Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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3,593 clinical trials

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Germline Testing for Predisposition to Myeloid Malignancies

for Myeloid Malignancy

1 location in Boston

Sponsor: Christopher Reilly

Sex: All·Age: 18+

Code: NCT07112287·Recruiting

Apply to this trial

A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

for Eosinophilic Esophagitis (EoE)

Drug: Dupilumab

10 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 6 Months - 6

Code: NCT07112378·Phase 3·Recruiting

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A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO)

for Hypothalamic Obesity

6 locations incl. Aurora

Sponsor: Rhythm Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07156578·Phase 2·Enrolling By Invitation

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

for Ulcerative Colitis

Drug: LY4268989

41 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07186101·Phase 2·Recruiting

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REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study

for Disorders of Consciousness

1 location in Boston

Sponsor: Samuel Snider, MD

Sex: All·Age: 18 - 55

Code: NCT07228286·EARLY_Phase 1·Recruiting

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A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

for Atrial Fibrillation (AF)

32 locations incl. Birmingham

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07187115·Recruiting

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Treatment of Perioral Wrinkles Using Topical Poly-L-lactic Acid and Microneedling Device

for Perioral Wrinkles

1 location in Chestnut Hill

Sponsor: Skincare Physicians of Chestnut Hill

Sex: All·Age: 40 - 70

Code: NCT07225348·Phase 4·Recruiting

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A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

for Head and Neck Squamous Cell Carcinoma HNSCC

6 locations incl. Denver

Sponsor: Sutro Biopharma, Inc.

Sex: All·Age: 18+

Code: NCT07227168·Phase 1·Recruiting

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Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for Extensive Stage Lung Small Cell Carcinoma

148 locations incl. Loma Linda

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06769126·Phase 2·Recruiting

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A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

14 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting

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Diffuse Cutaneous Scleroderma (DSSc) SFDI Study

for Systemic Scleroderma

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07090226·Recruiting

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Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT

for Lack of Keratinized Gingiva

1 location in Boston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: 20 - 80·Accepts healthy volunteers

Code: NCT07440303·Recruiting

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Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

for Obesity

Drug: Tirzepatide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05933499·Phase 2·Recruiting

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Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

for Non-Small Cell Lung Cancer

28 locations incl. Irvine

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07100080·Phase 2, Phase 3·Recruiting

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Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

for Nursing Home Resident

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07220486·Recruiting

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ACT Lung Health Intervention: Phase Two

for Smoking Cessation

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06945120·Recruiting

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Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking

for Repetitive Negative Thinking

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 13 - 21·Accepts healthy volunteers

Code: NCT07055217·Recruiting

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The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project

for Burnout, Professional

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07221422·Recruiting

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Mirai-MRI: Validation of AI Models for Breast Cancer Risk

for Cancer Risk

4 locations incl. San Diego

Sponsor: University of California, San Francisco

Sex: Female·Age: 40 - 89·Accepts healthy volunteers

Code: NCT07121972·Recruiting

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Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults

for COVID-19

2 locations incl. Colorado Springs

Sponsor: CastleVax Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07215520·Phase 2·Recruiting

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De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia

for Congenital Diaphragmatic Hernia

19 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 Months - 1 Month

Code: NCT05213676·Phase 4·Recruiting

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SLN Mapping and ICG Dye for Vulvar Cancer

for Vulva Cancer

1 location in Boston

Sponsor: Tufts Medical Center

Sex: Female·Age: 18+

Code: NCT06035068·Not Yet Recruiting

CCM OPEN HF Registry

for Heart Failure

28 locations incl. Mesa

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT07112924·Recruiting

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SAINT in Postpartum Depression (PPD)

for Postpartum Depression (PPD)

4 locations incl. Worcester

Sponsor: Magnus Medical

Sex: Female·Age: 18 - 45

Code: NCT07210255·Recruiting

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Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.

for Infertility (IVF Patients)

16 locations incl. Encino

Sponsor: Granata Bio Corporation

Sex: Female·Age: 18 - 42

Code: NCT07216742·Phase 3·Recruiting

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I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

56 locations incl. Birmingham

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting

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Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

for Amputation

2 locations incl. Chicago

Sponsor: Liberating Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07011420·Recruiting

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Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

for Fibromyalgia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT07023523·Recruiting

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A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

for Uncontrolled Hypertension

20 locations incl. San Jose

Sponsor: Retension Pharmaceuticals. Inc.

Sex: All·Age: 18 - 70

Code: NCT07142356·Phase 2·Recruiting

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An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

for Dry Eye

5 locations incl. Newport Beach

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07179055·Phase 2·Recruiting

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Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

for Critical Illness

1 location in Boston

Sponsor: Wandercraft

Sex: All·Age: 18+

Code: NCT07220733·Phase 1, Phase 2·Recruiting

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

50 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting

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Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

for Opioid Use Disorder

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06732596·Recruiting

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Optimizing Care Transition Process for Older Colorectal Surgery Patients

for Colorectal Surgery

1 location in Salem

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT06752031·Recruiting

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A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

for Eosinophilic Esophagitis

41 locations incl. Little Rock

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06851559·Phase 2·Recruiting

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Well-being in IBS: Strengths and Happiness (WISH) 2.0

for Irritable Bowel Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06866106·Recruiting

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ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

for Breast Neoplasms

Drug: Pumitamig

26 locations incl. Springdale

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07173751·Phase 3·Recruiting

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Synergistic Gut-brain Axis Modulation Via Vagal Stimulation and Support Therapy in Functional Dyspepsia

for Functional Dyspepsia

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 65

Code: NCT06360900·Recruiting

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Cranberry and Gut Health in Crohn's Disease

for Crohn Disease (CD)

1 location in Worcester

Sponsor: Ana Maldonado-Contreras

Sex: All·Age: 18 - 65

Code: NCT07170462·EARLY_Phase 1·Recruiting

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A Phase 1/2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome

for Angelman Syndrome

3 locations incl. Los Angeles

Sponsor: MavriX Bio, LLC

Sex: All·Age: 4 - 50

Code: NCT07181837·Phase 1, Phase 2·Recruiting

Apply to this trial