Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

Part of paid clinical trials in Anaheim, California.

Sponsor: University of California, Irvine
Study ID: NCT07711691
Status: Not Yet Recruiting

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Conditions

Early Detection of Cancer
Lung Cancer Screening
Lung Neoplasms
Smoking ( Cigarette)

Eligibility Criteria

Sex: ALL
Age: 50 Years - 80 Years
Healthy Volunteers: Not accepted

Interventions

Empower LCS — BEHAVIORAL
Empower LCS consists of (1) a lung cancer screening decision aid, (2) primary care provider notification of patients' eligibility for lung cancer screening, (3) patient text reminders to discuss lung cancer screening with their primary care provider, and (4) tailored support materials including financial education and national/local resources for patients who screen positive for health-related social needs.
Call+ Telephone Navigation — BEHAVIORAL
Participants who do not complete lung cancer screening by approximately 4 months after randomization will receive the Call+, a telephone-based navigation intervention delivered by a lay navigator to identify and address barriers to screening, facilitate scheduling, and connect participants with available resources.
Usual Care — OTHER
Usual care
Education — OTHER
One-page educational material about benefits and risks of lung cancer screening

Study Details

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce the risk of dying from lung cancer, but many people who are eligible for screening do not receive it. The purpose of the Empower LCS/Call+ study is to evaluate new strategies to improve lung cancer screening among adults who are eligible for screening based on current U.S. Preventive Services Task Force (USPSTF) guidelines. This pilot randomized controlled trial will enroll approximately 80 participants from UC Irvine Health and Emory Healthcare. Participants will be randomly assigned to receive either enhanced usual care or the Empower LCS/Call+ intervention. The intervention includes educational materials, reminders for patients and primary care providers, and information about financial and community resources when appropriate. Participants who do not complete lung cancer screening after the initial intervention may receive additional telephone-based navigation through the Call+ program to help identify and address barriers to screening and help with scheduling. Participants will complete a baseline survey and follow-up surveys at 4 and 8 months, and researchers will review electronic health record information to determine whether lung cancer screening was discussed, ordered, and completed. Some participants will also be invited to complete a one-time interview about their experiences with the study. The results of this study will help determine the feasibility, acceptability, and preliminary effectiveness of the Empower LCS/Call+ intervention and will inform future efforts to improve equitable access to lung cancer screening.

Key Dates

First listed: Jul 17, 2026
Start date: Sep 1, 2026
Status verified: Jul 2026
Primary completion: Aug 31, 2028
Completion: Dec 31, 2028

Study Design

Enrollment: 80 participants (estimated)
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Arms

Active Comparator: Enhanced Usual Care
Usual care + educational brochure
Experimental: Empower LCS/Call+
Empower LCS with Call+ offered to non-responders

Primary Outcome Measure

Completion of lung cancer screening with low-dose computed tomography (LDCT) [ Time Frame: 4 months after randomization ]

Central Contacts

Gelareh Sadigh, MD
(714) 456-3610
[email protected]

Locations (57)

Facility	City	State	ZIP	Site coordinators
UCI Health Family Health Center - Anaheim	Anaheim	California	92801	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health - Costa Mesa	Costa Mesa	California	92627	Gelareh Sadigh, MD [email protected] (714) 456-3610
CHAO Family Comprehensive Cancer Center- Irvine	Irvine	California	92612	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health Gottschalk Medical Plaza	Irvine	California	92697	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health - Laguna Hills	Laguna Hills	California	92653	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health - Newport Beach MacArthur	Newport Beach	California	92660	Gelareh Sadigh, MD [email protected] (714) 456-3610
Primary Care & Internal Medicine Services	Orange	California	92868	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Chao Family Comprehensive Cancer Center	Orange	California	92868	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health SeniorHealth Center -Pavillion 4	Orange	California	92868	-
UCI Medical Center, Pavilion 3	Orange	California	92868	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health Family Health Center - Santa Ana	Santa Ana	California	92701	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health - Tustin	Tustin	California	92670	Gelareh Sadigh, MD [email protected] (714) 456-3610
UCI Health - Yorba Linda	Yorba Linda	California	92886	Gelareh Sadigh, MD [email protected] (714) 456-3610
Emory at Avalon - Primary Care	Alpharetta	Georgia	30009	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Northlake - Primary Care	Atlanta	Georgia	30345	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Peachtree Hills - Primary Care	Atlanta	Georgia	30309	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Toco Hills - Primary Care	Atlanta	Georgia	30329	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic at 1365 Clifton Road - Primary Care	Atlanta	Georgia	30322	Ilana Graetz, PhD [email protected] 404-7271483
Emory Clinic at 1525 Clifton Road - Primary Care	Atlanta	Georgia	30322	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic at Midtown	Atlanta	Georgia	30308	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic at Old Fourth Ward	Atlanta	Georgia	30047	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Gastroenterology	Atlanta	Georgia	30342	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Buford - Primary Care	Buford	Georgia	30519	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Decatur - Primary Care	Decatur	Georgia	30033	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Decatur - Primary Care (Irvin Court)	Decatur	Georgia	30030	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Decatur - Primary Care (Scott Boulevard)	Decatur	Georgia	30030	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Flat Shoals - Primary Care	Decatur	Georgia	30034	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Oak Grove - Primary Care	Decatur	Georgia	30033	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic at Decatur - Primary Care	Decatur	Georgia	30033	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic Downtown Decatur	Decatur	Georgia	30030	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Duluth	Duluth	Georgia	30096	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Sugarloaf - Primary Care	Duluth	Georgia	30097	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Dunwoody	Dunwoody	Georgia	30338	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic at Saint Joseph's	Dunwoody	Georgia	30342	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Findley Road	Johns Creek	Georgia	30097	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Spivey Station - Primary Care	Jonesboro	Georgia	30236	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at LaGrange - Davis Road	La Grange	Georgia	30241	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at LaGrange - Smith Street - Primary Care	La Grange	Georgia	30240	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Beaver Ruin - Primary Care	Lilburn	Georgia	30047	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Mountain Park - Primary Care	Lilburn	Georgia	30047	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Hillandale Family Medicine	Lithonia	Georgia	30058	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Miller Grove - Primary Care	Lithonia	Georgia	30058	Ilana Graetz, PhD [email protected] 404-727-1483
Emory Clinic at Lithonia - Primary Care	Lithonia	Georgia	30058	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at East Cobb - Primary Care	Marietta	Georgia	30068	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Peachtree City - Primary Care	Peachtree City	Georgia	30269	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Sharpsburg	Sharpsburg	Georgia	30277	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Belmont - Primary Care	Smyrna	Georgia	30080	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Centerville - Primary Care	Snellville	Georgia	30339	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Snellville - Primary Care (Lenora Church Road)	Snellville	Georgia	30078	il Graetz, PhD [email protected] 404-727-1483
Emory at Snellville - Primary Care (Oak Road)	Snellville	Georgia	30078	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Snellville Primary Care (Presidential Circle)	Snellville	Georgia	30078	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Eagles Landing Primary Care	Stockbridge	Georgia	30281	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Rockbridge Primary Care & Nephrology	Stone Mountain	Georgia	30087	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Stone Mountain - Primary Care	Stone Mountain	Georgia	30083	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at Tucker - Primary Care (1459 Montreal Road)	Tucker	Georgia	30084	Ilana Graetz, PhD [email protected] 404-727-1483
Pavilion Family Medicine Center	Warner Robins	Georgia	31093	Ilana Graetz, PhD [email protected] 404-727-1483
Emory at West Point	West Point	Georgia	31833	Ilana Graetz, PhD [email protected] 404-727-1483

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