Paid Clinical Trials in Iowa City, IA

As of August 2026, 554 paid clinical trials are recruiting in Iowa City, Iowa. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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510 clinical trials

Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

for Hearing Loss, Unilateral

Sites in Iowa City +5 more locations

Sponsor: Cochlear

Sex: All·Age: 5+

Code: NCT05318417·Recruiting·Listed Apr 2022

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A Multi-Country Observational Study of Safety and Effectiveness of Elfabrio® in Fabry Patients

for Fabry Disease

Sites in Iowa City +5 more locations

Sponsor: Chiesi Farmaceutici S.p.A.

Sex: All·Age: 18+

Code: NCT06663358·Recruiting·Listed Oct 2024

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Post-Market Clinical Investigation of the IotaSOFT Insertion System

for Hearing Loss, Cochlear

Sites in Iowa City +2 more locations

Sponsor: iotaMotion, Inc.

Sex: All·Age: 12+

Code: NCT06664697·Recruiting·Listed Oct 2024

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Evaluation of the Automated Integration of a Robotics and ECochG System for Use With Cochlear Implant Surgery

for Hearing Loss, Sensorineural

1 location in Iowa City

Sponsor: iotaMotion, Inc.

Sex: All·Age: 12+

Code: NCT06664710·Recruiting·Listed Oct 2024

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Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19

for Long COVID

Sites in Iowa City +2 more locations

Sponsor: MaxWell Clinic, PLC

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06311435·Recruiting·Listed Mar 2024

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Test-retest Evaluation of [18F]F-AraG PET

for Non-small Cell Lung Cancer

1 location in Iowa City

Sponsor: CellSight Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06084806·Phase 2·Recruiting·Listed Oct 2023

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Imaging Advanced NSCLC Patients Undergoing PD-1/PD-L1 Directed Therapy Using [18F]-FARAG

for Advanced Non Small Cell Lung Cancer

1 location in Iowa City

Sponsor: CellSight Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06107374·Phase 2·Recruiting·Listed Oct 2023

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Duchenne Electronic Health Record Study

for Duchenne Muscular Dystrophy (DMD)

Sites in Iowa City +9 more locations

Sponsor: The Duchenne Registry

Sex: All·Age: All ages

Code: NCT07609394·Recruiting·Listed May 2026

Apply to this trial

Tailor VHA HH Bundle for Acute Mental Health Care

for Hand Hygiene Compliance

Sites in Iowa City +3 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 90

Code: NCT07607145·Recruiting·Listed May 2026

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CHAMP Lung Cancer Screening Program

for Lung Cancer

Sites in Iowa City & Waterloo

Sponsor: Jill Kolesar

Sex: All·Age: 50 - 77

Code: NCT07572773·Recruiting·Listed May 2026

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Sirolimus Pre-conditioning on T Cell Activity and T-cell Engaging Bispecific Antibody Efficacy in Multiple Myeloma

for Multiple Myeloma

1 location in Iowa City

Sponsor: Christopher Strouse

Sex: All·Age: 18+

Code: NCT07581704·Phase 1·Recruiting·Listed May 2026

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A Study of Methylprednisolone in People Having Liver Surgery

for Hepatectomy

Sites in Iowa City +18 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07507643·Phase 3·Recruiting·Listed Apr 2026

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Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for Glioma

1 location in Iowa City

Sponsor: Kailin Yang, MD, PhD

Sex: All·Age: 18+

Code: NCT07541781·Phase 1·Recruiting·Listed Apr 2026

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Continued Pressure for Alveolar Protection (CPAP Trial)

for Bronchopulmonary Dysplasia (BPD)

Sites in Iowa City +14 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 31 Weeks

Code: NCT07417111·Recruiting·Listed Feb 2026

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Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window Trial

for Endometrial Endometrioid Adenocarcinoma

Sites in Iowa City +3 more locations

Sponsor: New Mexico Cancer Research Alliance

Sex: Female·Age: 18+

Code: NCT07436793·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

Glaucoma Related Quality of Life

for Glaucoma

1 location in Iowa City

Sponsor: Marc Toeteberg-Harms

Sex: All·Age: 18+

Code: NCT07510087·Recruiting·Listed Apr 2026

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5-Azacitidine Plus PD-1/PD-L1 Inhibitor With PD-1/PD-L1 Refractory Tumors

for Solid Tumor

1 location in Iowa City

Sponsor: Mohammed Milhem

Sex: All·Age: 18 - 99

Code: NCT07404332·Phase 1·Recruiting·Listed Feb 2026

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T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas

for Malignant Glioma

1 location in Iowa City

Sponsor: John M. Buatti

Sex: All·Age: 21+

Code: NCT07447531·Recruiting·Listed Mar 2026

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for Advanced Endometrial Carcinoma

Drug: Bevacizumab

Sites in Iowa City, Cedar Rapids +238 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07198074·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

for Ulcerative Colitis (UC)

Sites in Iowa City +10 more locations

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237516·Recruiting·Listed Nov 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Iowa City, Cedar Rapids +1098 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Iowa City, Cedar Rapids +913 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

Sites in Iowa City, Cedar Rapids +777 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

Sites in Iowa City, Cedar Rapids +630 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

Sites in Iowa City, Cedar Rapids +653 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024

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Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

for Bladder Adenocarcinoma

Drug: Cabozantinib

Sites in Iowa City, Bettendorf +221 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03866382·Phase 2·Recruiting·Listed Mar 2019

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

Sites in Iowa City, Cedar Rapids +303 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025

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Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC

for Bladder Cancer

1 location in Iowa City

Sponsor: Michael A. O'Donnell

Sex: All·Age: 18 - 99

Code: NCT07322263·Phase 2·Recruiting·Listed Jan 2026

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Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

for B Acute Lymphoblastic Leukemia

Sites in Iowa City +154 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18 - 39

Code: NCT03150693·Phase 3·Recruiting·Listed May 2017

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Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for Clear Cell Renal Cell Carcinoma

Sites in Iowa City, Cedar Rapids +406 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06661720·Phase 3·Recruiting·Listed Oct 2024

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Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

for Muscle Invasive Bladder Urothelial Carcinoma

Sites in Iowa City, Marshalltown +445 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05987241·Phase 2, Phase 3·Recruiting·Listed Aug 2023

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Iowa City, Council Bluffs +479 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

Sites in Iowa City, Cedar Rapids +372 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

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Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for Childhood Extracranial Germ Cell Tumor

Sites in Iowa City, Ankeny +385 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017

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Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

for Refractory Differentiated Thyroid Gland Carcinoma

Sites in Iowa City, Cedar Rapids +284 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06475989·Phase 3·Recruiting·Listed Jun 2024

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Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Sites in Iowa City, Marshalltown +228 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 60+

Code: NCT05976763·Phase 3·Recruiting·Listed Aug 2023

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Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

for Bladder Cancer

Sites in Iowa City +5 more locations

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07225127·Recruiting·Listed Nov 2025

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MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

Sites in Iowa City, Pella +327 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

Sites in Iowa City, Ankeny +375 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023

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Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

for Smoldering Plasma Cell Myeloma

Drug: Daratumumab

Sites in Iowa City, Bettendorf +486 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT03937635·Phase 3·Recruiting·Listed May 2019

Apply to this trial