Clinical Trials at USC / Norris Comprehensive Cancer Center

As of August 2026, 74 paid clinical trials are recruiting at USC / Norris Comprehensive Cancer Center, located at 1200 N STATE ST, LOS ANGELES, CA 90033-1029, phone (323) 409-1313 in Los Angeles, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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74 clinical trials at USC / Norris Comprehensive Cancer Center

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MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial

for Malignant Testicular Germ Cell Tumor

Sites in Los Angeles, Loma Linda +4 more locations

Sponsor: University of Southern California

Sex: Male·Age: 18+

Code: NCT06060873·Recruiting·Listed Sep 2023

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Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma

for Advanced NUT Carcinoma

Sites in Los Angeles +4 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05019716·Phase 1, Phase 2·Recruiting·Listed Aug 2021

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Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

for Metastatic Dedifferentiated Liposarcoma

Drug: Peposertib

Sites in Los Angeles +14 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05711615·Phase 1·Recruiting·Listed Feb 2023

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Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for Anatomic Stage III Breast Cancer AJCC v8

Sites in Los Angeles, Newport Beach +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05372640·Phase 1·Recruiting·Listed May 2022

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Multilevel Determinants of Socioeconomic Disparities in Geographic Late-Stage Hepatocellular Carcinoma Hotspots

for Hepatocellular Carcinoma

1 location in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT07312162·Recruiting·Listed Dec 2025

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Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

for Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation

Sites in Los Angeles, Duarte +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT05691465·Phase 2·Recruiting·Listed Jan 2023

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Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

for Clinical Stage III Cutaneous Melanoma AJCC v8

Sites in Los Angeles, La Jolla +23 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05896839·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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Breast Cancer Screening Adherence for Women at Moderate Risk for Breast Cancer

for Breast Carcinoma

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 30 - 75·Accepts healthy volunteers

Code: NCT07076147·Recruiting·Listed Jul 2025

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Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

for Bone Pain

Sites in Los Angeles, Duarte +7 more locations

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT03858205·Recruiting·Listed Feb 2019

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Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery

for Anatomic Stage 0 Breast Cancer AJCC v8

1 location in Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT06297265·Recruiting·Listed Mar 2024

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Golf Recreational Exercise for Enhanced Survivorship in Prostate Cancer Survivors

for Localized Prostate Carcinoma

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: Male·Age: 55 - 85

Code: NCT06500169·Recruiting·Listed Jul 2024

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Characterization of T-cell Repertoire in Patients With Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant

for Acute Myeloid Leukemia

1 location in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT03921047·Recruiting·Listed Apr 2019

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Confronting Cancer as a Community

for Colorectal Carcinoma

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT06063928·Recruiting·Listed Oct 2023

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Pharmacogenomics of Asparaginase Induced Hepatotoxicity

for Acute Lymphoblastic Leukemia

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT03568266·Recruiting·Listed Jun 2018

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Breast Cancer Survivorship Biorepository

for Anatomic Stage I Breast Cancer AJCC v8

1 location in Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT05786664·Recruiting·Listed Mar 2023

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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Los Angeles, Beverly Hills +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

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A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer

for Triple Negative Breast Cancer

1 location in Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT05989828·Phase 1·Recruiting·Listed Aug 2023

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Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

Sites in Los Angeles, Bellflower +146 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting·Listed Mar 2021

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Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD

for Lung Non-Small Cell Carcinoma

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT07186699·Recruiting·Listed Sep 2025

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Norris ORIEN Total Cancer Care

for Cancer Risk

1 location in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT02970045·Recruiting·Listed Nov 2016

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An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

for Head and Neck Carcinoma

1 location in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT06420219·Recruiting·Listed May 2024

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S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

for Cardiotoxicity

Sites in Los Angeles, Torrance +142 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03418961·Phase 3·Recruiting·Listed Feb 2018

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Los Angeles, Tarzana +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Los Angeles, Long Beach +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

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Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers

for Healthy Subject

1 location in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT03207854·Recruiting·Listed Jul 2017

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Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

for Clonal Cytopenia of Undetermined Significance

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT06063486·Phase 2·Recruiting·Listed Oct 2023

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Access to Genetic Testing in Underserved Patients With Cancer

for Breast Carcinoma

Sites in Los Angeles +1 more location

Sponsor: University of Southern California

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06422455·Recruiting·Listed May 2024

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A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis

for Breast Carcinoma

Sites in Los Angeles & Newport Beach

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT06336928·Recruiting·Listed Mar 2024

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Longitudinal Advanced Prostate Cancer Cohort (LAPCC)

for Prostate Carcinoma

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: Male·Age: 18+

Code: NCT06067295·Recruiting·Listed Oct 2023

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Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer

for Metastatic Colorectal Adenocarcinoma

Drug: Botensilimab

Sites in Los Angeles & Fullerton

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT06336902·Phase 1·Recruiting·Listed Mar 2024

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Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses

for Breast Carcinoma

2 locations in Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT06171607·Phase 1·Recruiting·Listed Dec 2023

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International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

for Squamous Cell Carcinoma of the Penis, Usual Type

Sites in Los Angeles +5 more locations

Sponsor: Institute of Cancer Research, United Kingdom

Sex: Male·Age: 18+

Code: NCT02305654·Phase 3·Recruiting·Listed Dec 2014

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Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in Los Angeles, Beverly Hills +61 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07441681·Phase 3·Recruiting·Listed Mar 2026

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Ramucirumab and Trifluridine/Tipiracil or Paclitaxel for the Treatment of Patients With Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer

for Clinical Stage III Gastric Cancer AJCC v8

Sites in Los Angeles +7 more locations

Sponsor: Academic and Community Cancer Research United

Sex: All·Age: 18+

Code: NCT04660760·Phase 2·Recruiting·Listed Dec 2020

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