Clinical Trials at Cleveland Clinic

As of July 2026, 345 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 13, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

345 clinical trials at Cleveland Clinic

·Clear filters·↓ Download CSV

CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

42 locations incl. Birmingham

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting

Apply to this trial

Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

Apply to this trial

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

22 locations incl. South Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting

Apply to this trial

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

Apply to this trial

Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

for Stage III Ovarian Cancer

Drug: Niraparib

59 locations incl. Duarte

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05659381·Phase 3·Recruiting

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

54 locations incl. Birmingham

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting

Apply to this trial

Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting

Apply to this trial

HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial

for Hip Fractures

19 locations incl. Chandler

Sponsor: Population Health Research Institute

Sex: All·Age: 45+

Code: NCT04743765·Recruiting

Apply to this trial

Longitudinal Study of the Porphyrias

for Acute Porphyrias

16 locations incl. Birmingham

Sponsor: The American Porphyrias Expert Collaborative

Sex: All·Age: 1 Minute+

Code: NCT01561157·Recruiting

Apply to this trial

Nephrotic Syndrome Study Network

for Minimal Change Disease (MCD)

39 locations incl. Los Angeles

Sponsor: University of Michigan

Sex: All·Age: Up to 80

Code: NCT01209000·Recruiting

Apply to this trial

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

42 locations incl. Birmingham

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting

Apply to this trial

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

for Giant Cell Tumor of Bone

14 locations incl. Los Angeles

Sponsor: St. Louis University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03295981·Phase 3·Recruiting

Apply to this trial

Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

34 locations incl. Birmingham

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting

Apply to this trial

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

for Mitochondrial Disorders

16 locations incl. San Diego

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01694940·Recruiting

Apply to this trial

JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

16 locations incl. Redwood City

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting

Apply to this trial

A Randomized Multicenter Study for Isolated Skin Vasculitis

for Primary Cutaneous Vasculitis

12 locations incl. Kansas City

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02939573·Phase 2·Recruiting

Apply to this trial

Multi-Center Clean Air Randomized Controlled Trial in COPD

for Chronic Obstructive Pulmonary Disease (COPD)

11 locations incl. Birmingham

Sponsor: JHSPH Center for Clinical Trials

Sex: All·Age: 40+

Code: NCT06376994·Phase 3·Recruiting

Apply to this trial

Preoperative Fasting vs. Not Fasting in Critically Ill Patients

for Critical Illness

19 locations incl. Palo Alto

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06751043·Recruiting

Apply to this trial

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

12 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting

Apply to this trial

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

for Acute Myocardial Infarction

13 locations incl. Los Angeles

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT05701358·Recruiting

Apply to this trial

Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

for Osteonecrosis of the Femoral Head

10 locations incl. Los Angeles

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT06123481·Recruiting

Apply to this trial

StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

41 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting

Apply to this trial

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

for Endometrial Cancer

24 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05051722·Recruiting

Apply to this trial

Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

for Cryoglobulinemic Vasculitis (CV)

8 locations incl. Los Angeles

Sponsor: Peter Merkel

Sex: All·Age: 5+

Code: NCT03004326·Recruiting

Apply to this trial

Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

26 locations incl. Tucson

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting

Apply to this trial

Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

for Alcohol-associated Hepatitis

6 locations incl. Indianapolis

Sponsor: Samer Gawrieh

Sex: All·Age: 18 - 70

Code: NCT07060638·Phase 2·Recruiting

Apply to this trial

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

for Liver Diseases

18 locations incl. Los Angeles

Sponsor: European Foundation for Study of Chronic Liver Failure

Sex: All·Age: 18 - 80

Code: NCT04613921·Recruiting

Apply to this trial

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

30 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting

Apply to this trial

HCMR Re-Imaging Study

for Hypertrophic Cardiomyopathy (HCM)

6 locations incl. Evanston

Sponsor: Christopher Kramer

Sex: All·Age: 18 - 65

Code: NCT07054073·Recruiting

Apply to this trial

Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response

for Primary Central Nervous System Lymphoma

7 locations incl. New York

Sponsor: Providence Health & Services

Sex: All·Age: 18+

Code: NCT06175000·Phase 2·Recruiting

Apply to this trial

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

for Pulmonary Invasive Fungal Infections

32 locations incl. Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days - 21

Code: NCT03827694·Recruiting

Apply to this trial

HOPE Against Cancer Recurrence in HCC

for Liver Transplantation

2 locations incl. New York

Sponsor: Philipp Dutkowski

Sex: All·Age: 18+

Code: NCT06717919·Phase 4·Recruiting

Apply to this trial

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for Non-small Cell Lung Cancer

20 locations incl. Gilbert

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT05786924·Phase 1, Phase 2·Recruiting

Apply to this trial

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

for Relapsed or Refractory Acute Myeloid Leukemia (AML)

26 locations incl. Birmingham

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT02074839·Phase 1·Recruiting

Apply to this trial

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

for Non-Small Cell Lung Cancer

40 locations incl. La Jolla

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT02468024·Phase 3·Recruiting

Apply to this trial

Wearable Technology in Heart Failure Patients

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT07650669·Recruiting·Listed Jun 16, 2026

Apply to this trial

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

13 locations incl. Miami

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting

Apply to this trial

Kidney Precision Medicine Project

for Acute Kidney Failure

13 locations incl. Tucson

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04334707·Recruiting

Apply to this trial

One-Time DNA Study for Vasculitis

for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

11 locations incl. Los Angeles

Sponsor: University of Pennsylvania

Sex: All·Age: 7+

Code: NCT01241305·Recruiting

Apply to this trial