Paid Clinical Trials in Massachusetts

Massachusetts has 3,446 paid clinical trials enrolling now across cities including Boston, Worcester and Burlington. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,953 clinical trials

This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

for Non Small Cell Lung Cancer

Sites in Boston +2 more locations

Sponsor: Zumutor Biologics Inc.

Sex: All·Age: 18+

Code: NCT06451497·Phase 1·Recruiting·Listed Jun 2024

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Boston +8 more locations

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting·Listed Dec 2020

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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

for Drug Resistant Epilepsy

Sites in Boston +2 more locations

Sponsor: NaviFUS Corporation

Sex: All·Age: 18+

Code: NCT06388707·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects

for Short Bowel Syndrome

Sites in Boston +1 more location

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18+

Code: NCT04775706·Phase 2·Recruiting·Listed Mar 2021

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A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

for Alpha 1-Antitrypsin Deficiency

Sites in Boston +2 more locations

Sponsor: Beam Therapeutics Inc.

Sex: All·Age: 18 - 70

Code: NCT06389877·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

for Prion Disease

Sites in Boston +2 more locations

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06153966·Phase 1, Phase 2·Recruiting·Listed Dec 2023

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Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +6 more locations

Sponsor: Tagworks Pharmaceuticals BV

Sex: All·Age: 18+

Code: NCT06959706·Phase 1·Recruiting·Listed May 2025

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A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

for VEXAS

Drug: Pacritinib

Sites in Boston +8 more locations

Sponsor: Swedish Orphan Biovitrum

Sex: All·Age: 18+

Code: NCT06782373·Phase 2·Recruiting·Listed Jan 2025

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ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)

for Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome

Sites in Boston +7 more locations

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: Male·Age: 2 - 65

Code: NCT06430385·Phase 1, Phase 2·Recruiting·Listed May 2024

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Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

for Locally Advanced Pancreatic Adenocarcinoma

Sites in Boston +6 more locations

Sponsor: EXACT Therapeutics AS

Sex: All·Age: 18+

Code: NCT06850623·Phase 2·Recruiting·Listed Feb 2025

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A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa

for Retinitis Pigmentosa

Sites in Boston +1 more location

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT06891885·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy

for Cytokine Release Syndrome

Sites in Boston +5 more locations

Sponsor: CytoAgents, Inc.

Sex: All·Age: 18+

Code: NCT05905328·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)

for Canavan Disease

Sites in Boston +2 more locations

Sponsor: Aspa Therapeutics

Sex: All·Age: Up to 30 Months

Code: NCT04998396·Phase 1, Phase 2·Recruiting·Listed Aug 2021

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Brain Stimulation for Severe Depression

for Depression Severe

Sites in Boston +1 more location

Sponsor: Inner Cosmos Inc

Sex: All·Age: 21 - 80

Code: NCT05393622·Recruiting·Listed May 2022

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Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer

for Prostate Cancer (Adenocarcinoma)

Sites in Boston +7 more locations

Sponsor: Acerand Therapeutics (Hong Kong) Limited

Sex: Male·Age: 18+

Code: NCT06801236·Phase 1·Recruiting·Listed Jan 2025

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Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

for Overactive Bladder

Sites in Watertown +8 more locations

Sponsor: InMode MD Ltd.

Sex: Female·Age: 22 - 80

Code: NCT07209397·Recruiting·Listed Oct 2025

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Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

Sites in Boston +7 more locations

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting·Listed Aug 2025

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Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Boston +5 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06419634·Phase 1·Recruiting·Listed May 2024

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease

for Tremor Associated With Tremor Dominant Parkinson's Disease

Sites in Boston +6 more locations

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT04991831·Recruiting·Listed Aug 2021

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Microbial Cell-free Metagenomic Sequencing for Suspected Infections in Adult Immunocompromised Outpatients

for Infection

Sites in Boston +5 more locations

Sponsor: Karius, Inc.

