Oncology Clinical Trials in La Jolla, CA

As of July 2026, 124 paid clinical trials are recruiting for Oncology in La Jolla, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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125 clinical trials for Oncology

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A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndromes

Sites in La Jolla, Duarte +21 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06499285·Phase 3·Recruiting·Listed Jul 2024

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Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

for Hematologic Malignancies

Drug: Nemtabrutinib

Sites in La Jolla +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04728893·Phase 2·Recruiting·Listed Jan 2021

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Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in La Jolla, Santa Monica +20 more locations

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06343402·Phase 1·Recruiting·Listed Apr 2024

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A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

for Multiple Myeloma

Drug: Linvoseltamab

Sites in La Jolla +12 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05137054·Phase 1·Recruiting·Listed Nov 2021

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Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

for Relapsed Multiple Myeloma

Sites in La Jolla, Stanford +10 more locations

Sponsor: Opna Bio LLC

Sex: All·Age: 18+

Code: NCT06433947·Phase 1·Recruiting·Listed May 2024

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A Study of YL201 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in La Jolla, Fair Oaks +17 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT05434234·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

Sites in La Jolla, San Francisco +10 more locations

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

for Hepatocellular Carcinoma

Sites in La Jolla, Beverly Hills +10 more locations

Sponsor: Replimune, Inc.

Sex: All·Age: 18+

Code: NCT05733598·Phase 2·Recruiting·Listed Feb 2023

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Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Livmoniplimab

Sites in La Jolla +16 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06236438·Phase 2, Phase 3·Recruiting·Listed Feb 2024

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Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

for Endometrial Cancer

Sites in La Jolla, San Francisco +16 more locations

Sponsor: Faeth Therapeutics

Sex: Female·Age: 18+

Code: NCT06463028·Phase 2·Recruiting·Listed Jun 2024

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A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

for Renal Cell Carcinoma

Sites in La Jolla, Los Angeles +18 more locations

Sponsor: HiberCell, Inc.

Sex: All·Age: 18+

Code: NCT06234605·Phase 1·Recruiting·Listed Jan 2024

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Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in La Jolla, Palo Alto +7 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05007782·Phase 1·Recruiting·Listed Aug 2021

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A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer

Sites in La Jolla, Los Angeles +10 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06644768·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

for Head and Neck Squamous Cell Carcinoma

Sites in La Jolla, Los Angeles +13 more locations

Sponsor: Bicara Therapeutics

Sex: All·Age: 18+

Code: NCT04429542·Phase 1·Recruiting·Listed Jun 2020

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First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.

for Solid Tumor

Sites in La Jolla, Los Angeles +18 more locations

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06603844·Phase 1, Phase 2·Recruiting·Listed Sep 2024

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A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

for Solid Tumor, Adult

Sites in La Jolla, Los Angeles +8 more locations

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06682793·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in La Jolla +13 more locations

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting·Listed Feb 2024

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A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

Sites in La Jolla, San Diego +20 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting·Listed May 2018

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A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)

for Metastatic Castration-resistant Prostate Cancer

Sites in La Jolla +8 more locations

Sponsor: Daiichi Sankyo

Sex: Male·Age: 18+

Code: NCT07244341·Phase 1·Recruiting·Listed Nov 2025

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A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

for Solid Tumors

Sites in La Jolla, Duarte +6 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07195916·Phase 1·Recruiting·Listed Sep 2025

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FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

for Non-Small Cell Lung Cancer

Sites in La Jolla +4 more locations

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT07216105·Phase 1·Recruiting·Listed Oct 2025

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A Study of LY4170156 in Participants With Selected Advanced Solid Tumors

for Ovarian Neoplasms

Sites in La Jolla +8 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06400472·Phase 1·Recruiting·Listed May 2024

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SW-682 in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in La Jolla, Los Angeles +6 more locations

Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Sex: All·Age: 18+

Code: NCT06251310·Phase 1·Recruiting·Listed Feb 2024

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A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC

for Non-small Cell Lung Cancer

Sites in La Jolla +5 more locations

Sponsor: Teligene US

Sex: All·Age: 18+

Code: NCT06010329·Phase 2·Recruiting·Listed Aug 2023

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FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

for Breast Cancer

Sites in La Jolla, Los Angeles +5 more locations

Sponsor: Regor Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05304962·Phase 1·Recruiting·Listed Mar 2022

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A Study Evaluating OBI-902 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in La Jolla +2 more locations

Sponsor: OBI Pharma, Inc

Sex: All·Age: 18+

Code: NCT07124117·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

Sites in La Jolla, Duarte +4 more locations

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting·Listed Apr 2025

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A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

for Melanoma

1 location in La Jolla

Sponsor: Replimune, Inc.

Sex: All·Age: 18+

Code: NCT06887348·Recruiting·Listed Mar 2025

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Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

for Solid Tumor, Adult

Sites in La Jolla, Stanford +1 more location

Sponsor: BioEclipse Therapeutics

Sex: All·Age: 18+

Code: NCT04282044·Phase 1·Recruiting·Listed Feb 2020

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

Sites in La Jolla, Duarte +4 more locations

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting·Listed Sep 2018

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in La Jolla, San Diego +638 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

Sites in La Jolla, San Diego +428 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022

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Artificial Intelligence and Machine Learning to Guide CDK4/6 Inhibitor Rechallenge in Breast Cancer.

for Breast Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07227233·Phase 2·Recruiting·Listed Nov 2025

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Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

for Biochemically Recurrent Prostate Carcinoma

Drug: Apalutamide

Sites in La Jolla, San Diego +276 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: Male·Age: 18+

Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020

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Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

for Lung Non-Small Cell Carcinoma

Sites in La Jolla, Loma Linda +261 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06498635·Phase 3·Recruiting·Listed Jul 2024

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Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

Sites in La Jolla, San Diego +278 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022

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Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in La Jolla, San Diego +144 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06532279·Phase 2·Recruiting·Listed Aug 2024

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Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

for Malignant Female Reproductive System Neoplasm

Sites in La Jolla, San Diego +175 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06126276·Phase 2·Recruiting·Listed Nov 2023

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in La Jolla, San Diego +255 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in La Jolla, San Diego +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Conditions in Oncology (La Jolla, CA)

Solid tumor· 28 Non-small cell lung cancer (NSCLC)· 26 Breast cancer· 17 Colorectal cancer· 13 Prostate cancer· 12 Ovarian cancer· 10 Cancer (any)· 9 Pancreatic cancer· 8 Kidney cancer· 8 Head and neck cancer· 8 Non-Hodgkin lymphoma· 7 Endometrial cancer· 6 Hematologic malignancy· 6 Triple-negative breast cancer· 5 Metastatic breast cancer· 4 Lung cancer· 4 Gastric cancer· 4 Liver cancer· 4 Melanoma· 4 HER2-positive breast cancer· 3 Biliary tract cancer· 3 Cervical cancer· 3 Multiple myeloma· 3 Chronic lymphocytic leukemia (CLL)· 3 Small lymphocytic lymphoma· 3 Mesothelioma· 3 HER2-negative breast cancer· 2 Colon cancer· 2 Rectal cancer· 2 Esophageal cancer· 2 Gastroesophageal junction cancer· 2 Metastatic prostate cancer· 2 Fallopian tube cancer· 2 Glioblastoma· 2 Myelodysplastic syndromes (MDS)· 2 Myelofibrosis· 2 Follicular lymphoma· 2 Mantle cell lymphoma· 2 Marginal zone lymphoma· 2 Neuroendocrine tumors· 2 Small cell lung cancer· 1 Gastrointestinal cancer· 1 Bladder cancer· 1 Glioma· 1 Brain cancer· 1 Acute myeloid leukemia (AML)· 1 Leukemia (other)· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Diffuse large B-cell lymphoma (DLBCL)· 1 Osteosarcoma· 1