Paid Clinical Trials in Massachusetts

Massachusetts has 3,446 paid clinical trials enrolling now across cities including Boston, Worcester and Burlington. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,953 clinical trials

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for Low-grade Glioma

Sites in Boston +11 more locations

Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All·Age: 6 Months - 25

Code: NCT04775485·Phase 2·Recruiting·Listed Mar 2021

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Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS

for Interstitial Cystitis

Sites in Watertown +10 more locations

Sponsor: Vaneltix Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05737121·Phase 2·Recruiting·Listed Feb 2023

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A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

for Age-Related Macular Degeneration

Sites in Boston +11 more locations

Sponsor: Astellas Institute for Regenerative Medicine

Sex: All·Age: 50+

Code: NCT03178149·Phase 1·Recruiting·Listed Jun 2017

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Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)

for B-cell Acute Lymphoblastic Leukemia

Sites in Boston +12 more locations

Sponsor: Cellectis S.A.

Sex: All·Age: 15 - 50

Code: NCT04150497·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

for Pulmonary Arterial Hypertension

Sites in Boston +8 more locations

Sponsor: Aria CV, Inc

Sex: All·Age: 18+

Code: NCT04555161·Recruiting·Listed Sep 2020

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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

Sites in Boston +21 more locations

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting·Listed May 2023

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A Retrospective Assessment of OviTex PRS (OviTex)

for Reconstructive Surgical Procedures

Sites in Boston +6 more locations

Sponsor: Tela Bio Inc

Sex: Female·Age: 18 - 75

Code: NCT05736848·Recruiting·Listed Feb 2023

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SAfety of Regional Citrate Anticoagulation (SARCA Study)

for Acute Kidney Injury

Sites in Worcester +5 more locations

Sponsor: Fresenius Medical Care North America

Sex: All·Age: 18+

Code: NCT05339139·Phase 3·Recruiting·Listed Apr 2022

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A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).

for Intestinal Failure Associated Liver Disease

Sites in Boston +12 more locations

Sponsor: NorthSea Therapeutics B.V.

Sex: All·Age: 16+

Code: NCT05919680·Phase 2·Recruiting·Listed Jun 2023

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An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

for Mitral Regurgitation

Sites in Boston +7 more locations

Sponsor: HighLife SAS

Sex: All·Age: 18+

Code: NCT04029337·Recruiting·Listed Jul 2019

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Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

for Pulmonary Nodule, Solitary

Sites in Boston +21 more locations

Sponsor: Veracyte, Inc.

Sex: All·Age: 29 - 85

Code: NCT06426628·Recruiting·Listed May 2024

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Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

for Age-Related Macular Degeneration

Sites in Lawrence +9 more locations

Sponsor: VisionCare, Inc.

Sex: All·Age: 65+

Code: NCT05438732·Recruiting·Listed Jun 2022

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Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.

for Small Cell Lung Cancer

Sites in Boston +10 more locations

Sponsor: Chipscreen Biosciences, Ltd.

Sex: All·Age: 18+

Code: NCT05271292·Phase 1, Phase 2·Recruiting·Listed Mar 2022

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Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment

for Parenteral Nutrition Associated Liver Disease (PNALD)

Sites in Boston +9 more locations

Sponsor: Fresenius Kabi

Sex: All·Age: 1 Day - 17

Code: NCT06274788·Recruiting·Listed Feb 2024

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Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation (FLT3 Mut+)

for Acute Myeloid Leukemia, in Relapse

Drug: Iadademstat

Sites in Boston +12 more locations

Sponsor: Oryzon Genomics S.A.

Sex: All·Age: 18+

Code: NCT05546580·Phase 1·Recruiting·Listed Sep 2022

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Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

for Schizophrenia

Sites in Boston +17 more locations

Sponsor: Reviva Pharmaceuticals

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05184335·Phase 3·Recruiting·Listed Jan 2022

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A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Boston +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT07630974·Phase 1, Phase 2·Recruiting·Listed Jun 5, 2026

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Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease

for Dry Eye Disease (DED)

1 location in Andover

Sponsor: Andover Research Eye Institute

Sex: All·Age: 18+

Code: NCT07676084·Phase 4·Recruiting·Listed Jun 30, 2026

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A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

for Acute Treatment of Migraine

Drug: Rimegepant

Sites in Worcester +10 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07609914·Phase 4·Recruiting·Listed May 2026

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Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss

for GJB2-mediated Hearing Loss

Sites in Boston +2 more locations

Sponsor: Skylark Bio Inc.

