Paid Clinical Trials in Massachusetts

Massachusetts has 3,593 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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3,593 clinical trials

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Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07072039·Recruiting

Apply to this trial

Striae Distensae Treatment Using Deep Skin Abrasion

for Striae Distensae

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 18 - 70

Code: NCT07087405·Recruiting

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Optimal Ventilation for Cardiac Arrest

for Cardiac Arrest (CA)

20 locations incl. Orange

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 37 Weeks - 18

Code: NCT07114510·Recruiting

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Study of COYA 302 for the Treatment of ALS

for Amyotrophic Lateral Sclerosis (ALS)

21 locations incl. Phoenix

Sponsor: Coya Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07161999·Phase 2·Recruiting

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Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

11 locations incl. Fayetteville

Sponsor: AstraZeneca

Sex: Male·Age: 18 - 130

Code: NCT07181161·Phase 1, Phase 2·Recruiting

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

93 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184931·Phase 3·Recruiting

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Imagined Acupuncture for Postoperative Pain After Spinal Surgery

for Pain Management

1 location in Boston

Sponsor: Jingping Wang, MD, Ph.D.

Sex: All·Age: 18+

Code: NCT07197710·Recruiting

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OpenEvidence Safety and Comparative Efficacy of Four LLM's in Clinical Practice

for AI (Artificial Intelligence)

1 location in Cambridge

Sponsor: Cambridge Health Alliance

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07199231·Enrolling By Invitation

Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)

for Diabetes Mellitus, Type 2

3 locations incl. Stanford

Sponsor: Stanford University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06251323·Recruiting

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Study of Novel Therapeutics for Acute Remedy of Colitis

for Ulcerative Colitis

2 locations incl. Chestnut Hill

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT06420492·Phase 2·Recruiting

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Clinical Course Of Disease In Participants With FA-CM

for Friedreich Ataxia

8 locations incl. La Jolla

Sponsor: Lexeo Therapeutics

Sex: All·Age: 6+

Code: NCT06865482·Recruiting

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Circulating Tumor DNA

for ER+ Breast Cancer

7 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT06923527·Phase 2·Recruiting

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Biomarkers to Enhance Early Schizophrenia Treatment

for Schizophenia Disorder

4 locations incl. Birmingham

Sponsor: Northwell Health

Sex: All·Age: 18 - 35

Code: NCT06969755·Phase 4·Recruiting

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A Study to Evaluate the Incidence of Clinically Suspicious Lambert-Eaton Myasthenic Syndrome (LEMS) in Subjects Diagnosed With Small Cell Lung Cancer (SCLC)

for Small Cell Lung Cancer ( SCLC )

1 location in Boston

Sponsor: Addario Lung Cancer Medical Institute

Sex: All·Age: 18+

Code: NCT07075627·Not Yet Recruiting

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

for Urothelial Cancer

35 locations incl. Gilbert

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07106762·Phase 2, Phase 3·Recruiting

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A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

for Relapsed or Refractory Multiple Myeloma

10 locations incl. Birmingham

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18+

Code: NCT07116616·Phase 1, Phase 2·Recruiting

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A Study To Assess The Feasibility Of Indivi Mobile Application In Monitoring Cognitive Performance In Aging Population

for Mild Cognitive Impairment (MCI)

1 location in Boston

Sponsor: Indivi AG

Sex: All·Age: 50 - 90·Accepts healthy volunteers

Code: NCT07174869·Recruiting

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A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer

for Prostate Cancer

6 locations incl. Orlando

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT07192614·Phase 1, Phase 2·Recruiting

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Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder

for Bipolar I or II Disorder

47 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT07220460·Phase 2·Recruiting

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Nucleoside Therapy in Patients With Telomere Biology Disorders

for Telomere Biology Disorders

1 location in Boston

Sponsor: Suneet Agarwal

Sex: All·Age: 1 - 70

Code: NCT06817590·Phase 1·Recruiting

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TLN-372 in Advanced KRAS Mutant Solid Tumors

for KRAS Mutant Solid Tumors

6 locations incl. Birmingham

Sponsor: Treeline Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07204340·Phase 1·Recruiting

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Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for Acute Myeloid Leukemia (AML)

42 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07007312·Phase 3·Recruiting

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Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

for Urothelial Cancer

38 locations incl. Fullerton

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07129993·Phase 2, Phase 3·Recruiting

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A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease

for Immunoglobulin G4 Related Disease

17 locations incl. Fontana

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07190196·Phase 3·Recruiting

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A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza

for Influenza

120 locations incl. Anniston

Sponsor: Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Sex: All·Age: 12+

Code: NCT07159763·Phase 3·Recruiting

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Advanta VXT and Flixene PMCF Registry

for Peripheral Arterial Disease

1 location in Boston

Sponsor: Atrium Medical Corporation

Sex: All·Age: 18+

Code: NCT07161583·Recruiting

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A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

for Hypothalamic Obesity

8 locations incl. Birmingham

Sponsor: Rhythm Pharmaceuticals, Inc.

Sex: All·Age: 4+

Code: NCT06760546·Phase 3·Recruiting

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A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

for Breast Cancer

14 locations incl. Orlando

Sponsor: Terremoto Biosciences Inc.

Sex: All·Age: 18+

Code: NCT07109726·Phase 1, Phase 2·Recruiting

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A Study of PHN-012 in Patients With Advanced Solid Tumors

for Colon Cancer

11 locations incl. Los Angeles

Sponsor: Pheon Therapeutics

Sex: All·Age: 18+

Code: NCT07127874·Phase 1·Recruiting

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GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

16 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting

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DT2216 + Paclitaxel in Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

3 locations incl. Boston

Sponsor: Elizabeth Stover, MD, PhD

Sex: Female·Age: 18+

Code: NCT06964009·Phase 1·Recruiting

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Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia

for Aphasia

1 location in Springfield

Sponsor: University of Massachusetts, Amherst

Sex: All·Age: 18 - 59·Accepts healthy volunteers

Code: NCT06990997·Recruiting

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A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

for Chronic Obstructive Pulmonary Disease

Drug: Dupilumab

10 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 40 - 85

Code: NCT07053423·Phase 4·Recruiting

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BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement

for Stroke

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 35+

Code: NCT07091851·Recruiting

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Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

for Schizophrenia

Drug: KarXT

18 locations incl. Orange

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07101094·Recruiting

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A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

9 locations incl. Stanford

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07111520·Phase 1, Phase 2·Recruiting

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Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

for Plaque Psoriasis

Drug: Deucravacitinib

122 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40+

Code: NCT07116967·Phase 3·Recruiting

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A Study of YL242 in Subjects With Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. New Haven

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT07197827·Phase 1, Phase 2·Recruiting

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Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap

for Neuroma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 22+

Code: NCT06915662·Phase 2·Recruiting

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Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

for Cystic Fibrosis (CF)

18 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 12+

Code: NCT06837181·Recruiting

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