Paid Clinical Trials in Massachusetts

Massachusetts has 3,593 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

3,593 clinical trials

↓ Download CSV

A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients

for Breast Cancer Screening

6 locations incl. Los Angeles

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06934239·Phase 4·Recruiting

Apply to this trial

Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 30 - 75

Code: NCT07087431·Recruiting

Apply to this trial

Open Label Treprostinil Raynaud's Study

for Raynaud's Disease

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07112183·Phase 4·Recruiting

Apply to this trial

Impact of Earplugs on Mechanisms of Noise-Related Cardiovascular Disease

for Cardiometabolic Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07148817·Recruiting

Apply to this trial

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

for Metabolic Dysfunction-Associated Steatotic Liver Disease

140 locations incl. Tuscaloosa

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07165028·Phase 3·Recruiting

Apply to this trial

An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)

for Progressive Metastatic Castrate Resistant Prostate Cancer

Drug: Tulmimetostat

6 locations incl. Denver

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT07206056·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

for Alcohol Use Disorder

Drug: Brenipatide

30 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219966·Phase 3·Recruiting

Apply to this trial

Long-Term Stability of the Glide Control Strategy

for Upper Limb Amputation Above Elbow

10 locations incl. Annapolis

Sponsor: Infinite Biomedical Technologies

Sex: All·Age: 18+

Code: NCT07222085·Recruiting

Apply to this trial

Pain Disengagement Training (Open Pilot)

for Chronic Musculoskeletal Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06870162·Recruiting

Apply to this trial

Groceries for Residents of Southeastern USA to Stop Hypertension

for Hypertension

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06891911·Recruiting

Apply to this trial

Improving Lipid Optimization Quality and Treatment Options in ASCVD

for Hypercholesterolemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 95

Code: NCT06960655·Enrolling By Invitation

Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure

for Blast Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18 - 50

Code: NCT07131475·Phase 2·Recruiting

Apply to this trial

A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer

for Small-cell Lung Cancer

20 locations incl. Denver

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT07174583·Phase 1, Phase 2·Recruiting

Apply to this trial

Subcortical Arousal in Perceptual Awareness

for Epilepsy

8 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting

Apply to this trial

Breaking Silence Through Story: A Narrative Medicine Intervention for Parents of Children With Urogenital Conditions

for DSD

1 location in Boston

Sponsor: Sarah Schlegel

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06989593·Recruiting

Apply to this trial

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

for Stomach Cancer Stage IV

Drug: Ivonescimab

2 locations incl. Santa Monica

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07070466·Phase 2·Recruiting

Apply to this trial

Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study

for PFO

5 locations incl. Los Angeles

Sponsor: Recross Cardio, Inc.

Sex: All·Age: 18 - 65

Code: NCT07172464·Recruiting

Apply to this trial

Social Needs Screening and Chronic Diseases Study (WE CARE)

for Hyperlipidemias

3 locations incl. Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06903897·Recruiting

Apply to this trial

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Drug: Duvakitug

91 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184996·Phase 3·Recruiting

Apply to this trial

Advancing Student Suicide Interventions With Scalable Technologies

for Suicidal Ideation

1 location in Amherst

Sponsor: University of Massachusetts, Amherst

Sex: All·Age: 18+

Code: NCT07211373·Enrolling By Invitation

Substrates for Post-Stroke Arm Rehabilitation

for Stroke Rehabilitation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06998485·Recruiting

Apply to this trial

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

for Muscle Invasive Bladder Urothelial Carcinoma

211 locations incl. Fort Smith

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07097142·Phase 3·Recruiting

Apply to this trial

Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

for Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

6 locations incl. San Francisco

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07140900·Phase 1·Recruiting

Apply to this trial

Food Access, Value, and Optimization of Resources

for Food Insecurity

1 location in Jamaica Plain

Sponsor: Boston Children's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07149350·Enrolling By Invitation

A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

for Non-obstructive Hypertrophic Cardiomyopathy

22 locations incl. La Jolla

Sponsor: Imbria Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07023614·Phase 2·Recruiting

Apply to this trial

PDAC-PATHWAYS: A Digital Informational and Supportive Care App for Patients Initiating Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma

for PDAC - Pancreatic Ductal Adenocarcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07047807·Recruiting

Apply to this trial

Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

for Orthopaedic Related Pain (Musculoskeletal Pain)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07265557·Recruiting

Apply to this trial

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

for Inflammatory Bowel Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT05332639·Recruiting

Apply to this trial

Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software

for Chronic Pain

1 location in Cambridge

Sponsor: AugMend Health Inc.

Sex: All·Age: 18+

Code: NCT07336537·Recruiting

Apply to this trial

The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial

for Non-cardiac Surgical

3 locations incl. Boston

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06895590·Recruiting

Apply to this trial

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

for Solid Tumor Cancer

10 locations incl. San Francisco

Sponsor: Avenzo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07193511·Phase 1, Phase 2·Recruiting

Apply to this trial

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

Drug: Coramitug

61 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting

Apply to this trial

A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury

for Hypoxic-Ischemic Encephalopathy

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 3 Months - 6 Months

Code: NCT06429007·Phase 1·Enrolling By Invitation

Visual Arts Interventions With Older Adults

for Feasibility Study

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 55 - 85·Accepts healthy volunteers

Code: NCT06645652·Recruiting

Apply to this trial

Developing and Testing a Trauma-Informed Exercise Intervention for Women Veterans With Histories of Sexual Violence

for Sexual Violence

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: Female·Age: 21 - 65·Accepts healthy volunteers

Code: NCT06746740·Recruiting

Apply to this trial

Drug Screening of Cutaneous Lesions of Squamous Cell Carcinoma

for Squamous Cell Carcinoma of the Skin

1 location in Boston

Sponsor: Oliver Jonas

Sex: All·Age: 18+

Code: NCT06782399·EARLY_Phase 1·Enrolling By Invitation

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting

Apply to this trial

Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

for Traumatic Brain Injury

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 85

Code: NCT06848140·Recruiting

Apply to this trial

Losartan to Improve Outcomes After Multi-ligament Knee Injury

for Multi-ligament Knee Injury

3 locations incl. Lexington

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 40

Code: NCT06933706·Phase 2·Recruiting

Apply to this trial

Perineal Massage Using A Pelvic Wand During Pregnancy

for Pregnancy Related

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Female·Age: 18+

Code: NCT06986824·Phase 4·Recruiting

Apply to this trial