Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

for Heart Failure

2 locations in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06205225·Recruiting·Listed Jan 2024

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Optimizing Outcomes for Young Autistic Children

for Autism

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 18 Months - 48 Months·Accepts healthy volunteers

Code: NCT05926687·Phase 2·Recruiting·Listed Jul 2023

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Trial of FETO for Severe Congenital Diaphragmatic Hernia

for Congenital Diaphragmatic Hernia

1 location in Chicago

Sponsor: Aimen F. Shaaban, MD

Sex: Female·Age: 18+

Code: NCT05450653·Recruiting·Listed Jul 2022

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Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation

for Obstructive Sleep Apnea

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06317701·Recruiting·Listed Mar 2024

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Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

for Migraine

1 location in Oak Lawn

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06904287·Phase 3·Recruiting·Listed Apr 2025

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A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

for Chronic Pain

Sites in Chicago +6 more locations

Sponsor: Telethon Kids Institute

Sex: All·Age: Up to 16·Accepts healthy volunteers

Code: NCT06354699·Recruiting·Listed Apr 2024

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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

for Liver Diseases

Sites in Chicago +15 more locations

Sponsor: European Foundation for Study of Chronic Liver Failure

Sex: All·Age: 18 - 80

Code: NCT04613921·Recruiting·Listed Nov 2020

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Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

for Locally Advanced Hepatocellular Carcinoma

Drug: Atezolizumab

Sites in Chicago, Urbana +10 more locations

Sponsor: Academic and Community Cancer Research United

Sex: All·Age: 18+

Code: NCT05168163·Phase 2·Recruiting·Listed Dec 2021

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Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

for Barrett Esophagus

Sites in Chicago +13 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05530343·Recruiting·Listed Sep 2022

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Characterization of the Microbiome in Cutaneous T Cell Lymphoma

for Cutaneous T Cell Lymphoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT03932279·Recruiting·Listed Apr 2019

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Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 location in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 16 - 20

Code: NCT06355310·Phase 2·Recruiting·Listed Apr 2024

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LUNG-05: Investigating Chemotherapy Effectiveness for Non-Small Cell Lung Cancer (NSCLC) Metastatic Patients

for NSCLC

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06576635·Recruiting·Listed Aug 2024

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A Novel mHealth Intervention to Improve Outcomes of Children With Medical Complexity

for Children With Medical Complexity

Sites in Chicago +1 more location

Sponsor: University of Utah

Sex: All·Age: 1 - 18

Code: NCT06883045·Recruiting·Listed Mar 2025

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PiMZ Longitudinal Cohort (PiMZ Logic)

for Alpha 1-Antitrypsin Deficiency

Sites in Chicago +4 more locations

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT06505603·Recruiting·Listed Jul 2024

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Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

for Spinal Cord Injury

Sites in Chicago & Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05157282·Recruiting·Listed Dec 2021

Apply to this trial

MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease

for Liver Diseases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05264051·Recruiting·Listed Mar 2022

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

Sites in Chicago +9 more locations

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting·Listed Nov 2021

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Study to Test the Combination of Fulvestrant With Lu-DOTATATE for Advanced Pancreatic Neuroendocrine Tumors

for Metastatic Pancreatic Neuroendocrine Tumor

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06663072·Phase 1·Recruiting·Listed Oct 2024

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Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery

for Open Posterior Thoracolumbar Spinal Fusion Procedure

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT03849443·EARLY_Phase 1·Recruiting·Listed Feb 2019

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Oxalate and Citrate

for Kidney Stone

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05334979·Recruiting·Listed Apr 2022

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A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC)

for Metastatic Squamous Non-Small Cell Lung Carcinoma

Drug: Cabozantinib

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT05613413·Phase 2·Recruiting·Listed Nov 2022

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Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors

for End Stage Renal Disease

Sites in Chicago +5 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03803423·Recruiting·Listed Jan 2019

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Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

Sites in Evanston +17 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting·Listed Mar 2024

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Forceps vs. Snare IVC Filter Removal

for DVT

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04092192·Recruiting·Listed Sep 2019

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ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

for B-cell Acute Lymphoblastic Leukemia

Sites in Chicago +3 more locations

Sponsor: Marlise Luskin, MD

Sex: All·Age: 18+

Code: NCT03595917·Phase 1·Recruiting·Listed Jul 2018

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OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

for Eosinophilic Gastrointestinal Disorders (EGIDs)

Sites in Chicago +15 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 3+

Code: NCT02523118·Recruiting·Listed Aug 2015

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Intraoperative Fluorescence-Guided Aspirate Tissue Monitoring of 5-ALA During Brain Tumor Surgery

for Brain Neoplasms

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 99

Code: NCT07111182·Recruiting·Listed Aug 2025

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Rural Illinois Lung Cancer Screening Initiative

for Lung Cancer

1 location in Springfield

Sponsor: Southern Illinois University

Sex: All·Age: 50 - 80

Code: NCT06084078·Recruiting·Listed Oct 2023

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Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

for Relapsed Classic Hodgkin Lymphoma

Drug: Nivolumab

Sites in Chicago +4 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04561206·Phase 2·Recruiting·Listed Sep 2020

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Explanted Lung Tissues With Pulmonary Fibrosis

for Pulmonary Fibrosis

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT00515567·Recruiting·Listed Aug 2007

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Vasoactive Drugs in Intensive Care Unit

for Shock

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT02118467·Phase 4·Recruiting·Listed Apr 2014

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Investigating Patient Satisfaction With Smart Knee Implants

for Total Knee Arthroplasty

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06968143·Recruiting·Listed May 2025

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Investigating Periprosthetic Fracture Cultures in Arthroplasty

for Periprosthetic Fracture Around Prosthetic Joint Implant

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06952738·Recruiting·Listed May 2025

Apply to this trial

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

for Pain

Sites in Chicago +13 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 16 - 30

Code: NCT06374238·Recruiting·Listed Apr 2024

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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for Cutaneous Melanoma, Stage II

Sites in Chicago, Evanston +128 more locations

Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All·Age: 18+

Code: NCT03860883·Recruiting·Listed Mar 2019

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Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment

for Congenital Heart Disease

Sites in Chicago +4 more locations

Sponsor: Columbia University

Sex: All·Age: All ages

Code: NCT03891160·Recruiting·Listed Mar 2019

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Oxalate and Citrate in Humans - Response to Citrate

for Kidney Stone

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06944223·Recruiting·Listed Apr 2025

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The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

Sites in Chicago +34 more locations

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting·Listed May 2020

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Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology

for Hip Dysplasia

Sites in Chicago +3 more locations

Sponsor: Ottawa Hospital Research Institute

Sex: All·Age: 16 - 50

Code: NCT03481010·Recruiting·Listed Mar 2018

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Frameless Stereotactic Radiosurgery for Intact Brain Metastases

for Brain Metastases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT02747303·Phase 2·Recruiting·Listed Apr 2016

Apply to this trial