Paid Clinical Trials in Columbia, SC

As of September 2026, 155 paid clinical trials are recruiting in Columbia, South Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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141 clinical trials

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

Sites in Columbia, Charleston +170 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting·Listed Mar 2020

Apply to this trial

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Columbia +44 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting·Listed Jan 2022

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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

Sites in Columbia, Greenville +93 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting·Listed Apr 2024

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in Columbia, Charleston +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Columbia, Charleston +200 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Phentermine's Impact on Treatment in Teens

for Childhood Obesity

Sites in Columbia +5 more locations

Sponsor: Russell McCulloh, MD

Sex: All·Age: 12 - 17

Code: NCT07282340·Phase 2·Recruiting·Listed Dec 2025

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Columbia, Charleston +141 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy

for Open tíbia Fracture

Sites in Columbia, Greenville +24 more locations

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT05615844·Phase 3·Recruiting·Listed Nov 2022

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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

Sites in Columbia, Greenville +70 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting·Listed Jan 2023

Apply to this trial

Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

for Stroke

Sites in Columbia, Charleston +38 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05338697·Recruiting·Listed Apr 2022

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in Columbia, Greenville +100 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

Apply to this trial

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Columbia, Charleston +162 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

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Systemic Hypothermia in Acute Cervical Spinal Cord Injury

for Spinal Cord Injury, Acute

Sites in Columbia +4 more locations

Sponsor: University of Miami

Sex: All·Age: 18 - 70

Code: NCT02991690·Recruiting·Listed Dec 2016

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Cord Clamping Among Neonates With Congenital Heart Disease

for Congenital Heart Disease (CHD)

Sites in Columbia +17 more locations

Sponsor: Carl Backes, MD

Sex: All·Age: 37 Weeks - 42 Weeks

Code: NCT06153459·Recruiting·Listed Dec 2023

Apply to this trial

Improving the Collaborative Health of Adult Dyads

for Cardiovascular Diseases

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05370014·Recruiting·Listed May 2022

Apply to this trial

Escitalopram and Language Intervention for Subacute Aphasia

for Aphasia

Sites in Columbia, Charleston +1 more location

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 99

Code: NCT03843463·Phase 2·Recruiting·Listed Feb 2019

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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

for Stroke

Sites in Columbia +27 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05907629·Recruiting·Listed Jun 2023

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Neural Bases of Vocal Sensorimotor Impairment in Aphasia

for Aphasia

Sites in Columbia +2 more locations

Sponsor: The University of Texas at Dallas

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT04742894·Recruiting·Listed Feb 2021

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Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

for Carcinoma, Hepatocellular

Sites in Columbia, Charleston +31 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75

Code: NCT05486572·Recruiting·Listed Aug 2022

Apply to this trial

Precision Rehabilitation for Veterans With (HFpEF)

for Heart Failure

1 location in Columbia

Sponsor: Columbia VA Health Care System

Sex: All·Age: 18+

Code: NCT07493915·Recruiting·Listed Mar 2026

Apply to this trial

Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

for Mild-moderate Cognitive Impairment

Sites in Columbia & Sumter

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06799429·Recruiting·Listed Jan 2025

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Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement

for Knee Replacement

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06768762·Recruiting·Listed Jan 2025

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Columbia, Mt. Pleasant +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Columbia +67 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

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Dose Response of Exercise for Arthritis Management

for Arthritis

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06880653·Recruiting·Listed Mar 2025

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Telerehabilitation for Aphasia (TERRA)

for Aphasia

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 21 - 80

Code: NCT04682223·Recruiting·Listed Dec 2020

Apply to this trial

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

Sites in Columbia, Charleston +66 more locations

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

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Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations

for Chronic Pain (Back / Neck)

Sites in Columbia +2 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18 - 85

Code: NCT07179016·Recruiting·Listed Sep 2025

Apply to this trial

PUSH-IT Continuing Enteral Feeds for Tracheostomy

for Tracheostomy Complication

Sites in Columbia +5 more locations

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT05906472·Recruiting·Listed Jun 2023

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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

for Prediabetic State

Sites in Columbia, Charleston +36 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT02915198·Phase 4·Recruiting·Listed Sep 2016

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Reducing Metabolic Dysregulation in Dyads

for Colorectal Cancer

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 9 - 55·Accepts healthy volunteers

Code: NCT06117241·Recruiting·Listed Nov 2023

Apply to this trial

Optimal Digital Weight Loss Treatment for Rural Individuals

for Overweight and Obesity

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06105957·Recruiting·Listed Oct 2023

Apply to this trial

Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems

for Clavicle

Sites in Columbia +2 more locations

Sponsor: AO Innovation Translation Center

Sex: All·Age: 18+

Code: NCT04921865·Recruiting·Listed Jun 2021

Apply to this trial

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

Sites in Columbia +51 more locations

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting·Listed Apr 2012

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Mobile Supportive Teams for Reinforcing Increased Daily Exercise Study

for Physical Activity

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06662292·Recruiting·Listed Oct 2024

Apply to this trial

Pistachio Snacking and Metabolic Flexibility

for Overweight (BMI &gt

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 25 - 45·Accepts healthy volunteers

Code: NCT07340125·Recruiting·Listed Jan 2026

Apply to this trial

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

for Heart Failure

Sites in Columbia +11 more locations

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 100

Code: NCT06425848·Recruiting·Listed May 2024

Apply to this trial

Increasing Affordable Fruits and Vegetables for Families With Food Insecurity

for Diet

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 2 - 10·Accepts healthy volunteers

Code: NCT06828445·Phase 1·Recruiting·Listed Feb 2025

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Implementation Supports for Improving Identification and Delivery of School-based Mental Health Supports for Middle Schools Students

for Mental Health Issue

Sites in Columbia +2 more locations

Sponsor: University of Virginia

Sex: All·Age: 10 - 99·Accepts healthy volunteers

Code: NCT06047041·Recruiting·Listed Sep 2023

Apply to this trial

Electrical DN as an Adjunct to Eccentric Exercise, Stretching + MT for Achilles Tendinopathy

for Achilles Tendinopathy

1 location in Columbia

Sponsor: Alabama Physical Therapy & Acupuncture

Sex: All·Age: 18+

Code: NCT03968614·Recruiting·Listed May 2019

Apply to this trial