Clinical Trials at Mayo Clinic

As of August 2026, 71 paid clinical trials are recruiting at Mayo Clinic, located at 4500 SAN PABLO RD S, JACKSONVILLE, FL 32224-1865, phone (904) 953-7330 in Jacksonville, Florida. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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72 clinical trials at Mayo Clinic

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Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only

for Ankle Rheumatoid Arthritis

Sites in Jacksonville +1 more location

Sponsor: Exactech

Sex: All·Age: 21+

Code: NCT05619588·Recruiting·Listed Nov 2022

Apply to this trial

Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL

for CLL/SLL

Sites in Jacksonville +6 more locations

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 85

Code: NCT04215809·Phase 1·Recruiting·Listed Jan 2020

Apply to this trial

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

for Advanced Cancer

Sites in Jacksonville +6 more locations

Sponsor: Qurient Co., Ltd.

Sex: All·Age: 18+

Code: NCT05394103·Phase 1, Phase 2·Recruiting·Listed May 2022

Apply to this trial

APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies

for Hematologic Malignancies

Sites in Jacksonville +1 more location

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18+

Code: NCT03537482·EARLY_Phase 1·Recruiting·Listed May 2018

Apply to this trial

Study of Pembrolizumab Treatment After CYAD-101 With FOLFOX Preconditioning in Metastatic Colorectal Cancer

for Unresectable Metastatic Colorectal Cancer

Sites in Jacksonville & Tampa

Sponsor: Celyad Oncology SA

Sex: All·Age: 18+

Code: NCT04991948·Phase 1·Recruiting·Listed Aug 2021

Apply to this trial

Erector Spinae Plane Block Versus Trigger Point Injection for Chronic Thoracic Myofascial Pain

for Back Pain

Sites in Jacksonville +4 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT07632820·Phase 4·Recruiting·Listed Jun 2026

Apply to this trial

Prospective Evaluation of Physician Modified Endografts for Aortic Disease

for Aortic Aneurysm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 50+

Code: NCT07611968·Recruiting·Listed May 2026

Apply to this trial

Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

for Depression Disorder

1 location in Jacksonville

Sponsor: Hospital Italiano de Buenos Aires

Sex: All·Age: 18 - 99

Code: NCT07639359·Phase 2·Recruiting·Listed Jun 2026

Apply to this trial

Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas

for Pituitary Adenoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT07456878·Phase 1·Recruiting·Listed Mar 2026

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Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

for Intracerebral Hemorrhage

Sites in Jacksonville, Gainesville +47 more locations

Sponsor: Joseph Broderick, MD

Sex: All·Age: 18 - 80

Code: NCT07227246·Phase 3·Recruiting·Listed Nov 2025

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Comparison of Iliac Crest Marrow vs. Proximal Tibia Avitus® Bone Graft

for Bone Graft

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT07434505·Recruiting·Listed Feb 2026

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The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

Sites in Jacksonville, Gainesville +85 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting·Listed May 2023

Apply to this trial

PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Jacksonville +30 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting·Listed Sep 2024

Apply to this trial

ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Jacksonville, Davie +34 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

Apply to this trial

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

for Chondrosarcoma

Sites in Jacksonville +3 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT04040205·Phase 2·Recruiting·Listed Jul 2019

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Jacksonville, Tampa +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

for Endometrial Cancer

Sites in Jacksonville, Orlando +18 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05051722·Recruiting·Listed Sep 2021

Apply to this trial

Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

for Lung Transplant

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05426200·Recruiting·Listed Jun 2022

Apply to this trial

Reduced Immunosuppression in Older Renal Transplant Recipients With Trugraf®/TRAC Monitoring (RIOT Trial): A Prospective, Randomized, Multicenter Trial.

for Kidney Transplantation

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06568549·Phase 4·Recruiting·Listed Aug 2024

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Neurostimulation for Treatment of Chronic Upper Limb Pain After Brachial Plexus Injury

for Brachial Plexus Injury

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04733599·Recruiting·Listed Feb 2021

Apply to this trial

Safety and Tolerability of Vertebral Bone Marrow-derived Mesenchymal Stem Cells (BM-MSC) in Real World Scenarios of Patients With Chronic Kidney Disease (CKD)

for Chronic Kidney Diseases

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06752577·Recruiting·Listed Dec 2024

Apply to this trial

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

Sites in Jacksonville +9 more locations

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting·Listed Nov 2021

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Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

for IBS - Irritable Bowel Syndrome

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06684470·EARLY_Phase 1·Recruiting·Listed Nov 2024

Apply to this trial

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease

for Alzheimer Disease

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT03821857·Phase 4·Recruiting·Listed Jan 2019

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The REgistry of Very Early Estrogen and AnovuLation

for Hypothalamic Amenorrhea, Functional

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 40

Code: NCT06583408·Recruiting·Listed Sep 2024

Apply to this trial

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Jacksonville, Miami +26 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

Apply to this trial

Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits

for Proliferative Glomerulonephritis With Monoclonal IgG Deposits

Drug: Daratumumab

Sites in Jacksonville +3 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05654506·Phase 2·Recruiting·Listed Dec 2022

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Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery

for Epilepsy

1 location in Jacksonville

Sponsor: Sanjeet S. Grewal

Sex: All·Age: 18 - 75

Code: NCT06280092·EARLY_Phase 1·Recruiting·Listed Feb 2024

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REtroperitoneal SArcoma Registry: an International Prospective Initiative

for Retroperitoneal Sarcoma

Sites in Jacksonville, Tampa +4 more locations

Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Sex: All·Age: 18+

Code: NCT03838718·Recruiting·Listed Feb 2019

Apply to this trial

A Study of APG-3288 in Relapsed/Refractory Blood Cancers

for Relapsed/Refractory Hematological Malignancies

Sites in Jacksonville +4 more locations

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18+

Code: NCT07424833·Phase 1·Recruiting·Listed Feb 2026

Apply to this trial

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

for Breast Cancer

Sites in Jacksonville +11 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05307705·Phase 1·Recruiting·Listed Apr 2022

Apply to this trial