Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Durometer for Measuring Uterine Tone

for Uterine Tone Disorders

1 location in Chicago

Sponsor: University of Chicago

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06284421·Recruiting

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An Observational Study Comparing Delandistrogene Moxeparvovec (ELEVIDYS) With Standard of Care in Participants With Duchenne Muscular Dystrophy

for Duchenne Muscular Dystrophy

25 locations incl. Little Rock

Sponsor: Sarepta Therapeutics, Inc.

Sex: Male·Age: 4+

Code: NCT06270719·Enrolling By Invitation

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

for Metastatic Dedifferentiated Liposarcoma

Drug: Peposertib

16 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05711615·Phase 1·Recruiting

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Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

for Follicular Lymphoma (FL)

Drug: Epcoritamab

58 locations incl. Fresno

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT06191744·Phase 3·Recruiting

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Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: National Jewish Health

Sex: All·Age: 6+

Code: NCT06262282·Enrolling By Invitation

Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

for Hypertension

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18 - 99

Code: NCT06504914·Recruiting

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Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

for Muscle Invasive Bladder Urothelial Carcinoma

491 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05987241·Phase 2, Phase 3·Recruiting

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Oxygenation in Vascular Lesions of the Colon

for Vascular Lesion

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06230731·Recruiting

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Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

for Exocrine Pancreatic Insufficiency

6 locations incl. Los Angeles

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06477159·Phase 4·Recruiting

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Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis

19 locations incl. La Mesa

Sponsor: Cumberland Pharmaceuticals

Sex: All·Age: 40+

Code: NCT05571059·Phase 2·Recruiting

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Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial

for Dementia

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 45+

Code: NCT05607732·Recruiting

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Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

for Glioblastoma

19 locations incl. Phoenix

Sponsor: CarThera

Sex: All·Age: 18+

Code: NCT05902169·Phase 3·Recruiting

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Nasal Antisepsis for C. Auris Prevention

for Candida Auris Infection

3 locations incl. Chicago

Sponsor: Mary K Hayden

Sex: All·Age: 18+

Code: NCT06282510·Phase 4·Recruiting

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Mobile Health for Adherence in Breast Cancer Patients

for Anatomic Stage IV Breast Cancer AJCC v8

499 locations incl. Fairbanks

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06112613·Recruiting

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Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

for Schizophrenia

47 locations incl. Phoenix

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 5 - 17

Code: NCT06229210·Phase 3·Recruiting

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Quantitative Assessment of Autologous Fat Transfer

for Autologous Fat Grafting

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06343831·Recruiting

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Bupivacaine Hydrochloride for Pain Control in Cutaneous Surgery

for Pain, Postoperative

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT04260854·Phase 1·Enrolling By Invitation

Effects of TNF Blockade on Human BPH/LUTS

for Benign Prostatic Hyperplasia (BPH)

1 location in Glenview

Sponsor: Endeavor Health

Sex: Male·Age: 45 - 80

Code: NCT06062875·Phase 2·Recruiting

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A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

for Multiple Myeloma

Drug: Talquetamab

49 locations incl. Clovis

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06208150·Phase 3·Recruiting

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A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

for Anal Fistula

9 locations incl. Los Angeles

Sponsor: RedDress Ltd.

Sex: All·Age: 18+

Code: NCT05641844·Recruiting

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A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

for Phenylketonuria (PKU)

11 locations incl. Aurora

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT06305234·Recruiting

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Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

for Newly Diagnosed Glioblastoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05864534·Phase 2·Recruiting

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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

for Heart Failure

Drug: Finerenone

77 locations incl. Birmingham

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06008197·Phase 3·Recruiting

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A Study of Communication Between Clinicians, Patients, and Families in the Intensive Care Unit (ICU)

for Acute Respiratory Failure

5 locations incl. Chicago

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06042621·Enrolling By Invitation

Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease

for Chronic Kidney Diseases

Drug: Dapagliflozin

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05719714·Phase 1, Phase 2·Recruiting

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A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).

for Intestinal Failure Associated Liver Disease

13 locations incl. Scottsdale

Sponsor: NorthSea Therapeutics B.V.

Sex: All·Age: 16+

Code: NCT05919680·Phase 2·Recruiting

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Prostate Single Port & Laser Enucleation Comparison Trial

for Prostate Hyperplasia

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Male·Age: 18 - 88

Code: NCT06224218·Recruiting

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Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial

for Metastatic Digestive System Neuroendocrine Tumor G1

33 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05773274·Phase 2·Recruiting

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Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants

for Anal High-grade Squamous Intraepithelial Lesion

2 locations incl. Chicago

Sponsor: Frantz Viral Therapeutics, LLC

Sex: All·Age: 18+

Code: NCT06206564·Phase 2·Recruiting

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VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain

for Pain, Chronic

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06336447·Recruiting

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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

for Metastatic Head-and-neck Squamous-cell Carcinoma

28 locations incl. Gilbert

Sponsor: AVEO Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06064877·Phase 3·Recruiting

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A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Drug: Livmoniplimab

13 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06109272·Phase 2, Phase 3·Recruiting

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LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

for Pulmonary Hypertension

41 locations incl. Tucson

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT05983250·Phase 3·Recruiting

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Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

for Ulcerative Colitis

13 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05987852·Recruiting

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5-SENSE Score Validation Study

for Epilepsy Intractable

4 locations incl. Gainesville

Sponsor: Duke University

Sex: All·Age: 15+

Code: NCT06138808·Enrolling By Invitation

Prospective Validation Study of High Volume Urine DNA Testing in Individuals With Suspicion of Urothelial Cancer

for Urothelial Carcinoma

1 location in Chicago

Sponsor: Tampere University Hospital

Sex: All·Age: 18 - 100

Code: NCT06310759·Recruiting

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JAG201 Gene Therapy Study in Children & Adults With SHANK3 Haploinsufficiency

for SHANK3 Haploinsufficiency

3 locations incl. Chicago

Sponsor: Jaguar Gene Therapy, LLC

Sex: All·Age: 2 - 9

Code: NCT06662188·Phase 1, Phase 2·Recruiting

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Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients

for Acute Kidney Injury

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05988658·Recruiting

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Using MRI to Identify Areas to Receive Lower Doses of Radiation Treatment in Men With Prostate Cancerdose Mapping to Preserve Quality of Life

for Prostate Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT06171269·Recruiting

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FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

14 locations incl. Gilbert

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting

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