Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

for Acral Lentiginous Melanoma

Drug: Ipilimumab

Sites in Peoria, Springfield +301 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04511013·Phase 2·Recruiting·Listed Aug 2020

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Chicago, Peoria +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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Oral Iron Supplementation on Alternate vs. Consecutive Days for Iron Deficiency Anemia in Pregnancy

for Iron-deficiency Anemia (IDA)

1 location in Springfield

Sponsor: Southern Illinois University

Sex: Female·Age: 18 - 45

Code: NCT06492512·Phase 4·Recruiting·Listed Jul 2024

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Implementation of Point-of-Care Pharmacogenomic Decision Support Accounting for Minority Disparities

for Information Seeking Behavior

2 locations in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT03225820·Recruiting·Listed Jul 2017

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Investigational MRI Clinical Software and Hardware

for Image, Body

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT05215132·Phase 4·Recruiting·Listed Jan 2022

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Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

for Colorectal Cancer

Sites in Chicago +1 more location

Sponsor: San Raffaele University

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05732623·Recruiting·Listed Feb 2023

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Fecal Microbiota Transplant National Registry

for Fecal Microbiota Transplantation

Sites in Chicago, Maywood +26 more locations

Sponsor: American Gastroenterological Association

Sex: All·Age: All ages

Code: NCT03325855·Recruiting·Listed Oct 2017

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HCMR Re-Imaging Study

for Hypertrophic Cardiomyopathy (HCM)

Sites in Evanston +5 more locations

Sponsor: Christopher Kramer

Sex: All·Age: 18 - 65

Code: NCT07054073·Recruiting·Listed Jul 2025

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J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

for HIV

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477588·Recruiting·Listed Jun 2024

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rTMS to Improve Cognition in Parkinson's

for Parkinson's Disease

Sites in Chicago & Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 50+

Code: NCT03836950·Phase 1, Phase 2·Recruiting·Listed Feb 2019

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Empagliflozin Treatment in Kidney Transplant Recipients

for Kidney Transplant

Drug: Empagliflozin

Sites in Hines +4 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 19+

Code: NCT06013865·Phase 4·Recruiting·Listed Aug 2023

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Chicago, Evanston +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Chicago, Downers Grove +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Chicago, Downers Grove +66 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

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Community-based Approach to Lowering Stress Through Mindfulness

for Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06987799·Recruiting·Listed May 2025

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FITting Non-invasive Tests in Lynch Syndrome Surveillance

for Colorectal Cancer

Sites in Chicago +2 more locations

Sponsor: University of Chicago

Sex: All·Age: 20 - 80

Code: NCT06898996·Recruiting·Listed Mar 2025

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IMARA for Black Male Caregivers and Girls Empowerment (IMAGE)

for Sexually Transmitted Infections (Not HIV or Hepatitis)

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13+·Accepts healthy volunteers

Code: NCT06266416·Recruiting·Listed Feb 2024

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Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start

for Contraception

Sites in Chicago +6 more locations

Sponsor: University of Utah

Sex: Female·Age: 16 - 35

Code: NCT05444582·Phase 4·Recruiting·Listed Jul 2022

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Menthol, Inflammation, and Nicotine Transition Study

for Cigarette Smoking

1 location in North Chicago

Sponsor: Rosalind Franklin University of Medicine and Science

Sex: All·Age: 21 - 85·Accepts healthy volunteers

Code: NCT06232447·Recruiting·Listed Jan 2024

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Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment

for Carcinoma, Squamous Cell

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06669572·Phase 2·Recruiting·Listed Nov 2024

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Fisetin to Reduce Senescence and Mobility Impairment in PAD

for Peripheral Arterial Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06399809·Phase 2·Recruiting·Listed May 2024

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ENhancing Exercise With LIGHT to Improve Functioning in PAD

for Peripheral Artery Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06399900·Recruiting·Listed May 2024

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SMART Exercise for PAD

for Peripheral Arterial Disease

Sites in Chicago +2 more locations

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06032065·Phase 3·Recruiting·Listed Sep 2023

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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Chicago, Peoria +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

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Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men

for HIV

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06894199·Recruiting·Listed Mar 2025

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Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 location in Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 22 - 65

Code: NCT05647044·Phase 1·Recruiting·Listed Dec 2022

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Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

Sites in Chicago +10 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting·Listed Dec 2024

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

Sites in Chicago +12 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting·Listed Dec 2016

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Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

Sites in Chicago +18 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting·Listed Mar 2021

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Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

for Salivary Gland Cancer

Sites in Chicago +12 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04620187·Phase 2·Recruiting·Listed Nov 2020

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Neuroblastoma Biology Study

for Neuroblastoma

Sites in Chicago +13 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 31 Days - 99

Code: NCT01587300·Recruiting·Listed Apr 2012

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Combination Therapy to Improve SCI Recovery.

for Spinal Cord Injuries

Sites in Chicago +1 more location

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 70

Code: NCT05563103·Recruiting·Listed Oct 2022

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Partnering With Antenatal Navigators to Transform Health in Pregnancy

for Maternal Morbidity

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 16 - 50

Code: NCT06941974·Recruiting·Listed Apr 2025

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Prospective Assessments Following Immediate Lymphatic Reconstruction

for Lymphatic Reconstruction

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07227467·Recruiting·Listed Nov 2025

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Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 21+

Code: NCT03401762·Recruiting·Listed Jan 2018

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Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

Sites in Chicago +4 more locations

Sponsor: Dwight Owen

Sex: All·Age: 18+

Code: NCT04919382·Phase 2·Recruiting·Listed Jun 2021

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Hybrid Type I Effectiveness-Implementation Trial of a Social Network Support Intervention

for HIV Seropositivity

Sites in Chicago +6 more locations

Sponsor: University of Chicago

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05723653·Recruiting·Listed Feb 2023

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The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

for Influenza

Sites in Chicago +1 more location

Sponsor: University of Colorado, Denver

Sex: All·Age: 6 Months - 99·Accepts healthy volunteers

Code: NCT05832307·Recruiting·Listed Apr 2023

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Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial

for Lymphoma

Sites in Alton +43 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05006482·Phase 3·Recruiting·Listed Aug 2021

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Reducing Disparities in Urinary Control Symptoms for Minority Women

for Urinary Incontinence (UI)

2 locations in Chicago

Sponsor: University of Chicago

Sex: Female·Age: 18+

Code: NCT06798311·Recruiting·Listed Jan 2025

Apply to this trial