Paid Clinical Trials in Lexington, KY
As of July 2026, 450 paid clinical trials are recruiting in Lexington, Kentucky. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Lexington offers studies at sites including University of Kentucky for conditions such as Heart Failure, Acute Myeloid Leukemia, Breast Cancer, Malignant Solid Neoplasm. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Lexington
Trials by drug in Lexington
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Newly added in Lexington
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
A Phase 2 Study to Evaluate the Pharmacodynamics, Safety and Tolerability of BGE-102 in Participants With Obesity and Cardiovascular Risk Factors
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
408 clinical trials
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
Phase 2 Study to Assess the Safety and Efficacy of ANG003
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
A Study of Brenipatide in Participants With Opioid Use Disorder
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML
Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy
A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
Assessment of CCM in HF With Higher Ejection Fraction
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Top Research Study Locations in Lexington
Researchers run research studies in Lexington, KY at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Kentucky | Cancer, Alcohol Use Disorder, Ankle Sprains | 126 |
| University of Kentucky/Markey Cancer Center | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Metastatic Malignant Solid Neoplasm | 77 |
| Baptist Health Lexington | Breast Cancer, Coronary Artery Disease, Anatomic Stage II Breast Cancer AJCC v8 | 36 |
| Saint Joseph Radiation Oncology Resource Center | Prostate Adenocarcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Malignant Solid Neoplasm | 28 |
| Saint Joseph Hospital East | Prostate Adenocarcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma | 20 |
| CommonSpirit Saint Joseph Medical Center - East Lexington | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Cancer | 18 |
| Saint Joseph Hospital | Prostate Adenocarcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | 15 |
| University of Kentucky Medical Center | Adenocarcinoma, Pancreatic Ductal, Advanced Solid Tumor, Cachexia | 15 |
| Baptist Health Hamburg | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8 | 11 |
| CommonSpirit Saint Joseph Hospital - Lexington | Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Adenocarcinoma of the Colon | 10 |
| Kentucky Children's Hospital | Cancer-related Pain, Cardiac Arrest, Cardiopulmonary Arrest | 8 |
| University of Kentucky Chandler Medical Center | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 8 |
| University of Kentucky Markey Cancer Center | Lung Cancer Screening, Advanced Solid Tumor, Bladder Cancer | 8 |
| Markey Cancer Center | BRAF Gene Mutation, Cancer of Lung, Cancer of the Lung | 7 |
| Psychopharmacology of Addiction Laboratory | Methamphetamine Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder | 5 |
| University of Kentucky Research Foundation | Ankylosing Spondylitis, Autoimmune Diseases, Birdshot Chorioretinitis | 5 |
| The Research Group of Lexington LLC | Obesity, Cardiovascular Disease, Heart Failure | 4 |
| AMR Clinical | Cannabis Withdrawal, Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity | 3 |
| Baptist Health | Cervical Cancer, Non-Small Cell Lung Cancer, Ventricular Arrythmia | 3 |
| Lexington VA Health Care System | Lung Cancer Screening, Lung Cancer, Pulmonary Nodule, Solitary | 3 |
| Research Facility | Carcinoid, Carcinoid Tumor, GEP-NET | 3 |
| University of Kentucky - Markey Cancer Center | Advanced Liver Cancers, B-Cell Non-Hodgkins Lymphoma, Breast Cancer | 3 |
| University of Kentucky College of Medicine | Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC), Adolescent Congenital Heart Disease, Candidemia | 3 |
| University of Kentucky Hospital | Traumatic Brain Injury, Atrial Fibrillation, Intracerebral Hemorrhage | 3 |
| AMR Clinical - Lexington | Acute Migraine, Migraine | 2 |
Active & Upcoming Studies in Lexington (2026)
Recruiting trials in Lexington grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (178 active studies)
- A Phase Ib Study of VK-2019 in Patients With Relapsed or Refractory EBV+ Diffuse Large B-cell Lymphomas (DLBCL) · Phase 1 · Pierluigi Porcu
- PITCH - Impacting Hereditary Cancer Testing · Rachel Miller
Neurology & pain (33 active studies)
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- Repeated CBD Administration and Cannabis Outcomes · EARLY_Phase 1 · Hannah Harris
Cardiovascular (29 active studies)
Diabetes & metabolic (20 active studies)
- MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease · Oelisoa Andriankaja
- Time-restricted Eating for Patients With Type 2 Diabetes · Justin (Matt) Thomas
Mental health & behavior (11 active studies)
- Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis · EARLY_Phase 1 · Hannah Harris
- Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD · Phase 4 · Dr. Dean Reeves Clinic
Pediatric (8 active studies)
- MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease · Oelisoa Andriankaja
- Gamification Effects on the 6-Minute Walk Test in Children · David Toupin
HIV / STI (4 active studies)
- The PROTECT (PrEP Optimization Through Telehealth Care and Treatment) Trial · Hilary L Surratt, PhD
- Adaptive Intervention Strategies for HIV PrEP Care in Rural People Who Inject Drugs · Hilary L Surratt, PhD
Vaccines (2 active studies)
- Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults · Phase 1 · Clover Biopharmaceuticals USA, LLC
- REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19 · Duke University
Common conditions studied in Lexington
- Heart Failure (9 active studies)
- Acute Myeloid Leukemia (8 active studies)
- Breast Cancer (8 active studies)
- Malignant Solid Neoplasm (7 active studies)
- Obesity (7 active studies)
- Ovarian Cancer (7 active studies)
Leading research sponsors in Lexington
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- Children's Oncology Group
- NRG Oncology
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Lexington?
There are approximately 450 recruiting clinical trials in Lexington, Kentucky listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Lexington pay participants?
Most recruiting trials in Lexington compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Lexington?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Lexington?
The most common conditions under active study in Lexington include Heart Failure (9), Acute Myeloid Leukemia (8), Breast Cancer (8), Malignant Solid Neoplasm (7), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Lexington?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Lexington on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Lexington?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Lexington?
Recruiting research sites in Lexington include University of Kentucky, University of Kentucky/Markey Cancer Center, Baptist Health Lexington, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Lexington right now?
The largest active categories in Lexington are Cancer & tumors (178), Neurology & pain (33), Cardiovascular (29). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.