Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

for Niemann-Pick Diseases

Sites in Chicago +4 more locations

Sponsor: Sanofi

Sex: All·Age: Up to 2

Code: NCT06192576·Recruiting·Listed Jan 2024

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Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).

for Orofacial Myofunctional Disorders

2 locations in Chicago

Sponsor: Myo Munchee (Operations) Pty Ltd

Sex: All·Age: 3 - 5·Accepts healthy volunteers

Code: NCT07088055·Recruiting·Listed Jul 2025

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Non-Invasive Quantification of Liver Health in NASH (N-QUAN)

for NASH - Nonalcoholic Steatohepatitis

Sites in Chicago +5 more locations

Sponsor: Perspectum

Sex: All·Age: 18 - 75

Code: NCT04054310·Recruiting·Listed Aug 2019

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Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.

for Advanced Adenocarcinoma

Sites in Chicago +8 more locations

Sponsor: BioAtla, Inc.

Sex: All·Age: 18+

Code: NCT05808634·Phase 1·Recruiting·Listed Apr 2023

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Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head-Neck Cancer

for Head Neck Cancer

1 location in Chicago

Sponsor: Coordination Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05838729·Phase 1, Phase 2·Recruiting·Listed May 2023

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Evaluate the Continued Safety and Performance of the Foot and Ankle Products

for Hyperpronated Foot

Sites in Chicago +2 more locations

Sponsor: Arthrex, Inc.

Sex: All·Age: 2+·Accepts healthy volunteers

Code: NCT04715139·Recruiting·Listed Jan 2021

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Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease

for Alzheimer Disease

1 location in Evanston

Sponsor: CereMark Pharma, LLC

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT06254469·Phase 3·Recruiting·Listed Feb 2024

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Abbott Vascular Medical Device Registry

for Acute Myocardial Infarction

Sites in Chicago +6 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT04573660·Recruiting·Listed Oct 2020

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Probiotics in Adults With Rheumatoid Arthritis

for Rheumatoid Arthritis (RA)

1 location in Chicago

Sponsor: Ancilia Biosciences

Sex: All·Age: 18+

Code: NCT07304505·Recruiting·Listed Dec 2025

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Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source

for Pancreatic Cancer

Sites in Oak Lawn +1 more location

Sponsor: CivaTech Oncology

Sex: All·Age: 18+

Code: NCT02843945·Phase 1, Phase 2·Recruiting·Listed Jul 2016

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A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

for Sickle Cell Disease

1 location in Chicago

Sponsor: EpiDestiny, Inc.

Sex: All·Age: 18+

Code: NCT04055818·Phase 1·Recruiting·Listed Aug 2019

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Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants

for Anal High-grade Squamous Intraepithelial Lesion

Sites in Chicago +1 more location

Sponsor: Frantz Viral Therapeutics, LLC

Sex: All·Age: 18+

Code: NCT06206564·Phase 2·Recruiting·Listed Jan 2024

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An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics

for Hyperammonemia

Sites in Chicago +4 more locations

Sponsor: RECORDATI GROUP

Sex: All·Age: All ages

Code: NCT05040178·Recruiting·Listed Sep 2021

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A Multi-Country Observational Study of Safety and Effectiveness of Elfabrio® in Fabry Patients

for Fabry Disease

Sites in Chicago +5 more locations

Sponsor: Chiesi Farmaceutici S.p.A.

Sex: All·Age: 18+

Code: NCT06663358·Recruiting·Listed Oct 2024

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CardioFocus HeartLight Post-Approval Study

for Atrial Fibrillation

Sites in Chicago +3 more locations

Sponsor: CardioFocus

Sex: All·Age: 18+

Code: NCT03168659·Recruiting·Listed May 2017

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Physica System Total Knee Replacement Registry Study

for Osteoarthritis, Knee

Sites in Aurora +2 more locations

Sponsor: Limacorporate S.p.a

Sex: All·Age: 22+

Code: NCT03048201·Recruiting·Listed Feb 2017

Apply to this trial

Novel Stretching Device Versus Night Splints

for Plantar Fasciitis

1 location in Carterville

Sponsor: SAE Orthopedics

Sex: All·Age: 18+

Code: NCT05216679·Recruiting·Listed Jan 2022

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Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus

for Type I Diabetes

Sites in Chicago +4 more locations

Sponsor: Op-T LLC

Sex: All·Age: 18 - 50

Code: NCT06964087·Phase 2·Recruiting·Listed May 2025

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A Study to Assess the Adverse Events and How Oral ABBV-1042 Moves Through the Body of Healthy Adult Participants

for Healthy Volunteer

Drug: ABBV-1042

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07222709·Phase 1·Recruiting·Listed Oct 2025

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A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

for Neuroendocrine Tumors

Sites in Chicago +3 more locations

Sponsor: Chimeric Therapeutics

Sex: All·Age: 18 - 85

Code: NCT06055439·Phase 1, Phase 2·Recruiting·Listed Sep 2023

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Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)

for Kidney Disease

Sites in Chicago +2 more locations

Sponsor: Bodyport Inc.

