Paid Clinical Trials in Massachusetts

Massachusetts has 3,446 paid clinical trials enrolling now across cities including Boston, Worcester and Burlington. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,953 clinical trials

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

for Melanoma

Sites in Boston +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 17

Code: NCT02332668·Phase 1, Phase 2·Recruiting·Listed Jan 2015

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ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

for Hepatoblastoma

Sites in Boston +3 more locations

Sponsor: Eureka Therapeutics Inc.

Sex: All·Age: 1 - 21

Code: NCT04634357·Phase 1, Phase 2·Recruiting·Listed Nov 2020

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ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis

for X-linked Retinoschisis

Sites in Boston +17 more locations

Sponsor: Atsena Therapeutics Inc.

Sex: All·Age: 6+

Code: NCT05878860·Phase 3·Recruiting·Listed May 2023

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KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure

for Pediatric Intestinal Failure

Sites in Boston +7 more locations

Sponsor: SterileCare Inc.

Sex: All·Age: 4 Weeks - 18

Code: NCT05879835·Recruiting·Listed May 2023

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A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma in Relapse

Sites in Boston +6 more locations

Sponsor: Kelonia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07075185·Phase 1·Recruiting·Listed Jul 2025

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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sites in Boston +8 more locations

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting·Listed Jan 2024

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Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

for Amputation

Sites in Pittsfield +4 more locations

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT06908538·Recruiting·Listed Apr 2025

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Observational Study of THC Concentrations in Acute Cannabis-induced CNS Depression

for Acute Cannabis-induced CNS Depression

Sites in Worcester +2 more locations

Sponsor: Anebulo Pharmaceuticals

Sex: All·Age: All ages

Code: NCT06017622·Recruiting·Listed Aug 2023

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Direct to Patient Minimal Risk Biospecimen and Data Collection Research

for Healthy

1 location in Lexington

Sponsor: Joined Bio

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07128966·Recruiting·Listed Aug 2025

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Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for Biliary Tract Cancer

Sites in Boston +5 more locations

Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All·Age: 18+

Code: NCT06239194·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +6 more locations

Sponsor: Vaxiion Therapeutics

Sex: All·Age: 18+

Code: NCT05901285·Phase 1·Recruiting·Listed Jun 2023

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Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

for Neuromyelitis Optica Spectrum Disorder

Sites in Boston +5 more locations

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05966467·Recruiting·Listed Jul 2023

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A Clinical Trial Comparing 2x/Day for 30-minutes Use of the Emanate Perio PODS Post-SRP to a Control Group Post-SRP.

for Periodontitis (Stage 3)

Sites in Boston +8 more locations

Sponsor: McGuire Institute

Sex: All·Age: 30 - 75

Code: NCT06914596·Recruiting·Listed Apr 2025

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A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)

for Multiple System Atrophy

Drug: Foralumab

1 location in Boston

Sponsor: Tiziana Life Sciences LTD

Sex: All·Age: 30 - 85

Code: NCT06868628·Phase 2·Recruiting·Listed Mar 2025

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Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

for Breast Neoplasms

Sites in Boston +4 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06686394·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

for Breast Cancer

Sites in Boston +1 more location

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT05950945·Phase 3·Recruiting·Listed Jul 2023

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A Study of MGC028 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +6 more locations

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06723236·Phase 1·Recruiting·Listed Dec 2024

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IKS014 in Advanced Solid Tumors That Express HER2

for Breast Cancer

Sites in Boston +3 more locations

Sponsor: Iksuda Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT05872295·Phase 1·Recruiting·Listed May 2023

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LYL273 for Patients With Relapsed or Refractory mCRC

for Colorectal Cancer

Sites in Boston +3 more locations

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT05319314·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

for HR+/HER2-negative Breast Cancer

Sites in Boston +8 more locations

Sponsor: Totus Medicines

Sex: Female·Age: 18+

Code: NCT05683418·Phase 1·Recruiting·Listed Jan 2023

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Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients With Cystic Fibrosis

for Cystic Fibrosis

Sites in Boston +2 more locations

Sponsor: SpliSense Ltd.

