Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,971 clinical trials

↓ Download CSV

Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

for Breast Neoplasms

8 locations incl. Santa Monica

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06797635·Phase 2·Recruiting

Apply to this trial

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

for Ovarian Cancer

Drug: Bevacizumab

28 locations incl. La Jolla

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT06819007·Phase 3·Recruiting

Apply to this trial

Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)

for Burnout

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05942469·Recruiting

Apply to this trial

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

27 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting

Apply to this trial

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

for Relapsed/Refractory KMT2A-r Acute Leukemia

11 locations incl. Los Angeles

Sponsor: PedAL BCU, LLC

Sex: All·Age: 0 - 21

Code: NCT06376162·Phase 1·Recruiting

Apply to this trial

Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

for Bradycardia

7 locations incl. Avondale

Sponsor: VDI Technologies

Sex: All·Age: 18+

Code: NCT06641362·Recruiting

Apply to this trial

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

67 locations incl. Foley

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting

Apply to this trial

An Open-Label Study of Azetukalner in Major Depressive Disorder

for Major Depressive Disorder

63 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06922110·Phase 3·Enrolling By Invitation

APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

for Overactive Bladder (OAB)

10 locations incl. Birmingham

Sponsor: Medstar Health Research Institute

Sex: Female·Age: 22+

Code: NCT06797245·Recruiting

Apply to this trial

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

92 locations incl. Dothan

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819878·Phase 3·Recruiting

Apply to this trial

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

for Triple Negative Breast Neoplasms

38 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06841354·Phase 3·Recruiting

Apply to this trial

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for Clear Cell Renal Cell Carcinoma

414 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06661720·Phase 3·Recruiting

Apply to this trial

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

for Heart Failure

Drug: Dapagliflozin

194 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT06677060·Phase 3·Recruiting

Apply to this trial

Technology-Enhanced Asthma Care in Children at Clinic and Home Study

for Asthma in Children

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4+·Accepts healthy volunteers

Code: NCT06820593·Recruiting

Apply to this trial

Circadian Mechanisms, Glucose, and CV Risks in T1D

for Type 1 Diabetes (T1D)

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 50

Code: NCT06624046·Recruiting

Apply to this trial

An Intervention to Reduce Sedentary Behavior for Adults With Chronic Kidney Disease

for Chronic Kidney Disease(CKD)

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 35 - 80

Code: NCT06754280·Recruiting

Apply to this trial

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

55 locations incl. Birmingham

Sponsor: Celgene

Sex: Male·Age: 18+

Code: NCT06764485·Phase 3·Recruiting

Apply to this trial

Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA

for ANCA Associated Vasculitis (AAV)

11 locations incl. Aurora

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06868290·Phase 2·Recruiting

Apply to this trial

A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis

for Juvenile Psoriatic Arthritis

Drug: Deucravacitinib

7 locations incl. Lancaster

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 5 - 17

Code: NCT06869551·Phase 3·Recruiting

Apply to this trial

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

658 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting

Apply to this trial

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

for Metastatic Colorectal Cancer

14 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06792695·Phase 2·Recruiting

Apply to this trial

A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma

for Lymphoma

4 locations incl. Goodyear

Sponsor: VIVUS LLC

Sex: All·Age: 18+

Code: NCT06915246·Phase 2·Recruiting

Apply to this trial

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

for Limited Stage Small Cell Lung Cancer

Drug: Durvalumab

33 locations incl. Daphne

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 18+

Code: NCT06773910·Phase 2·Recruiting

Apply to this trial

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

for Urinary Bladder Neoplasms

Drug: Intismeran autogene

20 locations incl. Bakersfield

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06833073·Phase 2·Recruiting

Apply to this trial

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

for Pain

14 locations incl. Mobile

Sponsor: University of Pittsburgh

Sex: All·Age: 16 - 30

Code: NCT06374238·Recruiting

Apply to this trial

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

for Lymphoma, B-Cell

6 locations incl. Duarte

Sponsor: Umoja Biopharma

Sex: All·Age: 18+

Code: NCT06528301·Phase 1·Recruiting

Apply to this trial

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

for Psoriatic Arthritis

Drug: Zasocitinib

21 locations incl. Mesa

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06671496·Phase 3·Recruiting

Apply to this trial

Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss

for Obesity and Obesity-related Medical Conditions

Drug: Tirzepatide

1 location in Chicago

Sponsor: Nicholas Skertich

Sex: All·Age: 18 - 65

Code: NCT06734273·EARLY_Phase 1·Recruiting

Apply to this trial

Alleviant ALLAY-HFrEF Study

for Heart Failure

35 locations incl. Los Angeles

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Enrolling By Invitation

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-Resistant Prostate Cancer

12 locations incl. Palo Alto

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT06879041·Phase 1·Recruiting

Apply to this trial

Postpartum Ultrasound Evaluation to Assess Risk of Hemorrhage

for Pregnancy Related

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 17+·Accepts healthy volunteers

Code: NCT06898034·Recruiting

Apply to this trial

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

for SLE (Systemic Lupus)

7 locations incl. Redwood City

Sponsor: CRISPR Therapeutics

Sex: All·Age: 18 - 70

Code: NCT06925542·Phase 1·Recruiting

Apply to this trial

52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism

for Hypogonadism, Male

20 locations incl. Los Angeles

Sponsor: Halozyme Therapeutics

Sex: Male·Age: 12 - 17

Code: NCT06689085·Phase 3·Recruiting

Apply to this trial

Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

for Heart Failure With Reduced Ejection Fraction

5 locations incl. Walnut Creek

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT06526988·Recruiting

Apply to this trial

Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations

for Non Small Cell Lung Carcinoma

26 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06772623·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

for Psoriatic Arthritis

Drug: Tirzepatide

53 locations incl. Avondale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06864026·Phase 4·Recruiting

Apply to this trial

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

for Mantle Cell Lymphoma

Drug: Sonrotoclax

37 locations incl. Birmingham

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06742996·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

for B-Cell Non-Hodgkins Lymphoma

Drug: Glofitamab

33 locations incl. Anchorage

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06806033·Phase 2·Recruiting

Apply to this trial

Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

for APOL1-Mediated Kidney Disease

67 locations incl. Alabaster

Sponsor: AstraZeneca

Sex: All·Age: 18 - 65

Code: NCT06824987·Phase 2·Recruiting

Apply to this trial

Electrophysiological Representations of Odor Identity Study 2

for Odor Identity Ratings

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 12 - 65

Code: NCT07386236·Recruiting

Apply to this trial