Sex: All·Age: 9 Months - 7

Code: NCT07627971·Phase 1, Phase 2·Recruiting·Listed Jun 4, 2026

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A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)

for COPD (Chronic Obstructive Pulmonary Disease)

Sites in North Dartmouth +3 more locations

Sponsor: Windward Bio

Sex: All·Age: 40 - 80

Code: NCT07646587·Phase 2·Recruiting·Listed Jun 12, 2026

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A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

for Major Depressive Disorder (MDD)

Sites in Boston +16 more locations

Sponsor: Draig Therapeutics Ltd

Sex: All·Age: 18 - 75

Code: NCT07610473·Phase 2·Recruiting·Listed May 2026

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A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)

for LMNA-Related Dilated Cardiomyopathy

Sites in Boston +5 more locations

Sponsor: Nuevocor Pte. Ltd.

Sex: All·Age: 18+

Code: NCT07606274·Phase 1, Phase 2·Recruiting·Listed May 2026

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A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

for Advanced NRAS-Mutant Melanoma

Sites in Boston +8 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07584226·Phase 1·Recruiting·Listed May 2026

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Flo Digital Contraceptive Study

for Contraception Use

1 location in Boston

Sponsor: Flo Health Inc.

Sex: Female·Age: 18+

Code: NCT07630064·Recruiting·Listed Jun 5, 2026

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Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

for Advanced Microsatellite Stable Colorectal Cancer

Drug: Nivolumab

Sites in Boston +4 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07527858·Phase 2·Recruiting·Listed Apr 2026

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A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)

for Alopecia Areata

Drug: LY4005130

Sites in Boston +8 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 50

Code: NCT07533006·Phase 2·Recruiting·Listed Apr 2026

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A Double-blind, Placebo-controlled Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ

for TMJ

1 location in Acton

Sponsor: Erchonia Corporation

Sex: All·Age: 22 - 75

Code: NCT07600203·Recruiting·Listed May 2026

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A Clinical Study to Evaluate the Efficacy and Safety of Ultra in Promoting Hair Regrowth

for Androgenic Alopecia

Sites in Westford +1 more location

Sponsor: CynosureLutronic

Sex: All·Age: 22 - 70

Code: NCT07588243·Recruiting·Listed May 2026

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Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas

for HER2-negative

Drug: Nivolumab

1 location in Boston

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07546812·Phase 2·Recruiting·Listed Apr 2026

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A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder

for Bipolar I Disorder

1 location in Boston

Sponsor: Alzamend Neuro, Inc.

Sex: All·Age: 18 - 65

Code: NCT07540338·Phase 1, Phase 2·Recruiting·Listed Apr 2026

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Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)

for Erythropoietic Protoporphyria (EPP)

Sites in Boston +4 more locations

Sponsor: Portal Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT07567131·Recruiting·Listed May 2026

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Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia

for RPS19 Deficient Diamond-Blackfan Anemia

Sites in Boston +1 more location

Sponsor: Apriligen, Inc.

Sex: All·Age: 2 - 25

Code: NCT07476183·Phase 1·Recruiting·Listed Mar 2026

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The Short Sleep Study

for Short Sleepers

Sites in Boston +3 more locations

Sponsor: Danisco

Sex: All·Age: 20 - 50

Code: NCT07567560·Recruiting·Listed May 2026

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Phase 2/3 Clinical Study of QRX003 Lotion in Subjects With Netherton Syndrome

for Netherton Syndrome

Sites in Quincy +4 more locations

Sponsor: Quoin Pharmaceuticals

Sex: All·Age: 4+

Code: NCT07538583·Phase 2, Phase 3·Recruiting·Listed Apr 2026

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Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <4 Years With Rett Syndrome

for Rett Syndrome

1 location in Boston

Sponsor: Taysha Gene Therapies, Inc.

Sex: Female·Age: 2 - 3

Code: NCT07480564·Phase 3·Recruiting·Listed Mar 2026

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WEARABLE-BP: Wearable Everyday Automated Readings to Enable Assessment of Blood Pressure Control

for Hypertension (HTN)

1 location in Boston

Sponsor: Aktiia SA

Sex: All·Age: 21 - 85

Code: NCT07523269·Recruiting·Listed Apr 2026

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Multicenter Symphony™ IL-6 Monitoring Sepsis ED Pilot Study

for Sepsis, Septic Shock

Sites in Boston +4 more locations

Sponsor: Bluejay Diagnostics, Inc.

Sex: All·Age: 22+

Code: NCT07425587·Recruiting·Listed Feb 2026

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A Phase 1 Study of the Safety and Tolerability of CTX-10726

for Gastroesophageal Cancer (GC)

Drug: CTX-10726

Sites in Boston +5 more locations

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT07419841·Phase 1·Recruiting·Listed Feb 2026

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Investigation of the Delve Detect Cerebrospinal Fluid (CSF) Metagenomic Next-generation Sequencing (mNGS) Test When Used for the Initial Diagnostic Workup of Patients With Suspected Central Nervous System (CNS) Infection

for Central Nervous System Infection

Sites in Burlington +3 more locations

Sponsor: Delve Bio, Inc.

Sex: All·Age: All ages

Code: NCT07435649·Recruiting·Listed Feb 2026

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