Paid Clinical Trials in Illinois

Illinois has 2,968 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 18, 2026.

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2,968 clinical trials

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An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for Stomatitis

20 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07357597·Phase 4·Not Yet Recruiting

Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy

for Autoimmune Disorders

8 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT07103746·Phase 2·Recruiting

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Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

for Advanced Hepatocellular Carcinoma

107 locations incl. Berkeley

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07166406·Phase 3·Recruiting

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Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

for Primary Sjogren's Disease

Drug: Telitacicept

26 locations incl. Chandler

Sponsor: Vor Biopharma

Sex: All·Age: 18 - 75

Code: NCT07404865·Phase 3·Recruiting

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Zinc Supplementation With Botulinum Toxin for Overactive Bladder

for Overactive Bladder (OAB)

1 location in Skokie

Sponsor: Endeavor Health

Sex: Female·Age: 21 - 100

Code: NCT07405554·Phase 2·Recruiting

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A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants

for Healthy Volunteer

Drug: Upadacitinib

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07425899·Phase 1·Recruiting

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Intravascular Neuro OCT Imaging System for Aneurysm Treatment Evaluation

for Intracranial Aneurysm

6 locations incl. Jacksonville

Sponsor: Spryte Medical

Sex: All·Age: 18 - 75

Code: NCT07214220·Recruiting

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Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

for HIV-1-infection

11 locations incl. Los Angeles

Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07293559·Recruiting

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

22 locations incl. Miramar

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting

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Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

for Relapsed Small Cell Lung Cancer

11 locations incl. Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06681220·Phase 1, Phase 2·Recruiting

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A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

for Relapsed Refractory Multiple Myeloma

48 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07391657·Phase 3·Recruiting

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An Open-Label Extension Study of ORKA-001 in Participants With Plaque Psoriasis

for Plaque Psoriasis

16 locations incl. Fountain Valley

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07449702·Phase 2·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer

for Locally Advanced Adrenal Cortical Carcinoma

Drug: Cabozantinib

69 locations incl. La Jolla

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT06900595·Phase 2·Recruiting

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Mobilizing Community Hypertension Access Pilot

for Hypertension

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07547345·Recruiting

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A Clinical Study to Evaluate the Efficacy and Safety of Ultra in Promoting Hair Regrowth

for Androgenic Alopecia

2 locations incl. Glenview

Sponsor: CynosureLutronic

Sex: All·Age: 22 - 70

Code: NCT07588243·Recruiting

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A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

41 locations incl. Los Angeles

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07435428·Phase 3·Recruiting

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Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement

for Healthy Adult

1 location in Addison

Sponsor: Shaklee Corporation

Sex: All·Age: 45 - 65·Accepts healthy volunteers

Code: NCT07428889·Recruiting

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Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

for Pregnancy

8 locations incl. Los Angeles

Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Sex: Female·Age: All ages

Code: NCT07207876·Recruiting

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A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

65 locations incl. Alabaster

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07220083·Phase 3·Recruiting

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Empower EI: Comparing Early Intervention Approaches to Improve Communication in Toddlers With Developmental Delays

for Developmental Delays

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 12 Months - 31 Months

Code: NCT07227974·Recruiting

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A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain

for Diabetic Peripheral Neuropathic Pain

Drug: LY4065967

36 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07285018·Phase 2·Recruiting

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COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

50 locations incl. Bakersfield

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449936·Phase 3·Recruiting

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

18 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting

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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

for Ampulla of Vater Carcinoma

309 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283939·Recruiting

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Aspiration Thrombectomy Using the Symphony or Prodigy System

for Arterial Thromboembolism

2 locations incl. Huntsville

Sponsor: Imperative Care, Inc.

Sex: All·Age: 18+

Code: NCT07350499·Recruiting

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A Study of Brenipatide in Participants With Opioid Use Disorder

for Opioid Use Disorder

Drug: Brenipatide

38 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07420283·Phase 2·Recruiting

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A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

31 locations incl. Chandler

Sponsor: Rivus Pharmaceuticals, Inc.

Sex: All·Age: 30+

Code: NCT07491458·Phase 2·Recruiting

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Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

for Chronic Obstructive Pulmonary Disease (COPD)

Drug: Omalizumab

23 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 40+

Code: NCT07059091·Phase 2·Recruiting

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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for Carcinoma, Renal Cell

Drug: PF-08634404

101 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227415·Phase 1, Phase 2·Recruiting

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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

for Overweight

Drug: Eloralintide

54 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07392190·Phase 3·Recruiting

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A Multicenter, Randomized, Double-Masked, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of ZOC2017217 in Subjects With Age-Related Cataract

for Age Related Cataracts

21 locations incl. Scottsdale

Sponsor: Ocusun Ophthalmic Pharmaceutical (Guangzhou) Co., Ltd.

Sex: All·Age: 50+

Code: NCT07395986·Phase 2·Enrolling By Invitation

A Study of Brenipatide in Adult Participants With Schizophrenia

for Schizophrenia

Drug: Brenipatide

31 locations incl. Little Rock

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 55

Code: NCT07410507·Phase 2·Recruiting

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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

for Osteoarthritis

Drug: Eloralintide

37 locations incl. Mobile

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07353931·Phase 3·Recruiting

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A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout

for Uncontrolled Gout

48 locations incl. Birmingham

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07388498·Phase 3·Recruiting

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CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

48 locations incl. Gilbert

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449923·Phase 3·Recruiting

Apply to this trial

Exercise and Protein Efficiency in T2D

for Type 2 Diabetes

1 location in Urbana

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07477067·Recruiting

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

29 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07266441·Phase 2·Recruiting

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A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System

for Post Traumatic Arthritis

4 locations incl. Morton Grove

Sponsor: Stryker Trauma and Extremities

Sex: All·Age: 21+

Code: NCT07118501·Recruiting

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A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects

for Multiple Myeloma (MM)

Drug: Elranatamab

16 locations incl. Gilbert

Sponsor: C4 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07280013·Phase 1·Recruiting

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A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus

for Type II Diabetes Mellitus

31 locations incl. Birmingham

Sponsor: Corxel Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT07340320·Phase 2·Recruiting

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