Sex: All·Age: 18+

Code: NCT06429176·Phase 2·Recruiting·Listed May 2024

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A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

for Alzheimer Disease

Sites in Charlestown +5 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 50 - 85

Code: NCT06297590·Phase 1·Recruiting·Listed Mar 2024

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A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

for Danon Disease

Sites in Boston +2 more locations

Sponsor: Rocket Pharmaceuticals Inc.

Sex: Male·Age: 8+

Code: NCT06092034·Phase 2·Recruiting·Listed Oct 2023

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Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +3 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06167317·Phase 1·Recruiting·Listed Dec 2023

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HLA Demographics Study in Adults With Type 1 Diabetes

for Diabetes Mellitus, Type I

Sites in Boston +4 more locations

Sponsor: GentiBio, Inc

Sex: All·Age: 18 - 55

Code: NCT06860516·Recruiting·Listed Mar 2025

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A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for Huntington Disease

Sites in Boston +4 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 65

Code: NCT06826612·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

for Non Hodgkin Lymphoma

Sites in Boston +7 more locations

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 13+

Code: NCT04771572·Phase 1·Recruiting·Listed Feb 2021

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Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula

for End Stage Renal Disease

Sites in Boston +7 more locations

Sponsor: Laminate Medical Technologies

Sex: All·Age: 18 - 80

Code: NCT06516653·Recruiting·Listed Jul 2024

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Study Evaluating the Efficacy and Safety of Artesunate

for CMV Infection

Sites in Boston +1 more location

Sponsor: Amivas Inc.

Sex: All·Age: 18+

Code: NCT06853184·Phase 2·Recruiting·Listed Feb 2025

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mTBI Identification and Monitoring Through Retinal Scanning

for Brain Injuries, Traumatic

1 location in Boston

Sponsor: Rebiscan, Inc.

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06142435·Recruiting·Listed Nov 2023

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Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +3 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06532565·Phase 1·Recruiting·Listed Aug 2024

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A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas

for B-cell Non-Hodgkins Lymphoma (B-NHL)

Drug: Odronextamab

Sites in Boston +8 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05685173·Phase 1·Recruiting·Listed Jan 2023

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An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

for Periodontal Diseases

Sites in Acton +1 more location

Sponsor: Erchonia Corporation

Sex: All·Age: 22 - 75

Code: NCT06656325·Recruiting·Listed Oct 2024

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Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

for X-Linked Chronic Granulomatous Disease

Sites in Boston +7 more locations

Sponsor: Ensoma

Sex: Male·Age: 3 Months+

Code: NCT06876363·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

Sites in Boston +8 more locations

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting·Listed Oct 2023

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Gaucher Disease Outcome Survey (GOS)

for Gaucher Disease

1 location in Lexington

Sponsor: Shire

Sex: All·Age: All ages

Code: NCT03291223·Recruiting·Listed Sep 2017

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Shoulder Innovations Clinical Data Registry

for Shoulder Arthroplasty

Sites in Peabody +7 more locations

Sponsor: Shoulder Innovations

Sex: All·Age: 18+

Code: NCT06754150·Recruiting·Listed Dec 2024

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FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

for Breast Cancer

Sites in Boston +6 more locations

Sponsor: Regor Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05304962·Phase 1·Recruiting·Listed Mar 2022

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A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL

for CTCL

Sites in Boston +5 more locations

Sponsor: Prescient Therapeutics, Ltd.

Sex: All·Age: 18+

Code: NCT06854653·Phase 2·Recruiting·Listed Mar 2025

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Advanta VXT and Flixene PMCF Registry

for Peripheral Arterial Disease

1 location in Boston

Sponsor: Atrium Medical Corporation

Sex: All·Age: 18+

Code: NCT07161583·Recruiting·Listed Sep 2025

Apply to this trial