Paid Clinical Trials in Illinois

Illinois has 2,846 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

Sites in Hinsdale +26 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT05650632·Phase 1·Recruiting·Listed Dec 2022

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A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer

for Colorectal Cancer

Sites in Hinsdale +31 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06562543·Phase 4·Recruiting·Listed Aug 2024

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Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma (CSCC)

Drug: Cemiplimab

Sites in Chicago, Naperville +42 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06585410·Phase 3·Recruiting·Listed Sep 2024

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GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

for Stroke

Sites in Chicago, Evanston +29 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 70

Code: NCT03821129·Recruiting·Listed Jan 2019

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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

Drug: Nivolumab

Sites in Chicago +43 more locations

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting·Listed Feb 2024

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Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

Sites in Chicago, Peoria +67 more locations

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting·Listed Jun 2025

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A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants

for Systemic Lupus Erythematosus (SLE)

Sites in Willowbrook +24 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 16+

Code: NCT07175285·Recruiting·Listed Sep 2025

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A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

for Primary Open Angle Glaucoma

Sites in Peoria +25 more locations

Sponsor: AbbVie

Sex: All·Age: 45+

Code: NCT06822738·Phase 3·Recruiting·Listed Feb 2025

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A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Sites in Chicago, Warrenville +21 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT04302025·Phase 2·Recruiting·Listed Mar 2020

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A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

for Osteoarthritis, Knee

Sites in Chicago +40 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05986292·Phase 2·Recruiting·Listed Aug 2023

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A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

for Sickle Cell Disease

Drug: Etavopivat

Sites in Chicago +43 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 12+

Code: NCT06612268·Phase 3·Recruiting·Listed Sep 2024

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A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

for Sickle Cell Disease

Drug: Etavopivat

Sites in Chicago +10 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 2+

Code: NCT06609226·Phase 3·Recruiting·Listed Sep 2024

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Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

for Heart Failure - NYHA II - IV

Sites in Naperville, Hinsdale +38 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07069738·Recruiting·Listed Jul 2025

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CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

for Type 1 Diabetes Mellitus

Sites in Chicago, Springfield +43 more locations

Sponsor: COUR Pharmaceutical Development Company, Inc.

Sex: All·Age: 12 - 35

Code: NCT06783309·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

for Breast Cancer

Sites in Skokie, Shiloh +100 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07062965·Phase 3·Recruiting·Listed Jul 2025

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Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

for Persistent Atrial Fibrillation

Sites in Oak Lawn +32 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06735534·Recruiting·Listed Dec 2024

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Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

for High Risk Cardiovascular Disease

Drug: Zilebesiran

Sites in Chicago, Peoria +272 more locations

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07181109·Phase 3·Recruiting·Listed Sep 2025

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Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

for Chronic Obstructive Pulmonary Disease

Drug: Lunsekimig

Sites in Peoria, Normal +50 more locations

Sponsor: Sanofi

Sex: All·Age: 40 - 80

Code: NCT07190222·Phase 3·Recruiting·Listed Sep 2025

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Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

for Atherosclerotic Cardiovascular Disease (ASCVD)

Drug: Inclisiran

Sites in Park Ridge +20 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT06813911·Phase 3·Recruiting·Listed Feb 2025

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A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

for Geographic Atrophy

Sites in Lemont +44 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 60+

Code: NCT06635148·Phase 2·Recruiting·Listed Oct 2024

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A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

for Neoplasms

Sites in Chicago +24 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 1 - 39

Code: NCT05999994·Phase 2·Recruiting·Listed Aug 2023

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ELEVATE High-Risk PCI Pivotal Study

for High-Risk Percutaneous Coronary Intervention (High-risk PCI)

Sites in Chicago +32 more locations

Sponsor: Magenta Medical Ltd.

Sex: All·Age: 18 - 88

Code: NCT07001332·Recruiting·Listed Jun 2025

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A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

Sites in Chicago +35 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting·Listed Sep 2024

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A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

Sites in Chicago +29 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06203210·Phase 3·Recruiting·Listed Jan 2024

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A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease

for Parkinsons Disease (PD)

Sites in Chicago +33 more locations

Sponsor: BlueRock Therapeutics

Sex: All·Age: 45 - 75

Code: NCT06944522·Phase 3·Recruiting·Listed Apr 2025

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

for Alzheimer's Disease

Drug: KarXT

Sites in Chicago, Springfield +23 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976203·Phase 3·Recruiting·Listed May 2025

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A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

for Myelofibrosis

Sites in Chicago +29 more locations

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT04176198·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

for Progressive Pulmonary Fibrosis

Sites in Chicago, Maywood +72 more locations

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT05943535·Phase 3·Recruiting·Listed Jul 2023

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Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy

for Cancer Weight Loss

Sites in Chicago, Skokie +23 more locations

Sponsor: Endevica Bio

Sex: All·Age: 18+

Code: NCT06937177·Phase 2·Recruiting·Listed Apr 2025

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Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Low-grade NMIBC

Sites in Lisle, Chicago Ridge +34 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06995677·Phase 2·Recruiting·Listed May 2025

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Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

for Tricuspid Regurgitation

Sites in Chicago +45 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04097145·Recruiting·Listed Sep 2019

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Global Paradise System US Post Approval Study

for Hypertension

Sites in Springfield +42 more locations

Sponsor: ReCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT06297291·Recruiting·Listed Mar 2024

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SELUTION 4 De Novo Small Vessel IDE Trial

for Coronary Artery Disease

Sites in Urbana, Oak Lawn +62 more locations

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05946629·Recruiting·Listed Jul 2023

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ELEVATE-HFpEF Clinical Study

for Heart Failure With Preserved Ejection Fraction (HFpEF)

Sites in Chicago +25 more locations

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 40+

Code: NCT06678841·Recruiting·Listed Nov 2024

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

Sites in Chicago, Peoria +54 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting·Listed Aug 2024

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Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

for Non-muscle Invasive Bladder Cancer

Sites in Lake Barrington +35 more locations

Sponsor: Protara Therapeutics

Sex: All·Age: 18+

Code: NCT05951179·Phase 2·Recruiting·Listed Jul 2023

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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

for Pulmonary Hypertension

Sites in Chicago +36 more locations

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06911632·Recruiting·Listed Apr 2025

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

for Acute Respiratory Distress Syndrome (ARDS)

Sites in Peoria, Evanston +38 more locations

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06703073·Phase 2·Recruiting·Listed Nov 2024

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Bevacizumab

Sites in Peoria, Evanston +38 more locations

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701656·Phase 2·Recruiting·Listed Nov 2024

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Cohort B: paridiprubart

Sites in Peoria, Evanston +38 more locations

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701669·Phase 2·Recruiting·Listed Nov 2024

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