Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

for Homozygous Familial Hypercholesterolemia

4 locations incl. Park Ridge

Sponsor: Arrowhead Pharmaceuticals

Sex: All·Age: 12+

Code: NCT07037771·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of IMG-007 in Adult Participants With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis

16 locations incl. Lancaster

Sponsor: Inmagene LLC

Sex: All·Age: 18 - 74

Code: NCT07037901·Phase 2·Recruiting

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An Observational Study of Individuals With Isolated Dystonia

for Isolated/Primary Dystonia That Affects More Than One Region of the Body

29 locations incl. Scottsdale

Sponsor: Vima Therapeutics

Sex: All·Age: 12 - 65

Code: NCT07111663·Recruiting

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A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis

for Knee Osteoarthritis

3 locations incl. Tucson

Sponsor: 4Moving Biotech

Sex: All·Age: 40 - 80

Code: NCT07225829·Phase 2·Recruiting

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A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers.

for Pressure Ulcer, Stage IV

9 locations incl. Phoenix

Sponsor: Biocomposites Ltd

Sex: All·Age: 18+

Code: NCT06283979·Phase 2·Recruiting

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Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

for Hypertension, Pulmonary

4 locations incl. O'Fallon

Sponsor: Eko Devices, Inc.

Sex: All·Age: 18+

Code: NCT07087613·Recruiting

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REgulatory T Cell Therapy to Achieve Immunosuppression REduction

for Kidney Transplantation

3 locations incl. Phoenix

Sponsor: Singulera Therapeutics Inc.

Sex: All·Age: 18 - 65

Code: NCT06552169·Phase 2·Recruiting

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

20 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

19 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

for Bipolar Disorder Type I With Mania or Mania With Mixed Features

Drug: KarXT

28 locations incl. Little Rock

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT06951711·Phase 3·Recruiting

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VIZ ACCESS HCM - Multi-Site Registry

for Hypertrophic Cardiomyopathy

3 locations incl. Atlanta

Sponsor: Viz.ai, Inc.

Sex: All·Age: 18+

Code: NCT07103057·Recruiting

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Testing Educational Modalities for Temporomandibular Disorders Curriculum

for Confidence

1 location in Downers Grove

Sponsor: Midwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07203456·Recruiting

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

138 locations incl. Berkeley

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2·Recruiting

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Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

for Childhood Fibrolamellar Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 39

Code: NCT06620302·Phase 1, Phase 2·Recruiting

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Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

for Hidradenitis Suppurativa

Drug: Ruxolitinib

67 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06958211·Phase 3·Recruiting

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Examination of Nociscan Impact on Discogenic Low Back Pain Surgical Outcomes

for Discogenic Low Back Pain

8 locations incl. Beverly Hills

Sponsor: Aclarion

Sex: All·Age: 18 - 70

Code: NCT06661850·Recruiting

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A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

34 locations incl. Laguna Hills

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06943872·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

for Bipolar-I Disorder With Mania or Mania With Mixed Features

Drug: KarXT

22 locations incl. Bentonville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT06951698·Phase 3·Recruiting

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A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

for Diabetes Mellitus, Type 1

1 location in Chicago

Sponsor: Otsuka Pharmaceutical Factory, Inc.

Sex: All·Age: 35 - 65

Code: NCT06575426·Phase 1, Phase 2·Recruiting

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Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

9 locations incl. Park Ridge

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Cohort B: paridiprubart

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701669·Phase 2·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06703073·Phase 2·Recruiting

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REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

for Angelman Syndrome

15 locations incl. Los Angeles

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 50

Code: NCT06914609·Phase 3·Recruiting

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The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

for Bronchiectasis

80 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT06872892·Phase 3·Recruiting

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ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

for Autosomal Dominant Polycystic Kidney Disease

35 locations incl. Garden Grove

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18 - 55

Code: NCT06902558·Phase 2·Recruiting

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Mood Effects of Serotonin Agonists: Depression

for LSD

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07017478·EARLY_Phase 1·Recruiting

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A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort

for Chronic Kidney Disease

5 locations incl. Glendale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07024823·Phase 1·Recruiting

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XL092 for the Treatment of Locally Advanced or Metastatic Radioiodine Refractory Differentiated Thyroid Cancer

for Locally Advanced Differentiated Thyroid Gland Carcinoma

2 locations incl. Torrance

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06959641·Phase 2·Recruiting

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Our Voices Matter: Intervention for Depression in Youth

for Depressive Symptoms

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 15 - 20·Accepts healthy volunteers

Code: NCT07216326·Recruiting

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Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

for Acute Leukemia of Ambiguous Lineage

Drug: Venetoclax

112 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 365 Days

Code: NCT06317662·Phase 2·Recruiting

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

200 locations incl. Gilbert

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06992427·Phase 3·Recruiting

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Testing the Effectiveness and Implementation of a Meditation App for Youth in the Legal System

for Behavioral Health

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13 - 20·Accepts healthy volunteers

Code: NCT06997120·Recruiting

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Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer

for Non Small Cell Lung Cancer

8 locations incl. Monterey

Sponsor: N-Power Medicine

Sex: All·Age: 18+

Code: NCT07028489·Recruiting

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A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

for Leukemia, Myeloid, Acute

Drug: Venetoclax

50 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06852222·Phase 3·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

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A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

315 locations incl. Athens

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting

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INTEGRATED CHILDHOOD ACTIVITY AND NUTRITION (ICAN) STUDY

for Achievement

1 location in Bloomington

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 6 - 11·Accepts healthy volunteers

Code: NCT07011602·Recruiting

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Effects of Effera Human Lactoferrin at One Dose Compared to Placebo on Gut Permeability

for Gut Permeability

1 location in Addison

Sponsor: Helaina Inc.

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07035964·Recruiting

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Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

for Persistent Atrial Fibrillation

32 locations incl. Mobile

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06735534·Recruiting

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Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

for Non-Muscle Invasive Bladder Urothelial Carcinoma

132 locations incl. Fayetteville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06770582·Phase 2·Recruiting

Apply to this trial