Clinical Trials at University of Kentucky

As of September 2026, 106 paid clinical trials are recruiting at University of Kentucky, located at University of Kentucky Research Foundation, Kinkead Hall, 201 Kinkead Hall, Lexington, KY 40508, phone (859) 257-8311 in Lexington, Kentucky. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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108 clinical trials at University of Kentucky

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Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

for Osteomyelitis Tibia

Sites in Lexington +14 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05421741·Phase 4·Recruiting·Listed Jun 2022

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Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2

for Post Operative Surgical Site Infection

Sites in Lexington +30 more locations

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18 - 64

Code: NCT04678154·Phase 3·Recruiting·Listed Dec 2020

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Gamification Effects on the 6-Minute Walk Test in Children

for Neuromuscular Diseases in Children

1 location in Lexington

Sponsor: David Toupin

Sex: All·Age: 6 - 12

Code: NCT07216339·Recruiting·Listed Oct 2025

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Generating Novel Translational and Therapeutic Strategies Based on a Multicenter, Pediatric and AYA Evolutionary Tumor Board (pedsETB)

for Pediatric Cancer

Sites in Lexington +4 more locations

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: All ages

Code: NCT06423950·Recruiting·Listed May 2024

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A Phase Ib Study of VK-2019 in Patients With Relapsed or Refractory EBV+ Diffuse Large B-cell Lymphomas (DLBCL)

for Diffuse Large B Cell Lymphoma Refractory

1 location in Lexington

Sponsor: Pierluigi Porcu

Sex: All·Age: 18+

Code: NCT06789159·Phase 1·Recruiting·Listed Jan 2025

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Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

for Multiple System Atrophy

1 location in Lexington

Sponsor: Craig van Horne, MD, PhD

Sex: All·Age: 40 - 75

Code: NCT06683365·Phase 1·Recruiting·Listed Nov 2024

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A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery

for Parkinson's Disease

1 location in Lexington

Sponsor: Craig van Horne, MD, PhD

Sex: All·Age: 45 - 75

Code: NCT06683378·Phase 1·Recruiting·Listed Nov 2024

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The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

for Pre-diabetes

1 location in Lexington

Sponsor: Philip Kern

Sex: All·Age: 35 - 65·Accepts healthy volunteers

Code: NCT05051436·Phase 4·Recruiting·Listed Sep 2021

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Primary Subtalar Arthrodesis for Calcaneal Fractures

for Calcaneus Fracture

Sites in Lexington +16 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06249126·Recruiting·Listed Feb 2024

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A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia

for Disinfection By-products

1 location in Lexington

Sponsor: Anna Hoover

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05172752·Recruiting·Listed Dec 2021

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Circadian Rhythms in Postmenopausal Women

for Metabolic Syndrome

1 location in Lexington

Sponsor: Julie Pendergast

Sex: Female·Age: 45 - 65·Accepts healthy volunteers

Code: NCT04893226·Recruiting·Listed May 2021

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Prospective Evaluation of Pathways for Preterm Birth

for Preterm Birth

1 location in Lexington

Sponsor: John O'Brien, MD

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05246579·Recruiting·Listed Feb 2022

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Creating VIP Corps to Reduce Maternal Deaths

for Maternal Morbidity and Mortality

1 location in Lexington

Sponsor: Ann Coker

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06089109·Recruiting·Listed Oct 2023

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Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity

for Obesity and Overweight

1 location in Lexington

Sponsor: John Bauer

Sex: All·Age: 12 - 17

Code: NCT06967389·Recruiting·Listed May 2025

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Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

for Ankle Sprains

Sites in Lexington +1 more location

Sponsor: Danielle Torp

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06868316·Recruiting·Listed Mar 2025

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Impact of Daily Oral Cannabis Doses in Patients With Cancer

for Cancer

1 location in Lexington

Sponsor: Shanna Babalonis, PhD

Sex: All·Age: 18+

Code: NCT06601218·Phase 1·Recruiting·Listed Sep 2024

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Pembro With Radiation With or Without Olaparib

for Prostate Cancer

1 location in Lexington

Sponsor: Zin W Myint

Sex: Male·Age: 18+

Code: NCT05568550·Phase 2·Recruiting·Listed Oct 2022

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Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

for Mild Cognitive Impairment

1 location in Lexington

Sponsor: Julie Pendergast

Sex: Female·Age: 45 - 95

Code: NCT05858008·Recruiting·Listed May 2023

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Muscle Recovery After Critical Illness

for ICU Acquired Weakness

1 location in Lexington

Sponsor: Esther Dupont-Versteegden

Sex: Male·Age: 18+

Code: NCT05537298·Recruiting·Listed Sep 2022

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Comprehensive Connected Cancer Care (C4): Intervention Evaluation

