Paid Clinical Trials in Cleveland, OH

As of September 2026, 1,261 paid clinical trials are recruiting in Cleveland, Ohio. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 17, 2026.

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1,129 clinical trials

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Cleveland, Akron +162 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

Apply to this trial

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

for Relapsing Multiple Sclerosis

Sites in Cleveland, Cincinnati +18 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT04047628·Phase 3·Recruiting·Listed Aug 2019

Apply to this trial

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for Non-small Cell Lung Cancer

Sites in Cleveland +20 more locations

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT05786924·Phase 1, Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment

for Tricuspid Regurgitation

Sites in Cleveland, Cincinnati +7 more locations

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06033274·Recruiting·Listed Sep 2023

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Multi-Center Clean Air Randomized Controlled Trial in COPD

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Cleveland +10 more locations

Sponsor: JHSPH Center for Clinical Trials

Sex: All·Age: 40+

Code: NCT06376994·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC

for Postoperative Complications

1 location in Cleveland

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 21 - 79

Code: NCT06864819·Recruiting·Listed Mar 2025

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Cleveland, Akron +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

Apply to this trial

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Cleveland +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

Apply to this trial

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

for Atrial Fibrillation

Sites in Cleveland +1 more location

Sponsor: The Cleveland Clinic

Sex: All·Age: 22+

Code: NCT07122947·Recruiting·Listed Aug 2025

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Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

Sites in Cleveland, Columbus +31 more locations

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting·Listed Jun 2023

Apply to this trial

Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Cleveland, Akron +64 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

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Community Benefit of No-charge Calcium Score Screening Program

for Cardiovascular Risk Factor

1 location in Cleveland

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 18 - 100

Code: NCT04075162·Recruiting·Listed Aug 2019

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Investigation of Impact of AI on Prostate Cancer Workflow

for Prostate Cancer

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 55 - 80

Code: NCT07084779·Recruiting·Listed Jul 2025

Apply to this trial

Fatty Acid Binding Proteins and Markers of Cellular Senescence in Cancer Survivors

for Marker

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 5 - 50

Code: NCT07114614·Recruiting·Listed Aug 2025

Apply to this trial

Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis

for Parkinson's Disease Psychosis

Sites in Cleveland +8 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT04373317·Phase 4·Recruiting·Listed May 2020

Apply to this trial

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Cleveland, Columbus +31 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

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Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

for Colorectal Cancer

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07044362·Recruiting·Listed Jun 2025

Apply to this trial

RA-PRO PRAGMATIC TRIAL

for Rheumatoid Arthritis

Sites in Cleveland, Liberty Township +46 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT04692493·Phase 3·Recruiting·Listed Dec 2020

Apply to this trial

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

Sites in Cleveland, Columbus +11 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting·Listed Mar 2025

Apply to this trial

Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients

for Lung Transplant

Sites in Cleveland, Cincinnati +9 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12+

Code: NCT06476132·Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

An International Observational Study of Adults With Acute Infection

for Infectious Disease

Sites in Cleveland +19 more locations

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting·Listed Jul 2025

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Cleveland, Akron +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

Apply to this trial

Musculoskeletal Cancers Remote Monitoring and Care

for Osteosarcoma

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07129226·Recruiting·Listed Aug 2025

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Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

for Locally Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

Sites in Cleveland, Columbus +7 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07012031·Phase 1, Phase 2·Recruiting·Listed Jun 2025

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Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy

for Recurrent Mantle Cell Lymphoma

Drug: Glofitamab

Sites in Cleveland, Columbus +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07003295·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood

for aGVHD

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06904482·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Cleveland, Parma +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

Apply to this trial

Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction

for Oral Cancer

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07110142·Recruiting·Listed Aug 2025

Apply to this trial

Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery

for Neoadjuvant Treatment

Sites in Cleveland +3 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06959511·Phase 2·Recruiting·Listed May 2025

Apply to this trial

I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value

for Stroke

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT06585943·Recruiting·Listed Sep 2024

Apply to this trial

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

for Non-muscle-invasive Bladder Cancer

Sites in Cleveland +7 more locations

Sponsor: White River Junction Veterans Affairs Medical Center

Sex: All·Age: 18+

Code: NCT05796375·Phase 2·Recruiting·Listed Apr 2023

Apply to this trial

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for Barrett Esophagus

Sites in Cleveland +4 more locations

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06687603·Recruiting·Listed Nov 2024

Apply to this trial

Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer

for Breast Cancer

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: Female·Age: 18 - 65

Code: NCT04362826·Recruiting·Listed Apr 2020

Apply to this trial

Unintentional Weight Loss and Cancer: A Prospective Trial of Patient-centered Weight Tracking Combined With GRAIL Galleri Testing to Improve Early Detection

for Unintended Weight Loss

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 40 - 80

Code: NCT05481697·Recruiting·Listed Aug 2022

Apply to this trial

Patient Navigator PRE-ACT Educational Intervention to Promote Decision Making Among Minorities

for Educational Intervention

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05701085·Recruiting·Listed Jan 2023

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Is Intraperitoneal Drainage Necessary Following Distal Pancreatectomy?

for Cyst of Pancreas

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05720338·Phase 3·Recruiting·Listed Feb 2023

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Immediate Versus Delayed Loading of Maxillary Overdenture Implants

for Implant Complication

Sites in Cleveland +1 more location

Sponsor: Case Western Reserve University

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06038487·Recruiting·Listed Sep 2023

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Development of MRF for Characterization of Brain Tumors After Radiotherapy

for Brain Tumor

2 locations in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06101069·Recruiting·Listed Oct 2023

Apply to this trial

MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)

for Prostate Cancer

Sites in Cleveland +2 more locations

Sponsor: Case Comprehensive Cancer Center

Sex: Male·Age: 18+

Code: NCT06150417·Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

for Gastrointestinal Cancer

1 location in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06263088·Recruiting·Listed Feb 2024

Apply to this trial