Sex: All·Age: 18+

Code: NCT07110636·Recruiting·Listed Aug 2025

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ARC101 in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +2 more locations

Sponsor: Third Arc Bio

Sex: All·Age: 18+

Code: NCT06672185·Phase 1·Recruiting·Listed Nov 2024

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Home-Based tDCS Treatment Of Major Depressive Disorder

for Major Depressive Disorder (MDD)

1 location in Boston

Sponsor: Sooma Medical Inc

Sex: All·Age: 22 - 70

Code: NCT06976697·Recruiting·Listed May 2025

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A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies

for Muscular Atrophy, Spinal

Sites in Boston +2 more locations

Sponsor: Biogen

Sex: Female·Age: 18 - 54

Code: NCT05789758·Recruiting·Listed Mar 2023

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +4 more locations

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa

for Dystrophic Epidermolysis Bullosa

Sites in Worcester +4 more locations

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 6 Months+

Code: NCT07016750·Phase 3·Recruiting·Listed Jun 2025

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Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software

for Chronic Pain

1 location in Cambridge

Sponsor: AugMend Health Inc.

Sex: All·Age: 18+

Code: NCT07336537·Recruiting·Listed Jan 2026

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A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

for Hypothalamic Obesity

Sites in Boston +7 more locations

Sponsor: Rhythm Pharmaceuticals, Inc.

Sex: All·Age: 4+

Code: NCT06760546·Phase 3·Recruiting·Listed Jan 2025

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A Study of YL242 in Subjects With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +6 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT07197827·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

for Melanoma (Skin Cancer)

Sites in Boston +8 more locations

Sponsor: Linnaeus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06624644·Phase 2, Phase 3·Recruiting·Listed Oct 2024

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PKP2-ACM Natural History Study

for Cardiomyopathies

Sites in Boston +1 more location

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06644742·Recruiting·Listed Oct 2024

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Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related Disease

for IgG4 Related Disease

Sites in Boston +1 more location

Sponsor: Acepodia Biotech, Inc.

Sex: All·Age: 18 - 75

Code: NCT07061938·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

for Sensorineural Hearing Loss, Bilateral

Sites in Boston +5 more locations

Sponsor: Akouos, Inc.

Sex: All·Age: All ages

Code: NCT05821959·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

for Chronic Myelomonocytic Leukemia

Sites in Boston +6 more locations

Sponsor: Solu Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06950034·Phase 1·Recruiting·Listed Apr 2025

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Night Owl Sleep Study: The Effect of Sleep on Fecal Microbiota

for Sleep

Sites in Boston +2 more locations

Sponsor: Danisco

Sex: All·Age: 20 - 40·Accepts healthy volunteers

Code: NCT07243574·Recruiting·Listed Nov 2025

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Supportive Care Intervention for Outpatient Stem Cell Transplant Patients

for Hematopoietic Stem Cell Transplantation

1 location in Boston

Sponsor: Victor Wang

Sex: All·Age: 19+

Code: NCT06564233·Recruiting·Listed Aug 2024

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +3 more locations

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting·Listed Dec 2023

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A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata

for Alopecia Areata (AA)

Sites in Boston +3 more locations

Sponsor: Aldena Therapeutics

Sex: All·Age: 18 - 55

Code: NCT06826196·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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JAG201 Gene Therapy Study in Children & Adults With SHANK3 Haploinsufficiency

for SHANK3 Haploinsufficiency

Sites in Boston +2 more locations

Sponsor: Jaguar Gene Therapy, LLC

Sex: All·Age: 2 - 9

Code: NCT06662188·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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Multicenter Symphony IL-6 Monitoring Sepsis ICU Validation Study

for Sepsis, Septic Shock

Sites in Boston +4 more locations

Sponsor: Bluejay Diagnostics, Inc.

Sex: All·Age: 22+

Code: NCT06654895·Recruiting·Listed Oct 2024

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A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

Sites in Boston +6 more locations

Sponsor: Bristol-Myers Squibb

Sex: Male·Age: 18+

Code: NCT06067841·Phase 1·Recruiting·Listed Oct 2023

Apply to this trial