Oncology Clinical Trials in La Jolla, CA

As of July 2026, 124 paid clinical trials are recruiting for Oncology in La Jolla, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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125 clinical trials for Oncology

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SB-4826 in Adult Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphomas

for Non Hodgkin Lymphoma

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07222631·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

for Lung Non-Small Cell Carcinoma

Sites in La Jolla, Rancho Mirage +241 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06116682·Phase 2·Recruiting·Listed Nov 2023

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

Sites in La Jolla, Orange +26 more locations

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting·Listed May 2019

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Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in La Jolla, San Diego +56 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500481·Phase 3·Recruiting·Listed Jul 2024

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

Sites in La Jolla, San Diego +643 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024

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Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

for Metastatic Malignant Solid Neoplasm

Sites in La Jolla, San Diego +16 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687110·Phase 1·Recruiting·Listed Jan 2023

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Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

for Advanced Malignant Solid Neoplasm

Sites in La Jolla, San Diego +21 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05327010·Phase 2·Recruiting·Listed Apr 2022

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in La Jolla, Newport Beach +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

for Anatomic Stage I Breast Cancer AJCC v8

Sites in La Jolla, Riverside & Duarte

Sponsor: City of Hope Medical Center

Sex: Female·Age: 18+

Code: NCT06763328·Phase 3·Recruiting·Listed Jan 2025

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in La Jolla, San Diego +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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TERPS Trial for de Novo Oligometastic Prostate Cancer

for Prostate Cancer

Sites in La Jolla +9 more locations

Sponsor: University of Maryland, Baltimore

Sex: Male·Age: 18+

Code: NCT05223803·Phase 2·Recruiting·Listed Feb 2022

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

Sites in La Jolla, Newport Beach +41 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

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Intra-tumoral Mitazalimab (CD40 Antibody) With Irreversible Electroporation (IRE) in Locally Advanced Pancreas Cancer

for Pancreatic Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT06205849·Phase 1·Recruiting·Listed Jan 2024

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Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC

for Advanced Renal Cell Carcinoma

Sites in La Jolla +3 more locations

Sponsor: Karie Runcie

Sex: All·Age: 18+

Code: NCT06863311·Phase 2·Recruiting·Listed Mar 2025

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

Sites in La Jolla +3 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting·Listed Apr 2020

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in La Jolla, San Diego +178 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

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Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers

for Anal Carcinoma

Sites in La Jolla, San Francisco +6 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05663502·Recruiting·Listed Dec 2022

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Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

for Clinical Stage III Cutaneous Melanoma AJCC v8

Sites in La Jolla, Los Angeles +23 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05896839·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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Retifanlimab and Ruxolitinib In Solid Malignancies

for Non Small Cell Lung Carcinoma

Drug: Retifanlimab

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: All ages

Code: NCT07219576·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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Study of Personalized Cancer Therapy to Determine Response and Toxicity

for Cancer

Sites in La Jolla, San Diego & Rancho Mirage

Sponsor: Shu Mei Kato

Sex: All·Age: 7+

Code: NCT02478931·Recruiting·Listed Jun 2015

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Efficacy of OneMark Device in Identifying Breast Cancer for Surgery and Surveillance

for Breast Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07087691·Recruiting·Listed Jul 2025

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Image-guided, Tumor-focused Radiotherapy Treatment in Intermediate and High-risk Prostate Cancer

for Prostate Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: Male·Age: 18+

Code: NCT06990542·Phase 2·Recruiting·Listed May 2025

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Elranatamab in Relapsed/Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Elranatamab

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT06711705·Phase 2·Recruiting·Listed Dec 2024

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ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services

for HIV

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: Female·Age: 25 - 64

Code: NCT06128304·Recruiting·Listed Nov 2023

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Precision-Based Genomics in Prostate Cancer

for Prostate Cancer

Sites in La Jolla, San Francisco +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT04706663·Recruiting·Listed Jan 2021