for Cancer

1 location in Lexington

Sponsor: Timothy Mullett

Sex: All·Age: 18+

Code: NCT06326567·Recruiting·Listed Mar 2024

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K23- Physical Self Regulation vs Placebo

for Temporomandibular Disorder

1 location in Lexington

Sponsor: Ian Boggero, PhD

Sex: All·Age: 18+

Code: NCT06357702·Recruiting·Listed Apr 2024

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Bromelain for Post-surgery Facial Swelling

for Malocclusion

1 location in Lexington

Sponsor: Mohamed Bazina

Sex: All·Age: 18 - 65

Code: NCT07115212·Recruiting·Listed Aug 2025

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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

Sites in Lexington, Louisville +20 more locations

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting·Listed Feb 2022

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Intramedullary Calcium Sulfate Antibiotic Depot

for Open tíbia Fracture

Sites in Lexington +9 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05766670·Phase 3·Recruiting·Listed Mar 2023

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Loupe-Based Intraoperative Fluorescence Imaging

for Glioblastoma Multiforme

1 location in Lexington

Sponsor: Guoqiang Yu

Sex: All·Age: 18 - 90

Code: NCT04780009·Recruiting·Listed Mar 2021

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REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

for COVID-19

Sites in Lexington +4 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05218083·Recruiting·Listed Feb 2022

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Mechanisms for Activation of Beige Adipose Tissue in Humans

for PreDiabetes

1 location in Lexington

Sponsor: Philip Kern

Sex: All·Age: 35 - 65·Accepts healthy volunteers

Code: NCT04666636·Phase 2·Recruiting·Listed Dec 2020

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Opioid Drug Interaction Study

for Drug Interactions

1 location in Lexington

Sponsor: Shanna Babalonis, PhD

Sex: All·Age: 18 - 55

Code: NCT06757140·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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2024 Tirzepatide-Bariatric Surgery

for Obesity and Obesity-related Medical Conditions

Drug: Tirzepatide

1 location in Lexington

Sponsor: Marlene Starr

Sex: All·Age: 18+

Code: NCT06721507·Phase 4·Recruiting·Listed Dec 2024

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Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

Sites in Lexington +25 more locations

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting·Listed Jul 2022

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Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)

for Chronic Ankle Instability

Sites in Lexington +1 more location

Sponsor: Womack Army Medical Center

Sex: All·Age: 18 - 44

Code: NCT06527287·Recruiting·Listed Jul 2024

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Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment

for Lung Cancer

1 location in Lexington

Sponsor: Laurie McLouth

Sex: All·Age: 18+

Code: NCT06047301·Recruiting·Listed Sep 2023

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School Screening and Telemedicine Specialty Referral to Address Childhood Hearing Loss in Rural Kentucky

for Hearing Loss

1 location in Lexington

Sponsor: University of Arkansas

Sex: All·Age: 3 - 11·Accepts healthy volunteers

Code: NCT05513833·Recruiting·Listed Aug 2022

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Leveraging Community-clinical Linkages to Address Unmet Social Needs for People With Diabetes

for Diabetes

1 location in Lexington

Sponsor: Mary Lacy

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07196007·Recruiting·Listed Sep 2025

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Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC

for Peritoneal Carcinomatosis

Sites in Lexington +1 more location

Sponsor: Prakash Pandalai

Sex: All·Age: 18+

Code: NCT04779554·Phase 2·Recruiting·Listed Mar 2021

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Restoration of Hypoglycemia Awareness With Metoclopramide

for Hypoglycemia Unawareness

1 location in Lexington

Sponsor: Simon Fisher

Sex: All·Age: 20 - 60

Code: NCT03970720·Phase 2·Recruiting·Listed May 2019

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Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

for Aortic Aneurysm

Sites in Lexington +13 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04005976·Recruiting·Listed Jul 2019

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Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy

for Colorectal Cancer Metastatic

1 location in Lexington

Sponsor: Michael J Cavnar, MD

Sex: All·Age: 18 - 99

Code: NCT07201519·Phase 2·Recruiting·Listed Oct 2025

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InterTAN: Integrated Dual Screw Design Improve Biomechanics/Function Following Fixation Surgery

for Fracture of Hip

1 location in Lexington

Sponsor: Paul E. Matuszewski

Sex: All·Age: 55+

Code: NCT06024304·Recruiting·Listed Sep 2023

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Home-based Under Mattress Monitor for OSA

for Obstructive Sleep Apnea (OSAS)

1 location in Lexington

Sponsor: Isabel Moreno Hay

Sex: All·Age: 18 - 80

Code: NCT07186725·Recruiting·Listed Sep 2025

Apply to this trial