Paid Clinical Trials in Irvine, CA

As of September 2026, 388 paid clinical trials are recruiting in Irvine, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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355 clinical trials

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A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease

for Alzheimer's Disease

Drug: Trontinemab

Sites in Irvine, Santa Ana +2 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 55 - 80

Code: NCT07717411·Phase 3·Recruiting·Listed Jul 2026

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Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-2)

for ADHD

Drug: Solriamfetol

Sites in Irvine, Orange +21 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 6 - 11

Code: NCT07717879·Phase 3·Recruiting·Listed Jul 2026

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Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-3)

for ADHD

Drug: Solriamfetol

Sites in Irvine, Long Beach +22 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 12 - 17

Code: NCT07717892·Phase 3·Recruiting·Listed Jul 2026

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Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

for Lung Cancer Screening

Sites in Irvine, Tustin +55 more locations

Sponsor: University of California, Irvine

Sex: All·Age: 50 - 80

Code: NCT07711691·Recruiting·Listed Jul 2026

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A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine

for Acute Migraine

Drug: Elismetrep

Sites in Irvine, Mission Viejo +111 more locations

Sponsor: Kallyope Inc.

Sex: All·Age: 18+

Code: NCT07674654·Phase 3·Recruiting·Listed Jun 2026

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AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

for Metastatic Castration-resistant Prostate Cancer

Sites in Irvine, Newport Beach +23 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT07611110·Phase 3·Recruiting·Listed May 2026

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A Study of LY3439539 in Participants With Alzheimer's Disease

for Alzheimer Disease

Sites in Irvine, Long Beach +2 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 50 - 85

Code: NCT07598370·Phase 1·Recruiting·Listed May 2026

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A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

Sites in Irvine, Duarte +2 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07586202·Phase 2·Recruiting·Listed May 2026

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A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

for Lupus Nephritis

Sites in Irvine, Fullerton +10 more locations

Sponsor: Fate Therapeutics

Sex: All·Age: 12 - 70

Code: NCT07570862·Phase 2·Recruiting·Listed May 2026

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Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma

for Glioblastoma, IDH-Wildtype

Sites in Irvine, Orange +52 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07452458·Phase 3·Recruiting·Listed Mar 2026

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Irvine, Orange +78 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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Ceribell Delirium Monitor Outcomes Pilot Study

for Delirium in the Intensive Care Unit

Sites in Irvine +1 more location

Sponsor: Ceribell Inc.

Sex: All·Age: 18+

Code: NCT07449416·Recruiting·Listed Mar 2026

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A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer

for Small Cell Lung Cancer

Sites in Irvine, Duarte +35 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07365241·Phase 3·Recruiting·Listed Jan 2026

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

Sites in Irvine, Duarte +46 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting·Listed Dec 2025

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Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting

for Hematopoietic and Lymphatic System Neoplasm

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07126301·Recruiting·Listed Aug 2025

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A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

for Parkinson Disease

Sites in Irvine, Los Angeles +20 more locations

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 40 - 80

Code: NCT06976268·Phase 2, Phase 3·Recruiting·Listed May 2025

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Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

for Metastatic Colorectal Adenocarcinoma

Sites in Irvine, Costa Mesa +8 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06102902·Phase 1·Recruiting·Listed Oct 2023

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A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata

for Alopecia Areata

Drug: Ritlecitinib

Sites in Irvine, Brea +20 more locations

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06873945·Phase 3·Recruiting·Listed Mar 2025

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Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH)

for Hemophagocytic Lymphohistiocytoses

Drug: Ruxolitinib

Sites in Irvine, San Diego +2 more locations

Sponsor: Jerry Lee, MD, MSc, MPhil

Sex: All·Age: 18+

Code: NCT06160791·Phase 2·Recruiting·Listed Dec 2023

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Comparing the Radiopharmaceutical Drug, [177Lu]Lu-DOTATATE, to Standard of Care Treatment for Patients With Meningioma That Has Come Back After Prior Treatment

for Intracranial Meningioma

Sites in Irvine, La Jolla +14 more locations

Sponsor: RTOG Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06955169·Phase 2·Recruiting·Listed May 2025

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Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

for Endometrial Carcinoma

Sites in Irvine, Orange +325 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05256225·Phase 3·Recruiting·Listed Feb 2022

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

Sites in Irvine, Duarte +45 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting·Listed May 2025

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Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

for Metastatic Malignant Solid Neoplasm

Sites in Irvine, Orange +16 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05372614·Phase 1·Recruiting·Listed May 2022

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A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

for Accelerated Phase Myeloproliferative Neoplasm

Drug: Iadademstat

Sites in Irvine, Orange +29 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06661915·Phase 2·Recruiting·Listed Oct 2024

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ctDNA-Guided Therapy for Relapsed/Refractory Hodgkin Lymphoma

for Hodgkin Lymphoma, Adult

Sites in Irvine, Los Angeles +4 more locations

Sponsor: Michael Spinner, MD

Sex: All·Age: 18+

Code: NCT07021989·Phase 2·Recruiting·Listed Jun 2025

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Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

for Ovarian Cancer

Sites in Irvine, Duarte +8 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT05797168·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

for Multiple Myeloma

Sites in Irvine, Duarte +6 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06106945·Phase 1, Phase 2·Recruiting·Listed Oct 2023

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Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

for Metastatic Clear Cell Renal Cell Carcinoma

Drug: Cabozantinib

Sites in Irvine, Duarte +44 more locations

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07011719·Phase 3·Recruiting·Listed Jun 2025

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Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: IMVT-1402

Sites in Irvine, Los Angeles +46 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 80

Code: NCT07039916·Phase 3·Recruiting·Listed Jun 2025

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Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia

for Insomnia Disorder

Sites in Irvine +19 more locations

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 2 - 17

Code: NCT06953869·Phase 3·Recruiting·Listed May 2025

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A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

for Myelodysplastic Syndromes

Sites in Irvine, Duarte +4 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06847867·Phase 2·Recruiting·Listed Feb 2025

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A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

for Polymyositis, Dermatomyositis

Sites in Irvine +33 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT06455449·Phase 3·Recruiting·Listed Jun 2024

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Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

for Acute Respiratory Distress Syndrome

Sites in Irvine, Sacramento +30 more locations

Sponsor: Direct Biologics, LLC

Sex: All·Age: 18 - 75

Code: NCT05354141·Phase 3·Recruiting·Listed Apr 2022

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