phase 3·Recruiting

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Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy

for Recurrent Mantle Cell Lymphoma

Drug: Glofitamab

9 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07003295·Phase 2·Recruiting

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Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

for Locally Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

9 locations incl. Sacramento

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07012031·Phase 1, Phase 2·Recruiting

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Parent-Mediated Telehealth Intervention for Insomnia in Young Autistic Children

for Insomnia

3 locations incl. Atlanta

Sponsor: Emory University

Sex: All·Age: 3 - 7

Code: NCT07435740·Recruiting

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Humidity Asthma Interventions for Low Socioeconomic Status Children

for Pediatric Asthma

2 locations incl. Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: Up to 18

Code: NCT07453667·Recruiting

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Youth Empowerment and Safety Intervention

for Suicide

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 12 - 17

Code: NCT07214233·Recruiting

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Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

for Periodontitis, Diabetes Mellitus Type 2

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 18+

Code: NCT07298057·EARLY_Phase 1·Recruiting

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Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia

for Spinal Cord Injury Cervical

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 22 - 65

Code: NCT07225582·Recruiting

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Preventing Athlete Under-fueling Through Nutrition.

for Athlete

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07136038·Recruiting

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Positive Processes and Transition to Health - Single-Session (PATH-SS)

for PTSD

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 18 - 65

Code: NCT06900712·Recruiting

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LT Comparative Effectiveness of 2 Caries Treatments

for Dental Caries

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 62+·Accepts healthy volunteers

Code: NCT07213661·Recruiting

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

11 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting

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Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Drug: Polatuzumab Vedotin

8 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06015880·Phase 1·Recruiting

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Developing Resilience and Anxiety Management Through the Arts

for Anxiety

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 8 - 17

Code: NCT07033052·Recruiting

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Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

for Recurrent Endometrial Carcinoma

14 locations incl. Augusta

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05950464·Phase 1·Recruiting

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A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

2 locations incl. Cleveland

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05834244·Phase 1·Recruiting

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Oral Health Intervention in Adult Primary Care

for Dental Caries

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06555029·Recruiting

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Obeticholic Acid for Prevention in Barrett's Esophagus

for Barrett Esophagus

8 locations incl. Kansas City

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04939051·Phase 2·Recruiting

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OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)

for Hypertension

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 50+

Code: NCT05293756·Recruiting

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Impact of 4PCP on Practitioner and Patient Outcomes

for Chronic Pain

4 locations incl. Cleveland

Sponsor: Virginia Commonwealth University

Sex: All·Age: 14 - 80

Code: NCT05580419·Recruiting

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Peripheral Interfaces in Amputees for Sensorimotor Integration

for Upper Extremity Amputee

2 locations incl. Cleveland

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT04430218·Recruiting

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Positive Processes and Transition to Health (PATH)

for Posttraumatic Stress Disorder

3 locations incl. Newark

Sponsor: Case Western Reserve University

Sex: All·Age: 18 - 65

Code: NCT06093906·Recruiting

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Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

6 locations incl. Kansas City

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2·Recruiting

Apply to this trial