Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

43 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06287775·Phase 1, Phase 2·Recruiting

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Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

for Multiple Sclerosis, Relapsing-Remitting

12 locations incl. Loma Linda

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 10 - 17

Code: NCT06408259·Phase 3·Recruiting

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CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

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NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)

for Dysmenorrhea

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18 - 35

Code: NCT06861920·Phase 4·Recruiting

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Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

for Hyperkalemia

Drug: patiromer

13 locations incl. Aurora

Sponsor: Vifor Pharma, Inc.

Sex: All·Age: 0 - 11

Code: NCT05766839·Phase 2·Recruiting

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Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

for Extensive Stage Small Cell Lung Cancer (ES-SCLC)

19 locations incl. Hot Springs

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06801834·Phase 3·Recruiting

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Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Endurance Performance

for Heart Rate Variability

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06964100·Recruiting

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Tapinarof for Cutaneous Lupus Erythematosus

for Cutaneous Lupus Erythematosus

Drug: Tapinarof

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06661213·EARLY_Phase 1·Enrolling By Invitation

Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

for Sleep Apnea Obstructive (OSA)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 60

Code: NCT06926036·Recruiting

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A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery

for Hemorrhage

9 locations incl. Torrance

Sponsor: Corza Medical GmbH

Sex: All·Age: 1 Month+

Code: NCT06664775·Phase 3·Recruiting

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A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's

for Dysphagia

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 22+

Code: NCT04664634·Phase 3·Recruiting

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Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

for Lung Non-Small Cell Carcinoma

245 locations incl. Jonesboro

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06498635·Phase 3·Recruiting

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Does Ethyl Chloride Spray Work?

for Injection Fear

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06651788·Recruiting

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Pain After Strabismus Surgery

for Strabismus

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 12

Code: NCT06689943·Phase 2·Not Yet Recruiting

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

for Low Grade Glioma

3 locations incl. Washington D.C.

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 1 - 26

Code: NCT06712875·Phase 1, Phase 2·Recruiting

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Preventative Screening and Health Coaching in a Food Insecure Population

for Cardiovascular Disease Prevention

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40 - 75

Code: NCT06907524·Not Yet Recruiting

The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

5 locations incl. New Haven

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting

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Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

for Atrial Fibrillation (AF)

6 locations incl. Hartford

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT06957366·Recruiting

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Prophylactic Conjoint Tendon Lengthening During Reverse Shoulder Arthroplasty Outcomes

for Osteoarthritis Shoulder

1 location in Maywood

Sponsor: Nickolas Garbis

Sex: All·Age: 18+

Code: NCT06729983·Recruiting

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CT-95 in Advanced Cancers Associated With Mesothelin Expression

for Mesothelin-Expressing Tumors

9 locations incl. Denver

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06756035·Phase 1·Recruiting

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A Study of PHST001 in Advanced Solid Tumors

for Advanced Solid Tumors

20 locations incl. Beverly Hills

Sponsor: Pheast Therapeutics

Sex: All·Age: 18+

Code: NCT06840886·Phase 1·Recruiting

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A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

for Advanced Solid Tumors Cancer

11 locations incl. Los Angeles

Sponsor: Nimbus Wadjet, Inc.

Sex: All·Age: 18 - 99

Code: NCT06898450·Phase 1, Phase 2·Recruiting

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BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for Non-Small Cell Lung Cancer

16 locations incl. Los Angeles

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06917079·Phase 1·Recruiting

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A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

for Colitis Ulcerative

19 locations incl. Sun City

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06867094·Phase 2·Recruiting

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The Pivotal Study of RapidPulseTM Aspiration System

for Acute Ischemic Stroke

18 locations incl. Torrance

Sponsor: RapidPulse, Inc

Sex: All·Age: 18 - 80

Code: NCT06029491·Recruiting

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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

101 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting

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Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

177 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting

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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

32 locations incl. Birmingham

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting

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A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

for Elevated Blood Pressure

5 locations incl. Valley Village

Sponsor: Zona Health, Inc

Sex: All·Age: 22+

Code: NCT06843577·Recruiting

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Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

88 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

60 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting

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Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

for Advanced Solid Tumor

Drug: AI-081

19 locations incl. Birmingham

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06635785·Phase 1, Phase 2·Recruiting

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Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain

for Nephrolithiasis

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06635889·Phase 2·Recruiting

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Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

for Chronic Low-back Pain

18 locations incl. Flagstaff

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06827262·Recruiting

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

for Chronic Obstructive Pulmonary Disease (COPD)

68 locations incl. Cullman

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06878261·Phase 3·Recruiting

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Enhancing Diabetes Care: Exposome &Amp; Sensors

for Type 2 Diabetes

2 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 65

Code: NCT06989008·Recruiting

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Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

15 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

76 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting

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LinkSymphoKnee (LSK) Total Knee Replacement System Study - Ultra-congruent (UC)

for Osteoarthritis (OA) of the Knee

2 locations incl. Birmingham

Sponsor: LinkBio Corp.

Sex: All·Age: 18 - 79

Code: NCT06670651·Enrolling By Invitation

Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis

for Bacterial Conjunctivitis

38 locations incl. Little Rock

Sponsor: Baxis Pharmaceuticals, Inc.

Sex: All·Age: All ages

Code: NCT06911424·Phase 3·Recruiting

Apply to this trial