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Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy

for Cervical Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: Female·Age: 18+

Code: NCT07121543·Recruiting·Listed Aug 2025

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Evaluation of a Telehealth Oncofertility Care Intervention in Adolescent and Young Adult Cancer Patients

for Cancer

Sites in La Jolla, San Diego & Duarte

Sponsor: University of California, San Diego

Sex: All·Age: 0 - 50

Code: NCT05443737·Phase 3·Recruiting·Listed Jul 2022

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A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

for Cervical Cancer

Sites in La Jolla, San Diego +124 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT04831580·Recruiting·Listed Apr 2021

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Prostate Cancer IMAGing IN Early Detection (IMAGINED Trial)

for Prostate Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: Male·Age: All ages

Code: NCT05882253·Recruiting·Listed May 2023

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Focal Therapy for Localized Prostate Cancer

for Prostate Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT06270043·Recruiting·Listed Feb 2024

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TNBC Gut Microbiota During Neoadjuvant Treatment

for Breast Cancer

1 location in La Jolla

Sponsor: Scripps Health

Sex: All·Age: 18 - 100

Code: NCT06610097·Recruiting·Listed Sep 2024

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Prostate Assessment with Restriction Spectrum Imaging (RSI) MRI

for Prostate Cancer

1 location in La Jolla

Sponsor: University of California, San Diego

Sex: Male·Age: 18+

Code: NCT04992728·Recruiting·Listed Aug 2021

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in La Jolla, Orange +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

Sites in La Jolla, San Diego +46 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting·Listed Dec 2025

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

for Endometrial Cancer

Sites in La Jolla, Orange +64 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07044336·Phase 3·Recruiting·Listed Jun 2025

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

Sites in La Jolla, Irvine +43 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting·Listed May 2025

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A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

for Prostate Cancer

Drug: Saruparib

Sites in La Jolla, San Diego +36 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT06952803·Phase 3·Recruiting·Listed May 2025

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in La Jolla, Fullerton +29 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting·Listed Jun 2024

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A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

Sites in La Jolla, Orange +59 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06496178·Phase 3·Recruiting·Listed Jul 2024

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

Sites in La Jolla, Los Alamitos +43 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting·Listed Jan 2025

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Conditions in Oncology (La Jolla, CA)

Solid tumor· 28 Non-small cell lung cancer (NSCLC)· 26 Breast cancer· 17 Colorectal cancer· 13 Prostate cancer· 12 Ovarian cancer· 10 Cancer (any)· 9 Pancreatic cancer· 8 Kidney cancer· 8 Head and neck cancer· 8 Non-Hodgkin lymphoma· 7 Endometrial cancer· 6 Hematologic malignancy· 6 Triple-negative breast cancer· 5 Metastatic breast cancer· 4 Lung cancer· 4 Gastric cancer· 4 Liver cancer· 4 Melanoma· 4 HER2-positive breast cancer· 3 Biliary tract cancer· 3 Cervical cancer· 3 Multiple myeloma· 3 Chronic lymphocytic leukemia (CLL)· 3 Small lymphocytic lymphoma· 3 Mesothelioma· 3 HER2-negative breast cancer· 2 Colon cancer· 2 Rectal cancer· 2 Esophageal cancer· 2 Gastroesophageal junction cancer· 2 Metastatic prostate cancer· 2 Fallopian tube cancer· 2 Glioblastoma· 2 Myelodysplastic syndromes (MDS)· 2 Myelofibrosis· 2 Follicular lymphoma· 2 Mantle cell lymphoma· 2 Marginal zone lymphoma· 2 Neuroendocrine tumors· 2 Small cell lung cancer· 1 Gastrointestinal cancer· 1 Bladder cancer· 1 Glioma· 1 Brain cancer· 1 Acute myeloid leukemia (AML)· 1 Leukemia (other)· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Diffuse large B-cell lymphoma (DLBCL)· 1 Osteosarcoma· 1