Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain

for Diabetic Peripheral Neuropathic Pain

Drug: LY4065967

36 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07285018·Phase 2·Recruiting

Apply to this trial

HEALEY ALS Platform Trial - Regimen I NUZ-001

for Amyotrophic Lateral Sclerosis (ALS)

1 location in Boston

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT07410806·Phase 2, Phase 3·Enrolling By Invitation

COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

50 locations incl. Bakersfield

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449936·Phase 3·Recruiting

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Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy

for Head Neck Cancer

6 locations incl. Boston

Sponsor: University of Virginia

Sex: All·Age: 18 - 85

Code: NCT07405645·Recruiting

Apply to this trial

Energy Dense Fueling for Cold-Weather Operations

for Cold Exposure

1 location in Natick

Sponsor: United States Army Research Institute of Environmental Medicine

Sex: All·Age: 18 - 39·Accepts healthy volunteers

Code: NCT07489690·Recruiting

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Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

for Menopausal Women

Drug: Daridorexant

5 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 40 - 62

Code: NCT07136415·Phase 4·Recruiting

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

18 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting

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A Study of Brenipatide in Participants With Opioid Use Disorder

for Opioid Use Disorder

Drug: Brenipatide

38 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07420283·Phase 2·Recruiting

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Adoptive T Cell Therapy With DC/AML Fusion Vaccine Plus Decitabine and Venetoclax in AML

for Acute Myeloid Leukemia

Drug: Venetoclax

1 location in Boston

Sponsor: David Avigan

Sex: All·Age: All ages

Code: NCT07374029·Phase 1·Recruiting

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Rituximab Plus Venetoclax in Front Line Marginal Zone Lymphoma

for Lymphoma

Drug: Venetoclax

1 location in Boston

Sponsor: Gottfried von Keudell, MD PhD

Sex: All·Age: 18+

Code: NCT06510309·Phase 2·Recruiting

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Distance-Based Exercise to Preserve Function and Prevent Disability

for Hematopoietic and Lymphatic System Neoplasm

17 locations incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884·Recruiting

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A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

for Hypertensive Disorder of Pregnancy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07312227·Recruiting

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Improving Outcomes of Older Adults Undergoing Ostomy Surgery

for Ostomy - Ileostomy or Colostomy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07424586·EARLY_Phase 1·Recruiting

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Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for Solid Tumor

Drug: Givastomig

3 locations incl. Goodyear

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT07432295·Phase 2·Recruiting

Apply to this trial

Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary Cancer

for Hereditary Cancer Syndromes

1 location in Boston

Sponsor: Nest Genomics

Sex: All·Age: 18 - 49

Code: NCT06654466·Recruiting

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

13 locations incl. Los Angeles

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting

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A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

for Sepsis

16 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18 - 80

Code: NCT07215702·Phase 2·Recruiting

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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for Carcinoma, Renal Cell

Drug: PF-08634404

101 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227415·Phase 1, Phase 2·Recruiting

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TIL Therapy in cSCC and MCC

for Cutaneous Squamous Cell Carcinoma

1 location in Boston

Sponsor: Karam Khaddour, MD, MS

Sex: All·Age: 18+

Code: NCT07288073·Phase 2·Recruiting

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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

for Overweight

Drug: Eloralintide

54 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07392190·Phase 3·Recruiting

Apply to this trial

A Study of Brenipatide in Adult Participants With Schizophrenia

for Schizophrenia

Drug: Brenipatide

31 locations incl. Little Rock

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 55

Code: NCT07410507·Phase 2·Recruiting

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Identifying Substance Use Consequences

for Substance Use Disorder (SUD)

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18+

Code: NCT07503067·Recruiting

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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

for Osteoarthritis

Drug: Eloralintide

37 locations incl. Mobile

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07353931·Phase 3·Recruiting

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A Study of Brenipatide in Adult Participants With Major Depressive Disorder

for Depressive Disorder, Major

Drug: Brenipatide

32 locations incl. Moorpark

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07412756·Phase 3·Recruiting

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

29 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07266441·Phase 2·Recruiting

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A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

for Advanced Solid Tumor

6 locations incl. Boston

Sponsor: Ipsen

Sex: All·Age: 18+

Code: NCT07213830·Phase 1, Phase 2·Recruiting

Apply to this trial

A Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors

for Advanced Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07227623·Recruiting

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A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

for Obesity

Drug: Eloralintide

41 locations incl. Tuscaloosa

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07321886·Phase 3·Recruiting

Apply to this trial

A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus

for Type II Diabetes Mellitus

31 locations incl. Birmingham

Sponsor: Corxel Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT07340320·Phase 2·Recruiting

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Piloting a Deaf Accessible Pre-Treatment for AUD

for Alcohol Use Disorder

1 location in Shrewsbury

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07269119·Recruiting

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A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia

for Dystonia

37 locations incl. Birmingham

Sponsor: Vima Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07304089·Phase 2·Recruiting

Apply to this trial

Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital

for Serious Mental Illness

1 location in Worcester

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07359157·Recruiting

Apply to this trial

SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

11 locations incl. Los Angeles

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting

Apply to this trial

Genetics of Neonatal Encephalopathy and Related Disorders

for Neonatal Encephalopathy

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT07165938·Recruiting

Apply to this trial

INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes

for Type 1 Diabetes Mellitus

10 locations incl. Los Angeles

Sponsor: Mannkind Corporation

Sex: All·Age: 10 - 17

Code: NCT07224321·Phase 2·Recruiting

Apply to this trial

Voice Therapy Per the Rehabilitation Treatment Specification System

for Muscle Tension Dysphonia

5 locations incl. Atlanta

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+

Code: NCT06152627·Recruiting

Apply to this trial

Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness

for Persian Gulf Syndrome

10 locations incl. Berkeley

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT06716411·Recruiting

Apply to this trial

CF Wellness Program

for Cystic Fibrosis (CF)

3 locations incl. Denver

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT07071324·Recruiting

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Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

for Prosthetic-joint Infection

9 locations incl. Sarasota

Sponsor: Peptilogics

Sex: All·Age: 18 - 80

Code: NCT07214311·Phase 2, Phase 3·Recruiting

Apply to this trial

Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy)

for Relapsed / Refractory Osteosarcoma

2 locations incl. Los Angeles

Sponsor: Lantheus Medical Imaging

Sex: All·Age: 12+

Code: NCT07357519·Phase 1, Phase 2·Recruiting

Apply to this trial