Sex: All·Age: 21+

Code: NCT07059962·Recruiting·Listed Jul 2025

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Feasibility and Accuracy of a Novel Pleural Drain Gas Analyzer in Detecting Air Leaks

for Air Leak From Lung

1 location in Evanston

Sponsor: Lung Healing Technologies Inc

Sex: All·Age: 18+

Code: NCT06548386·Recruiting·Listed Aug 2024

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AlloMend Acellular Dermal Matrix Allograft in Pre-Pectoral Breast Reconstruction

for Pre-Pectoral Breast Reconstruction Following Single or Double Mastectomy

1 location in Joliet

Sponsor: AlloSource

Sex: Female·Age: 18+

Code: NCT06512259·Recruiting·Listed Jul 2024

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The Effect Cranberry-Based Products on the Female Microbiome

for Vaginal Microbiome

1 location in Chicago

Sponsor: Ocean Spray Cranberries, Inc.

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07109713·Recruiting·Listed Aug 2025

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A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma

for Advanced Hepatocellular Carcinoma

Sites in Chicago +6 more locations

Sponsor: Iterion Therapeutics

Sex: All·Age: 18+

Code: NCT05797805·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

for Amputation

Sites in Chicago +1 more location

Sponsor: Liberating Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07011420·Recruiting·Listed Jun 2025

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Postprandial Response to Fruit Juice

for Blood Glucose

1 location in Addison

Sponsor: Ocean Spray Cranberries, Inc.

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07103083·Recruiting·Listed Aug 2025

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Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

Sites in Peoria +6 more locations

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting·Listed May 2023

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Normative Data for Sweating Rate, Sweat Sodium Concentration and Sweat Sodium Loss in Female Athlete

for Sweat Rate

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: Female·Age: 13+·Accepts healthy volunteers

Code: NCT06995768·Recruiting·Listed May 2025

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M-Vizion™ Macroscopic Radiographic Study

for Revision Hip Arthroplasty

Sites in Chicago +6 more locations

Sponsor: Medacta USA

Sex: All·Age: 21 - 80

Code: NCT05721859·Recruiting·Listed Feb 2023

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Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

for Advanced Cancer

Sites in Chicago +6 more locations

Sponsor: Qurient Co., Ltd.

Sex: All·Age: 18+

Code: NCT05394103·Phase 1, Phase 2·Recruiting·Listed May 2022

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Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

for Longevity

1 location in Chicago

Sponsor: AgelessRx

Sex: All·Age: 40 - 85

Code: NCT07092618·Phase 2, Phase 3·Recruiting·Listed Jul 2025

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Effects of Effera Human Lactoferrin at One Dose Compared to Placebo on Gut Permeability

for Gut Permeability

1 location in Addison

Sponsor: Helaina Inc.

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07035964·Recruiting·Listed Jun 2025

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Assessment Intravenous Site Events During Outpatient Infusion Procedures With a Wireless Thermal Measurement Device During

for IV Infiltration

1 location in Skokie

Sponsor: Rhaeos, Inc.

Sex: All·Age: 12+

Code: NCT07009405·Recruiting·Listed Jun 2025

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Feasibility of Using the Gatorade Sports Science Institute (GSSI) Labs App for Hydration Related Outcomes

for Hydration

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07005895·Recruiting·Listed Jun 2025

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Assessment of CSF Shunt Flow and Headaches With a Thermal Measurement Device

for Hydrocephalus

1 location in Chicago

Sponsor: Rhaeos, Inc.

Sex: All·Age: 6 - 80

Code: NCT06996600·Recruiting·Listed May 2025

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Formative Usability Assessment of Wireless Thermal Anisotropy Devices

for Hydrocephalus

1 location in Chicago

Sponsor: Rhaeos, Inc.

Sex: All·Age: 5 - 80·Accepts healthy volunteers

Code: NCT06040697·Recruiting·Listed Sep 2023

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Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device

for Hydrocephalus

Sites in Chicago, Rolling Meadows +1 more location

Sponsor: Rhaeos, Inc.

Sex: All·Age: 5 - 80

Code: NCT06086561·Recruiting·Listed Oct 2023

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Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Endurance Performance

for Heart Rate Variability

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06964100·Recruiting·Listed May 2025

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A Clinical Trial to Assess Cognitive Effects of Cognitive Nutritional Supplement in General Population

for Cognition

1 location in Addison

Sponsor: Pharmavite LLC

Sex: All·Age: 25 - 65·Accepts healthy volunteers

Code: NCT06837246·Recruiting·Listed Feb 2025

Apply to this trial