Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

for Head and Neck Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07065630·Phase 2·Recruiting·Listed Jul 2025

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Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Sites in Chicago +7 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 54

Code: NCT06918431·Phase 2·Recruiting·Listed Apr 2025

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Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

for Lung Neoplasm

Sites in Hines +13 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT02984761·Recruiting·Listed Dec 2016

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Testing the Effectiveness and Implementation of a Meditation App for Youth in the Legal System

for Behavioral Health

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13 - 20·Accepts healthy volunteers

Code: NCT06997120·Recruiting·Listed May 2025

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Eosinophilic Gastrointestinal Disorders Registry

for Eosinophilic Esophagitis

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 1 - 25

Code: NCT05199532·Recruiting·Listed Jan 2022

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A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)

for Acute Leukemia

Sites in Chicago +1 more location

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06207123·Phase 1, Phase 2·Recruiting·Listed Jan 2024

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Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma

for Mesothelioma

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07126509·Recruiting·Listed Aug 2025

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Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery

for Adult Spinal Deformity

Sites in Chicago +10 more locations

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04885244·Recruiting·Listed May 2021

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rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

for Diffuse Intrinsic Pontine Glioma

Sites in Chicago +2 more locations

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 12 Months - 18

Code: NCT04943848·Phase 1·Recruiting·Listed Jun 2021

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NPWTi on Closure of Chronic Pressure Sores

for Pressure Sore

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05598398·Phase 4·Recruiting·Listed Oct 2022

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Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

for Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT04477330·Recruiting·Listed Jul 2020

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PSMA PET for Surveillance After Focal Therapy

for Prostate Cancer (Adenocarcinoma)

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT07115914·Recruiting·Listed Aug 2025

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Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs

for Diabetes Mellitus

Sites in Chicago +2 more locations

Sponsor: California Polytechnic State University-San Luis Obispo

Sex: Female·Age: 18+

Code: NCT06988306·Recruiting·Listed May 2025

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Erector Spinae Plane Block for Acute Back Pain in the Emergency Department

for Low Back Pain

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06745453·Recruiting·Listed Dec 2024

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Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

for Respiratory Syncytial Virus Infections

Sites in Chicago +14 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 3 Days - 2

Code: NCT05026749·Phase 3·Recruiting·Listed Aug 2021

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Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

for Relapsed Small Cell Lung Cancer

Sites in Chicago +10 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06681220·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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Predictors of Behavioral Obesity Treatment Outcomes

for Obesity

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05326477·Recruiting·Listed Apr 2022

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Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease

for Sickle Cell Disease

Sites in Chicago +4 more locations

Sponsor: Robert Nickel

Sex: All·Age: 2 - 25

Code: NCT03587272·Phase 2·Recruiting·Listed Jul 2018

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Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care

for Breast Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 30+

Code: NCT05483283·Recruiting·Listed Aug 2022

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ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

for Depression

Sites in Chicago +1 more location

Sponsor: Stanford University

Sex: All·Age: 18 - 60

Code: NCT06408246·Phase 2·Recruiting·Listed May 2024

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Hemodynamic ABI Monitor

for Traumatic Brain Injury (TBI)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 80

Code: NCT06725108·Recruiting·Listed Dec 2024

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The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

for Patients Undergoing Routine Health Care

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01280825·Recruiting·Listed Jan 2011

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Detecting HPV DNA in Anal and Cervical Cancers

for Cervical Cancer

2 locations in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04857528·Recruiting·Listed Apr 2021

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Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

for Small-cell Lung Cancer

Drug: Durvalumab

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05068232·Phase 2·Recruiting·Listed Oct 2021

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Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

for Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05166694·Recruiting·Listed Dec 2021

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Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

for Head and Neck Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05526924·Phase 1·Recruiting·Listed Sep 2022

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Using MRI to Identify Areas to Receive Lower Doses of Radiation Treatment in Men With Prostate Cancerdose Mapping to Preserve Quality of Life

for Prostate Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT06171269·Recruiting·Listed Dec 2023

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KRONOS Versus Breg T-Scope Post-operative Knee Braces Following Anterior Cruciate Ligament (ACL) Reconstruction

for Anterior Cruciate Ligament (ACL) Reconstruction Surgery

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07090616·Recruiting·Listed Jul 2025

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The Myelin Disorders Biorepository Project

for Leukodystrophy

Sites in Chicago +22 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting·Listed Feb 2017

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Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Chicago, Evanston +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

Empathic Communication Skills (ECS) Training

for Lung Cancer

Sites in Libertyville +7 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05456841·Recruiting·Listed Jul 2022

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

Sites in Chicago +67 more locations

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

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Neoadjuvant Pembrolizumab and IO102-103 for Squamous Cell Carcinoma of the Head and Neck (SCCHN).

for Head and Neck Squamous Cell Carcinoma

Sites in Chicago +4 more locations

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT05977907·Phase 2·Recruiting·Listed Aug 2023

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Dysbiosis & Long COVID

for COVID-19

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06825819·Recruiting·Listed Feb 2025

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Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone

for Atrial Fibrillation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 20 - 85

Code: NCT06063538·EARLY_Phase 1·Recruiting·Listed Oct 2023

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One-Time DNA Study for Vasculitis

for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Sites in Chicago +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 7+

Code: NCT01241305·Recruiting·Listed Nov 2010

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Avo In R/R And Previously Untreated MCL

for Mantle Cell Lymphoma

Sites in Chicago +2 more locations

Sponsor: Austin I Kim

Sex: All·Age: 18+

Code: NCT04855695·Phase 1, Phase 2·Recruiting·Listed Apr 2021

Apply to this trial

MyPEEPS LITE Trial

for HIV/AIDS

Sites in Chicago +1 more location

Sponsor: Columbia University

Sex: Male·Age: 16 - 29·Accepts healthy volunteers

Code: NCT06741631·Recruiting·Listed Dec 2024

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Language in Primary Progressive Aphasia

for Primary Progressive Aphasia

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: All ages

Code: NCT00537004·Recruiting·Listed Sep 2007

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Trial of Ixazomib for Kaposi Sarcoma

for Kaposi Sarcoma

Sites in Chicago +10 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04305691·Phase 2·Recruiting·Listed Mar 2020

Apply to this trial