Paid Clinical Trials in Massachusetts

Massachusetts has 3,593 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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3,593 clinical trials

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Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee

for Prosthetic-joint Infection

2 locations incl. Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18 - 90

Code: NCT06636669·Phase 4·Enrolling By Invitation

Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

2 locations incl. Boston

Sponsor: Nerviano Medical Sciences

Sex: All·Age: 18+

Code: NCT06931626·Phase 1·Recruiting

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

8 locations incl. Sacramento

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting

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ELISA in Relapsed/Refractory MM

for Relapsed Refractory Multiple Myeloma (RRMM)

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06832865·Phase 2·Recruiting

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A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

17 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06948318·Phase 3·Recruiting

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PPDTM CorEvitasTM Myasthenia Gravis (MG) Drug Safety and Effectiveness Registry

for Myasthenia Gravis

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07217509·Enrolling By Invitation

Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

for Bone Marrow Transplant Complications

2 locations incl. Miami

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06910969·Recruiting

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Efgartigimod for the Treatment of Acute Optic Neuritis

for Optic Neuritis

2 locations incl. Boston

Sponsor: Anastasia Vishnevetsky, MD, MPH

Sex: All·Age: 18+

Code: NCT06453694·Phase 2·Recruiting

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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for Advanced Solid Tumor

18 locations incl. Phoenix

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07070232·Phase 1, Phase 2·Recruiting

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Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies

for Developmental and Epileptic Encephalopathies

1 location in Boston

Sponsor: Heather Olson

Sex: All·Age: 0 Days - 9 Months

Code: NCT06700811·Phase 1·Recruiting

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

6 locations incl. Duarte

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting

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The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

for Aging

2 locations incl. Boston

Sponsor: Mayo Clinic

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06940037·Recruiting

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Real-world Experience on Using Nemolizumab in the Treatment of Moderate-to- Severe Prurigo Nodularis in Adults

for Prurigo Nodularis

Drug: Nemolizumab

39 locations incl. Birmingham

Sponsor: Galderma R&D

Sex: All·Age: 18+

Code: NCT06988618·Recruiting

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A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes

for Diabetes Mellitus, Type 1

109 locations incl. Cullman

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07076199·Phase 3·Recruiting

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A Novel Wrist Wearable Sensor System to Promote Hemiparetic Upper Extremity Use in Subacute Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 85

Code: NCT06797154·Recruiting

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A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism

for Primary Hyperaldosteronism

Drug: Baxdrostat

21 locations incl. Los Angeles

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07007793·Phase 3·Recruiting

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Building Connections

for Cancer Colorectal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT07091032·Recruiting

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Optical Coherence Tomography (OCT) Based Intraoral Scanner

for The Focus of the Study is to Evaluate the Efficacy of OCT in Scanning and Reconstructing General Tooth and Gum Anatomy

1 location in Somerville

Sponsor: Perceptive Technologies, Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07092592·Not Yet Recruiting

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

for Alzheimer's Disease

24 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT07094516·Phase 2·Recruiting

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A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

for Melanoma (Skin Cancer)

9 locations incl. Newport Beach

Sponsor: Linnaeus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06624644·Phase 2, Phase 3·Recruiting

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A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

for Prostate Cancer

Drug: Saruparib

42 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT06952803·Phase 3·Recruiting

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Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

for Chronic Graft Versus Host Disease

3 locations incl. Tampa

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT07011810·Phase 2·Recruiting

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A Study of LY4257496 in Participants With Cancer (OMNIRAY)

for Breast Neoplasms

16 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07114601·Phase 1·Recruiting

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Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation

for Atrial Fibrillation (AF)

1 location in Boston

Sponsor: China National Center for Cardiovascular Diseases

Sex: All·Age: 18+

Code: NCT06615596·EARLY_Phase 1·Recruiting

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Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

for X-Linked Chronic Granulomatous Disease

8 locations incl. Los Angeles

Sponsor: Ensoma

Sex: Male·Age: 3 Months+

Code: NCT06876363·Phase 1, Phase 2·Recruiting

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Accelerated TMS for Perinatal Depression

for Perinatal Depression

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 55

Code: NCT06968390·Recruiting

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Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR

for Proliferative Diabetic Retinopathy (PDR)

28 locations incl. Huntington Beach

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT06790784·Phase 3·Recruiting

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Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07079761·Phase 2·Recruiting

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A Study of Dotinurad Versus Allopurinol in Tophaceous Gout

for Tophaceous Gout

Drug: Dotinurad

86 locations incl. Birmingham

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07089888·Phase 3·Recruiting

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Understanding Vape Marketing Study

for E-cigarette

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 13+·Accepts healthy volunteers

Code: NCT07129265·Enrolling By Invitation

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting

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Modeling Blood Management and Hemolytic Risk in Pediatric Heart Surgery

for Heart Surgery

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 17

Code: NCT06721455·Recruiting

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Study Evaluating the Efficacy and Safety of Artesunate

for CMV Infection

2 locations incl. Boston

Sponsor: Amivas Inc.

Sex: All·Age: 18+

Code: NCT06853184·Phase 2·Recruiting

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A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

for Advanced Solid Tumor

15 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06997029·Phase 1·Recruiting

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Gamified Learning for Pressure Injury Prevention

for Pressure Injuries

1 location in Boston

Sponsor: Mehmet Akif Ersoy University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07028892·Not Yet Recruiting

Individualizing Treatment for Asthma in Primary Care (Full Study)

for Asthma

13 locations incl. Aurora

Sponsor: DARTNet Institute

Sex: All·Age: 13 - 75

Code: NCT07052942·Phase 4·Recruiting

Apply to this trial

A Study of Dotinurad Versus Allopurinol in Participants With Gout

for Gout

Drug: Dotinurad

80 locations incl. Birmingham

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07089875·Phase 3·Recruiting

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Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery

for Atrial Fibrillation

1 location in Melrose

Sponsor: Baystate Medical Center

Sex: All·Age: 18+

Code: NCT01422148·Phase 2·Not Yet Recruiting

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

10 locations incl. Duarte

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting

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CUE-102 in Recurrent Glioblastoma

for Recurrent Glioblastoma

2 locations incl. Boston

Sponsor: David Reardon, MD

Sex: All·Age: 18+

Code: NCT06917885·Phase 1·Recruiting

Apply to this trial