Clinical Trials at City of Hope at Irvine Lennar

As of August 2026, 55 paid clinical trials are recruiting at City of Hope at Irvine Lennar in Irvine, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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56 clinical trials at City of Hope at Irvine Lennar

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Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

for Chronic Lymphocytic Leukemia

Drug: Epcoritamab

Sites in Irvine, Long Beach +5 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07218510·Phase 2·Recruiting·Listed Oct 2025

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Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

for Prostate Adenocarcinoma

Sites in Irvine, Duarte +130 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT05806515·Phase 2·Recruiting·Listed Apr 2023

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Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

for Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06249282·Phase 1·Recruiting·Listed Feb 2024

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Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

Sites in Irvine, Upland +14 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

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Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Sites in Irvine, Duarte +6 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 54

Code: NCT06918431·Phase 2·Recruiting·Listed Apr 2025

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Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Nemtabrutinib

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06572618·Phase 2·Recruiting·Listed Aug 2024

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Different Types of Massage Therapy to Reduce Anxiety During Chemotherapy Infusion in Patients With Cancer

for Hematopoietic and Lymphatic System Neoplasm

1 location in Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07184294·Recruiting·Listed Sep 2025

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Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

for Breast Carcinoma

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06731894·Phase 2·Recruiting·Listed Dec 2024

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Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06910761·Phase 2·Recruiting·Listed Apr 2025

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Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

for Metastatic Pancreatic Adenocarcinoma

Sites in Irvine, Newport Beach +20 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06524973·Recruiting·Listed Jul 2024

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Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Irvine, Upland +5 more locations

Sponsor: City of Hope Medical Center

Sex: Female·Age: 40+

Code: NCT06954831·Phase 2·Recruiting·Listed May 2025

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Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06260033·Phase 2·Recruiting·Listed Feb 2024

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Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Irvine, Long Beach +4 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 70+

Code: NCT04305834·Phase 2·Recruiting·Listed Mar 2020

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Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

for Endometrial Carcinoma

Sites in Irvine, Orange +329 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05256225·Phase 3·Recruiting·Listed Feb 2022

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Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

for Metastatic Malignant Solid Neoplasm

Sites in Irvine, Orange +16 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05372614·Phase 1·Recruiting·Listed May 2022

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