Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

for Obesity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 99

Code: NCT07226947·Recruiting

Apply to this trial

A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

for Epileptic Encephalopathy

6 locations incl. Orange

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 2 - 12

Code: NCT07227857·Phase 1, Phase 2·Recruiting

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A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

for Bipolar Disorder

Drug: Brenipatide

20 locations incl. Orange

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07286175·Phase 2·Recruiting

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Alzheimer's Registry

for Alzheimer Disease

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07420075·Enrolling By Invitation

Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)

for Fragile X Syndrome

15 locations incl. Phoenix

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: Male·Age: 13 - 45

Code: NCT07209462·Phase 2·Recruiting

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Training Inner Speech in Children With Developmental Language Disorder

for Developmental Language Disorder

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 8 - 10·Accepts healthy volunteers

Code: NCT06880731·Recruiting

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Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants

for Macular Telangiectasia Type 2 (MacTel)

23 locations incl. La Jolla

Sponsor: Neurotech Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06971939·Phase 4·Recruiting

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A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia

for Waldenström Macroglobulinemia

Drug: Pacritinib

1 location in Boston

Sponsor: Shayna Sarosiek, MD

Sex: All·Age: 18+

Code: NCT06986174·Phase 2·Recruiting

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Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

for Diabetic Peripheral Neuropathic Pain

75 locations incl. Birmingham

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT07231419·Phase 3·Recruiting

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A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

for Colorectal Cancer

5 locations incl. Boston

Sponsor: PAQ Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07300150·Phase 1·Recruiting

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OnTrackCF: Engagement, Feasibility, and Acceptability Study

for Cystic Fibrosis (CF)

3 locations incl. Birmingham

Sponsor: Boston Children's Hospital

Sex: All·Age: 18+

Code: NCT07031323·Recruiting

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Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome

for Endometrial Cancer

1 location in Boston

Sponsor: Jessica D. St. Laurent, MD

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07220239·Recruiting

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Zymfentra (Infliximab-dyyb) REal World Cohort STudy

for Ulcerative Colitis (UC)

9 locations incl. New Haven

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237516·Recruiting

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BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women

for Depressive Symptoms

2 locations incl. Winter Garden

Sponsor: BTL Industries Ltd.

Sex: Female·Age: 40+

Code: NCT07413705·Recruiting

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Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

26 locations incl. Alabaster

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT07161037·Phase 2·Recruiting

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A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction

for Left Ventricular Systolic Dysfunction

Drug: Finerenone

22 locations incl. Aurora

Sponsor: Bayer

Sex: All·Age: 6 Months - 17

Code: NCT07188805·Phase 3·Recruiting

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Impact of Pectoral Versus Paravertebral Blocks on Pain and Physical Well-Being in Implant-Based Breast Reconstruction

for Breast Reconstruction

1 location in Boston

Sponsor: Amy Colwell

Sex: All·Age: 18+

Code: NCT07209436·Recruiting

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BAY3401016; Biomarker Study Alport

for Alport Syndrome

6 locations incl. Birmingham

Sponsor: Bayer

Sex: All·Age: 18 - 45

Code: NCT07211685·Phase 2·Recruiting

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Oral Surgery Virtual Reality Glasses Study

for Procedural Anxiety

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 16 - 65

Code: NCT06723158·Recruiting

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Endovascular Repair With Fenestrated TREO Stent-Graft System in AAA

for Abdominal Aortic Aneurysms (AAA)

7 locations incl. Colorado Springs

Sponsor: Bolton Medical

Sex: All·Age: 18+

Code: NCT07026877·Recruiting

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Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

for Drain Output After Breast Reduction Surgery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07131592·Phase 4·Recruiting

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Investigating the Effects of Social Stress on Brain Imaging

for Social Stress

1 location in Cambridge

Sponsor: Massachusetts Institute of Technology

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT05591404·Recruiting

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Postural Perturbations Tracing to the Stomatognathic System

for Posture

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 30 - 65

Code: NCT06974591·Recruiting

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ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

for Metastatic Breast Cancer

1 location in Boston

Sponsor: Kristina A. Fanucci

Sex: All·Age: 18+

Code: NCT07198724·Phase 1, Phase 2·Recruiting

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A Multicenter, Prospective Blood Collection Study in a Kidney Transplant Population

for Kidney Disease

6 locations incl. San Diego

Sponsor: Devyser Inc.

Sex: All·Age: 18+

Code: NCT07006831·Recruiting

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Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for Esophageal Cancer

14 locations incl. Cerritos

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217704·Phase 3·Recruiting

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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

for Major Depressive Disorder (MDD)

21 locations incl. Birmingham

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07284667·Phase 2·Recruiting

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A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)

for Multiple Sclerosis

9 locations incl. Carlsbad

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18 - 65

Code: NCT07074886·Phase 2·Recruiting

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A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

42 locations incl. Mobile

Sponsor: Incyte Corporation

Sex: Female·Age: 18 - 99

Code: NCT07023627·Phase 2·Recruiting

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A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

for Alzheimers Disease

Drug: Trontinemab

33 locations incl. Phoenix

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 90

Code: NCT07170150·Phase 3·Recruiting

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A Study of NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome

for Phelan-McDermid Syndrome

9 locations incl. Glendale

Sponsor: Neuren Pharmaceuticals Limited

Sex: All·Age: 3 - 12

Code: NCT07281079·Phase 3·Recruiting

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A Virtual Reality Vaping Prevention Intervention for Adolescents

for Vaping

2 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 12 - 15·Accepts healthy volunteers

Code: NCT07362069·Enrolling By Invitation

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

for Secondary Progressive Multiple Sclerosis (SPMS)

Drug: Remibrutinib

30 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07225504·Phase 3·Recruiting

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A Study of Pirtobrutinib, Venetoclax, and Rituximab in People With Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)

for Waldenstrom Macroglobulinemia

Drug: Venetoclax

9 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07231952·Phase 2·Recruiting

Apply to this trial

Germline Testing for Predisposition to Myeloid Malignancies

for Myeloid Malignancy

1 location in Boston

Sponsor: Christopher Reilly

Sex: All·Age: 18+

Code: NCT07112287·Recruiting

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A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

for Eosinophilic Esophagitis (EoE)

Drug: Dupilumab

10 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 6 Months - 6

Code: NCT07112378·Phase 3·Recruiting

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A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO)

for Hypothalamic Obesity

6 locations incl. Aurora

Sponsor: Rhythm Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07156578·Phase 2·Enrolling By Invitation

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

for Ulcerative Colitis

Drug: LY4268989

41 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07186101·Phase 2·Recruiting

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REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study

for Disorders of Consciousness

1 location in Boston

Sponsor: Samuel Snider, MD

Sex: All·Age: 18 - 55

Code: NCT07228286·EARLY_Phase 1·Recruiting

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A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

for Atrial Fibrillation (AF)

32 locations incl. Birmingham

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07187115·Recruiting

Apply to this trial