Oncology Clinical Trials in Iowa City, IA

As of July 2026, 105 paid clinical trials are recruiting for Oncology in Iowa City, Iowa. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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106 clinical trials for Oncology

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Iowa City, Council Bluffs +471 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Iowa City, Des Moines +209 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

1 location in Iowa City

Sponsor: Kittika Poonsombudlert

Sex: All·Age: 18 - 75

Code: NCT07177079·Phase 1·Recruiting·Listed Sep 2025

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Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)

for Breast Cancer

Sites in Iowa City +2 more locations

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06169371·Phase 4·Recruiting·Listed Dec 2023

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Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers

for Colon Cancer

Drug: Dostarlimab

Sites in Iowa City +1 more location

Sponsor: University of Iowa

Sex: All·Age: 18+

Code: NCT05239546·Phase 2·Recruiting·Listed Feb 2022

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Iowa City, Pella +178 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

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Palbociclib and Pembrolizumab in Sarcoma

for Sarcoma

1 location in Iowa City

Sponsor: John Rieth

Sex: All·Age: 12+

Code: NCT06113809·Phase 1·Recruiting·Listed Nov 2023

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Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

for Acute Biphenotypic Leukemia

Sites in Iowa City +8 more locations

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 6 Months - 26·Accepts healthy volunteers

Code: NCT03779854·Phase 2·Recruiting·Listed Dec 2018

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A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

for Hematopoietic and Lymphoid Cell Neoplasm

Sites in Iowa City +27 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 2 - 18

Code: NCT05711667·Phase 3·Recruiting·Listed Feb 2023

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Iowa City, Des Moines +143 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer

for Small Cell Lung Cancer

Drug: Monalizumab

Sites in Iowa City +3 more locations

Sponsor: Hirva Mamdani

Sex: All·Age: 18+

Code: NCT05903092·Phase 2·Recruiting·Listed Jun 2023

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Iowa City +82 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

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Quantitative MRI Assessment of Breast Cancer Therapy Response

for Breast Cancer

Sites in Iowa City +2 more locations

Sponsor: Corewell Health East

Sex: All·Age: 18+

Code: NCT05704062·Recruiting·Listed Jan 2023

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Lurbinectedin in FET-Fused Tumors

for Ewing Sarcoma

Drug: Lurbinectedin

Sites in Iowa City +5 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10+

Code: NCT05918640·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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Breast Cancer PSMA PET

for Triple Negative Breast Cancer

1 location in Iowa City

Sponsor: Ahmad Shariftabrizi

Sex: Female·Age: 18 - 90

Code: NCT06586047·EARLY_Phase 1·Recruiting·Listed Sep 2024

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Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

for Metastatic Melanoma

Drug: Dabrafenib

Sites in Iowa City +3 more locations

Sponsor: Rina Plattner

Sex: All·Age: 18+

Code: NCT04903119·Phase 1·Recruiting·Listed May 2021

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Beat Childhood Cancer Specimen Banking and Data Registry

for Pediatric Cancer

Sites in Iowa City +16 more locations

Sponsor: Giselle Sholler

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04715178·Recruiting·Listed Jan 2021

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Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

for Cutaneous Melanoma

Drug: Avutometinib

Sites in Iowa City +1 more location

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT06194929·Phase 1, Phase 2·Recruiting·Listed Jan 2024

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Sleep Apnea in Patients With MGUS and MM

for Multiple Myeloma

1 location in Iowa City

Sponsor: Michael Tomasson

Sex: All·Age: 18 - 99

Code: NCT04114084·Recruiting·Listed Oct 2019

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177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry

for Neuroendocrine Tumors

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18+

Code: NCT06395402·Phase 2·Recruiting·Listed May 2024

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Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

for Chondrosarcoma

Sites in Iowa City +3 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT04040205·Phase 2·Recruiting·Listed Jul 2019

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Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer

for Bladder Cancer

Sites in Iowa City +1 more location

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+

Code: NCT06493370·Phase 2·Recruiting·Listed Jul 2024

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Preop Laxatives in Robotic Urologic Surgery

for Prostate Cancer

1 location in Iowa City

Sponsor: Chad R. Tracy

Sex: All·Age: 30 - 100·Accepts healthy volunteers

Code: NCT05805436·Phase 4·Recruiting·Listed Apr 2023

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A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

Sites in Iowa City +22 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Recruiting·Listed Aug 2025

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A Phase I, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Immunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0120 in Participants With Multiple Myeloma (DURGA-2)

for Multiple Myeloma

Sites in Iowa City +9 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07073547·Phase 1·Recruiting·Listed Jul 2025

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Conditions in Oncology (Iowa City, IA)

Non-small cell lung cancer (NSCLC)· 14 Breast cancer· 13 Acute myeloid leukemia (AML)· 11 Solid tumor· 10 Non-Hodgkin lymphoma· 9 Multiple myeloma· 7 Hematologic malignancy· 7 Bladder cancer· 6 Leukemia (other)· 6 Myelodysplastic syndromes (MDS)· 6 Melanoma· 6 Metastatic breast cancer· 5 Ovarian cancer· 5 Diffuse large B-cell lymphoma (DLBCL)· 5 Cancer (any)· 5 Lung cancer· 4 Colorectal cancer· 4 Prostate cancer· 4 Neuroendocrine tumors· 4 Triple-negative breast cancer· 3 HER2-negative breast cancer· 3 Pancreatic cancer· 3 Endometrial cancer· 3 Cervical cancer· 3 Glioblastoma· 3 Acute lymphoblastic leukemia· 3 Myeloproliferative neoplasm· 3 Follicular lymphoma· 3 Mantle cell lymphoma· 3 Head and neck cancer· 3 Neuroblastoma· 3 Small cell lung cancer· 2 Colon cancer· 2 Gastric cancer· 2 Esophageal cancer· 2 Kidney cancer· 2 Marginal zone lymphoma· 2 Small lymphocytic lymphoma· 2 Osteosarcoma· 2 Ewing sarcoma· 2 Pediatric cancer· 2 Gastroesophageal junction cancer· 1 Liver cancer· 1 Biliary tract cancer· 1 Metastatic prostate cancer· 1 Glioma· 1 Brain metastases· 1 Chronic lymphocytic leukemia (CLL)· 1 Myelofibrosis· 1 Hodgkin lymphoma· 1 Burkitt lymphoma· 1 Sarcoma· 1 Soft tissue sarcoma· 1