Non-small cell lung cancer (NSCLC) Clinical Trials in Houston, TX

As of October 2026, 111 paid clinical trials are recruiting for Non-small cell lung cancer (NSCLC) in Houston, Texas. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: October 16, 2026.

Related specialties in Houston

Oncology· 1,538 Lung oncology· 163

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112 clinical trials for Non-small cell lung cancer (NSCLC)

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Email me when a new non-small cell lung cancer (nsclc) trial opens in Houston, TX.

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

Sites in Houston, Tyler +24 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting·Listed May 2018

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A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

for Breast Cancer

Sites in Houston, Dallas +3 more locations

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06695845·Phase 2·Recruiting·Listed Nov 2024

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A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

for Colorectal Neoplasms

Sites in Houston, San Antonio +19 more locations

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT06131840·Phase 1·Recruiting·Listed Nov 2023

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KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

for Carcinoma, Non-Small-Cell Lung

Sites in Houston +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165070·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for Carcinoma, Non-Small-Cell Lung

Sites in Houston +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165798·Recruiting·Listed Nov 2019

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A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies

for NSCLC

Drug: EP0031

Sites in Houston +14 more locations

Sponsor: Ellipses Pharma

Sex: All·Age: 18+

Code: NCT05443126·Phase 1, Phase 2·Recruiting·Listed Jul 2022

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A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for Urothelial Carcinoma Bladder

Sites in Houston +13 more locations

Sponsor: Aktis Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07020117·Phase 1·Recruiting·Listed Jun 2025

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A Phase 1 Study of LNCB74 in Advanced Solid Tumors

for Ovarian Cancer

Sites in Houston, San Antonio +11 more locations

Sponsor: NextCure, Inc.

Sex: All·Age: 18+

Code: NCT06774963·Phase 1·Recruiting·Listed Jan 2025

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Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

for Non-Small Cell Lung Cancer

Drug: Bevacizumab

Sites in Houston, Austin +18 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT05005403·Phase 1·Recruiting·Listed Aug 2021

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A Study of LY4175408 in Participants With Advanced Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY4175408

Sites in Houston +14 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07046923·Phase 1·Recruiting·Listed Jul 2025

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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for Non-small Cell Lung Cancer (NSCLC)

Sites in Houston, San Antonio +15 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06040541·Phase 1·Recruiting·Listed Sep 2023

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Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

for Non-small Cell Lung Cancer (NSCLC)

Sites in Houston, Austin +10 more locations

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT07154706·Phase 3·Recruiting·Listed Sep 2025

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Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

for Non-small Cell Lung Cancer (NSCLC)

Sites in Houston, Austin +19 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05379985·Phase 1, Phase 2·Recruiting·Listed May 2022

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BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for Non-Small Cell Lung Cancer

Sites in Houston, San Antonio +14 more locations

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06917079·Phase 1·Recruiting·Listed Apr 2025

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Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

for PDAC

Sites in Houston, Irving +16 more locations

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06922591·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

for Oncology

Sites in Houston +12 more locations

Sponsor: Nested Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06326411·Phase 1·Recruiting·Listed Mar 2024

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

Drug: FMC-376

Sites in Houston, San Antonio +10 more locations

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

Sites in Houston +14 more locations

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

for Head and Neck Carcinoma

Sites in Houston +13 more locations

Sponsor: VM Oncology, LLC

Sex: All·Age: 18 - 80

Code: NCT03556228·Phase 1, Phase 2·Recruiting·Listed Jun 2018

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A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

for Solid Tumor, Adult

Sites in Houston +12 more locations

Sponsor: GV20 Therapeutics

Sex: All·Age: 18+

Code: NCT05669430·Phase 1, Phase 2·Recruiting·Listed Dec 2022

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A Study of NX-1607 in Adults With Advanced Malignancies

for Ovarian Cancer, Epithelial

Sites in Houston +8 more locations

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05107674·Phase 1·Recruiting·Listed Nov 2021

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A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

for Advanced Solid Tumor

Sites in Houston +9 more locations

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07629960·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

for Epidermal Growth Factor

Sites in Houston, San Antonio +4 more locations

Sponsor: EpiBiologics

Sex: All·Age: 18+

Code: NCT07462377·Phase 1·Recruiting·Listed Mar 2026

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Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

for Advanced Solid Tumors

Drug: Ivonescimab

Sites in Houston, San Antonio +7 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT07397338·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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Intratumoral N17350 in Advanced Solid Tumors

for Neoplasms, Solid Tumor

Sites in Houston +5 more locations

Sponsor: Onchilles Pharma Inc

Sex: All·Age: 18+

Code: NCT07339176·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for Biliary Tract Cancer

Sites in Houston, San Antonio +4 more locations

Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All·Age: 18+

Code: NCT06239194·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

for Ovarian Neoplasms

Sites in Houston +10 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06400472·Phase 1·Recruiting·Listed May 2024

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Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for Tumor Skin

Sites in Houston +7 more locations

Sponsor: Obsidian Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06060613·Phase 1, Phase 2·Recruiting·Listed Sep 2023

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First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for Non-Small Cell Lung Cancer

Sites in Houston +8 more locations

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06043817·Phase 1, Phase 2·Recruiting·Listed Sep 2023

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An External Control Arm Study in Non-Small Cell Lung Cancer

for Non Small Cell Lung Cancer

Sites in Houston +10 more locations

Sponsor: N-Power Medicine

Sex: All·Age: 18+

Code: NCT07174388·Recruiting·Listed Sep 2025

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FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

for Non-Small Cell Lung Cancer

Sites in Houston +4 more locations

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT07216105·Phase 1·Recruiting·Listed Oct 2025

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Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

for Non-small Cell Lung Cancer (NSCLC)

Sites in Houston +1 more location

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06567015·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer

for Non Small Cell Lung Cancer

Sites in Houston +9 more locations

Sponsor: N-Power Medicine

Sex: All·Age: 18+

Code: NCT07028489·Recruiting·Listed Jun 2025

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A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)

for Non Small Cell Lung Cancer

1 location in Houston

Sponsor: Shanghai Henlius Biotech

Sex: All·Age: 18+

Code: NCT06907615·Phase 2·Recruiting·Listed Apr 2025

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TT-4 and TT-10 as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors and Pleural Mesothelioma

for Renal Cell Cancer

Sites in Houston +1 more location

Sponsor: Portage Biotech

Sex: All·Age: 18+

Code: NCT04969315·Phase 1, Phase 2·Recruiting·Listed Jul 2021

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A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Sites in Houston +10 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07111520·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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A Study of MGC026 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Houston +6 more locations

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06242470·Phase 1·Recruiting·Listed Feb 2024

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Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

for Pancreatic Ductal Adenocarcinoma

Sites in Houston +8 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06562192·Phase 1·Recruiting·Listed Aug 2024

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Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Sites in Houston +5 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT05142189·Phase 1·Recruiting·Listed Dec 2021

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A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

for High-grade Serous Ovarian Carcinoma (HGSOC)

Sites in Houston +4 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06476808·Phase 1·Recruiting·Listed Jun 2024

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