Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Conditions

• Intracranial Atherosclerotic Stenosis (ICAS)
• Stroke

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• MRI — OTHER
  Additional MRI to the CAPTIVA study at baseline and 12 months follow-up

Study Details

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

Key Dates

First listed

Jun 18, 2023

Start date

Jun 24, 2024

Status verified

Jul 2026

Primary completion

Mar 31, 2029

Completion

Mar 31, 2029

Study Design

Enrollment

300 participants (estimated)

Arms

• Arm: CAPTIVA-MRI Group
  CAPTIVA patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.

Primary Outcome Measure

Establish ICAS hemodynamic and plaque MRI biomarkers as reliable predictors of recurrent ischemic stroke in the vascular territory of the index stroke. [ Time Frame: 12 months ]

Central Contacts

• Ka-Ho Wong
  801-585-7575
  [email protected]
• Amy Sulken
  [email protected]

Locations (28)

Find similar trials in Birmingham, AL

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