Clinical Trials at Cleveland Clinic

As of August 2026, 320 paid clinical trials are recruiting at Cleveland Clinic, located at 9500 EUCLID AVE # C21, CLEVELAND, OH 44195-0001, phone (216) 444-0522 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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322 clinical trials at Cleveland Clinic

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A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

for Macular Edema

Sites in Cleveland +32 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06962839·Phase 2·Recruiting·Listed May 2025

Apply to this trial

A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

for Neutropenia

Sites in Cleveland, Cincinnati +19 more locations

Sponsor: X4 Pharmaceuticals

Sex: All·Age: 12+

Code: NCT06056297·Phase 3·Recruiting·Listed Sep 2023

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AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

for Mesial Temporal Lobe Epilepsy

Sites in Cleveland, Columbus +14 more locations

Sponsor: UniQure Biopharma B.V.

Sex: All·Age: 18 - 75

Code: NCT06063850·Phase 1, Phase 2·Recruiting·Listed Oct 2023

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GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

Sites in Cleveland, Columbus +20 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting·Listed Feb 2025

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

Sites in Cleveland +19 more locations

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025

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A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

Sites in Cleveland, Columbus +21 more locations

Sponsor: LEO Pharma

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting·Listed Oct 2024

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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

Sites in Cleveland +16 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting·Listed Sep 2024

Apply to this trial

CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

Sites in Cleveland +20 more locations

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting·Listed Nov 2024

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A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

Sites in Cleveland +23 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06722235·Phase 3·Recruiting·Listed Dec 2024

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A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for HR+ Breast Cancer

Sites in Cleveland +17 more locations

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07029399·Phase 1·Recruiting·Listed Jun 2025

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

Sites in Cleveland, Columbus +18 more locations

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting·Listed Dec 2022

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Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML

for AML, Adult

Sites in Cleveland, Columbus +9 more locations

Sponsor: Stelexis BioSciences

Sex: All·Age: 18+

Code: NCT06533761·Phase 1·Recruiting·Listed Aug 2024

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A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

Sites in Cleveland, Columbus +12 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting·Listed Jun 2025

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A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

for Lung Cancer

Sites in Cleveland, Columbus +11 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06618287·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

Sites in Cleveland +13 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06385080·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sites in Cleveland, Columbus +16 more locations

Sponsor: Arga Medtech SA

Sex: All·Age: 18 - 80

Code: NCT06784466·Recruiting·Listed Jan 2025

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A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

for Nasopharyngeal Cancer Recurrent

Sites in Cleveland, Cincinnati +9 more locations

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 12+

Code: NCT06457503·Phase 4·Recruiting·Listed Jun 2024

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A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

for Advanced Solid Tumor

Drug: NXP900

Sites in Cleveland +12 more locations

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05873686·Phase 1·Recruiting·Listed May 2023

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First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Cleveland, Columbus +11 more locations

Sponsor: Tubulis GmbH

Sex: All·Age: 18+

Code: NCT06657222·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

for Autosomal Recessive Polycystic Kidney (ARPKD)

Sites in Cleveland, Cincinnati +4 more locations

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 28 Days - 18

Code: NCT04782258·Phase 3·Recruiting·Listed Mar 2021

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Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

for Myelofibrosis

Sites in Cleveland, Columbus +22 more locations

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT05320198·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

for Ulcerative Colitis

Sites in Cleveland +13 more locations

Sponsor: Takeda

Sex: All·Age: 2 - 17

Code: NCT06405087·Phase 3·Recruiting·Listed May 2024

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Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)

for Low Risk Myelodysplastic Syndromes

Sites in Cleveland, Columbus +11 more locations

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05308264·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

for Chronic Lymphocytic Leukemia (CLL)

Sites in Cleveland, Cincinnati +13 more locations

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05131022·Phase 1·Recruiting·Listed Nov 2021

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A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)

for Respiratory Distress Syndrome, Acute

Sites in Cleveland +4 more locations

Sponsor: GEn1E Lifesciences

Sex: All·Age: 18 - 85

Code: NCT05795465·Phase 2·Recruiting·Listed Apr 2023

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Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

for Familial Adenomatous Polyposis (FAP)

Sites in Cleveland, Columbus +16 more locations

Sponsor: Rapamycin Holdings Inc.

Sex: All·Age: 18+

Code: NCT06950385·Phase 3·Recruiting·Listed Apr 2025

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Pilot/Pivotal Study of DBS+Rehab After Stroke

for Stroke

Sites in Cleveland +8 more locations

Sponsor: Enspire DBS Therapy, Inc.

Sex: All·Age: 21+

Code: NCT05701280·Recruiting·Listed Jan 2023

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Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Cleveland +21 more locations

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06343402·Phase 1·Recruiting·Listed Apr 2024

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Acellular Dermal Matrix Investigation in Breast Reconstruction

for Breast Reconstruction

Sites in Cleveland +12 more locations

Sponsor: RTI Surgical

Sex: Female·Age: 22+·Accepts healthy volunteers

Code: NCT06456554·Recruiting·Listed Jun 2024

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A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

for Focal Onset Seizures

Sites in Cleveland, Columbus +15 more locations

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05716100·Phase 3·Recruiting·Listed Feb 2023

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Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

for HR+/HER2-negative Breast Cancer

Sites in Cleveland +9 more locations

Sponsor: SynDevRx, Inc.

Sex: All·Age: 18+

Code: NCT05455619·Phase 1, Phase 2·Recruiting·Listed Jul 2022

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Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms With Surpass Elite With GUARDian Flow Diverter (GUARD)

for Aneurysm

Sites in Cleveland +9 more locations

Sponsor: Stryker Neurovascular

Sex: All·Age: 18 - 80

Code: NCT06872684·Recruiting·Listed Mar 2025

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A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: Ruxolitinib

Sites in Cleveland +12 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06034002·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for Solid Tumor Malignancies

Sites in Cleveland +14 more locations

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT06994806·Phase 1·Recruiting·Listed May 2025

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A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)

for New Onset Generalized Myasthenia Gravis (gMG)

Drug: Efgartigimod PH20 SC

Sites in Cleveland +17 more locations

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06909214·Phase 4·Recruiting·Listed Apr 2025

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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for Solid Tumor Malignancies

Sites in Cleveland, Maumee +11 more locations

Sponsor: Tasca Therapeutics

Sex: All·Age: 18+

Code: NCT07030257·Phase 1, Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

Sites in Cleveland +17 more locations

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting·Listed Jul 2020

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

Sites in Cleveland +18 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting·Listed Oct 2021

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A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

for Renal Cell Carcinoma

Sites in Cleveland +19 more locations

Sponsor: HiberCell, Inc.

Sex: All·Age: 18+

Code: NCT06234605·Phase 1·Recruiting·Listed Jan 2024

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Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

for Hypertrophic Cardiomyopathy

Sites in Cleveland +4 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 75

Code: NCT05836259·Phase 1, Phase 2·Recruiting·Listed May 2023

Apply to this trial