Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

2,519 clinical trials

Get a weekly email when new trials open in Chicago, IL.

Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy

for Pregnancy

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18 - 60

Code: NCT06314009·Recruiting·Listed Mar 2024

Apply to this trial

NeuroVision vs Standard Neuromonitoring

for Neurologic Deficits

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04639297·Recruiting·Listed Nov 2020

Apply to this trial

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

Sites in Chicago +9 more locations

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting·Listed Mar 2023

Apply to this trial

EVR and EPO for Liver Transplant Tolerance

for Liver Transplant

Sites in Chicago +2 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06832189·Phase 1·Recruiting·Listed Feb 2025

Apply to this trial

STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission

for Ulcerative Colitis (UC)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 75

Code: NCT06693310·Recruiting·Listed Nov 2024

Apply to this trial

Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics

for Acute Pancreatitis

Sites in Chicago +12 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 75

Code: NCT06401577·Recruiting·Listed May 2024

Apply to this trial

Improving Deceased-Donor Kidney Transplant Outcomes Via a Single Intragraft Injection of C1 Esterase Inhibitor (IMPROVE TRIAL)

for Kidney Transplant

Sites in Chicago +3 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06919003·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

Sites in Chicago, Downers Grove +56 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial

Study of KM-023 in Healthy Volunteers and Patients With Olmsted Syndrome.

for Olmsted Syndrome

1 location in Chicago

Sponsor: Orvida Pharma (formerly Kamari Pharma)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07090889·Phase 1·Recruiting·Listed Jul 2025

Apply to this trial

Venetoclax Basket Trial for High Risk Hematologic Malignancies

for Myelodysplastic Syndromes, de Novo

Drug: Venetoclax

Sites in Chicago +4 more locations

Sponsor: Andrew E. Place, MD

Sex: All·Age: 1 - 40

Code: NCT05292664·Phase 1·Recruiting·Listed Mar 2022

Apply to this trial

RemI for Post-Bariatric Surgery Weight Regain

for Obesity

Sites in Chicago +1 more location

Sponsor: Temple University

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06292936·Recruiting·Listed Mar 2024

Apply to this trial

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

Sites in Chicago +5 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting·Listed Dec 2024

Apply to this trial

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

for CADASIL

Sites in Chicago +11 more locations

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05677880·Recruiting·Listed Jan 2023

Apply to this trial

Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants

for Infant, Premature, Diseases

2 locations in Maywood

Sponsor: Loyola University

Sex: All·Age: 23 Weeks - 32 Weeks

Code: NCT07216664·Recruiting·Listed Oct 2025

Apply to this trial

Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

for Grade 3b Follicular Lymphoma

Sites in Chicago, Urbana +97 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05890352·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

for Failed or Difficult Intubation, Sequela

Sites in Chicago +50 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT02493478·Recruiting·Listed Jul 2015

Apply to this trial

JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

Sites in Chicago +15 more locations

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting·Listed Mar 2025

Apply to this trial

BMT-06: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI)

for Acute Leukemia

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 75

Code: NCT04187105·Phase 2·Recruiting·Listed Dec 2019

Apply to this trial

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

Sites in Evanston +15 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

Apply to this trial

Supporting Caregivers Following Mental Health Emergency Department Visits

for Caregiver Participation

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 10 - 17

Code: NCT07411300·Recruiting·Listed Feb 2026

Apply to this trial

The APS Phenotyping Study

for ARDS

Sites in Chicago +19 more locations

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06521502·Recruiting·Listed Jul 2024

Apply to this trial

Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

for Prostate Cancer

Sites in Shiloh +45 more locations

Sponsor: Canadian Cancer Trials Group

Sex: Male·Age: 18+

Code: NCT06235697·Phase 3·Recruiting·Listed Feb 2024

Apply to this trial

Optimization of NIBS for Treatment of Addiction

for Opioid-use Disorder

Sites in Hinsdale +2 more locations

Sponsor: Case Western Reserve University

Sex: All·Age: 18 - 85

Code: NCT04379115·Recruiting·Listed May 2020

Apply to this trial

Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A

for Von Willebrand Disease, Type 3

Sites in Peoria +11 more locations

Sponsor: Bleeding and Clotting Disorders Institute Peoria, Illinois

Sex: All·Age: 0 - 90

Code: NCT05500807·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

Vitamin D for Prostate Endocrine Therapy

for Stage I Prostate Cancer AJCC v8

Sites in Urbana, O'Fallon +49 more locations

Sponsor: University of Rochester

Sex: Male·Age: 50+

Code: NCT05838716·Phase 3·Recruiting·Listed May 2023

Apply to this trial

The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery

for Surgery

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03729180·Recruiting·Listed Nov 2018

Apply to this trial

His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

Sites in Chicago +13 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting·Listed Mar 2022

Apply to this trial

Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia

for Insomnia

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06694441·Recruiting·Listed Nov 2024

Apply to this trial

FDG-PET-Guided Metastasis Directed Radiation Therapy for the Treatment of Metastatic Hormone Sensitive Prostate Cancer, The PRTY Trial

for Castration-Sensitive Prostate Carcinoma

Sites in Chicago, Orland Park +4 more locations

Sponsor: Northwestern University

Sex: Male·Age: 18+

Code: NCT06244004·Phase 2·Recruiting·Listed Feb 2024

Apply to this trial

Hypofractionation (Radiation) Trial for Multiple Myeloma

for Multiple Myeloma

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06270888·Phase 1·Recruiting·Listed Feb 2024

Apply to this trial

Wearable Sensors to Detect Atypical Muscle Activation in Young Infants

for Neuromuscular Disorders

2 locations in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 0 Months - 8 Weeks

Code: NCT06970522·Recruiting·Listed May 2025

Apply to this trial

Luspatercept + Darbepoetin in MDS

for MDS (Myelodysplastic Syndrome)

Sites in Chicago +2 more locations

Sponsor: Yale University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07096297·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

American Lung Association (ALA) Lung Health Cohort

for Lung Diseases

Sites in Chicago +29 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT04543461·Recruiting·Listed Sep 2020

Apply to this trial

MRI Screening in Men at High Risk of Developing Prostate Cancer

for Prostate Cancer Screening

Sites in Chicago & Glenview

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT05608694·Recruiting·Listed Nov 2022

Apply to this trial

Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease

for Sickle Cell Disease

Sites in Chicago +3 more locations

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06919224·Recruiting·Listed Apr 2025

Apply to this trial

Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device

for Bleeding

Sites in Chicago +2 more locations

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT06655376·Phase 4·Recruiting·Listed Oct 2024

Apply to this trial

Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy

for Prostate Cancer

1 location in Evanston

Sponsor: Endeavor Health

Sex: Male·Age: 40 - 69

Code: NCT05295407·Recruiting·Listed Mar 2022

Apply to this trial

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

for Knee Osteoarthritis

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 21 - 79

Code: NCT06617871·Recruiting·Listed Oct 2024

Apply to this trial

Heart Transplantation - Renewal

for Transplant, Heart

2 locations in Chicago

Sponsor: Northwestern University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05521399·Recruiting·Listed Aug 2022

Apply to this trial

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

for Diabetic Nephropathies

Drug: Sotagliflozin

Sites in Chicago +12 more locations

Sponsor: Alessandro Doria

Sex: All·Age: 18 - 75

Code: NCT06217302·Phase 3·Recruiting·Listed Jan 2024

Apply to this trial