Paid Clinical Trials in Massachusetts

Massachusetts has 3,593 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

3,593 clinical trials

↓ Download CSV

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

for Knee Osteoarthristis

1 location in Cambridge

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 55

Code: NCT06686680·Recruiting

Apply to this trial

EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

for Lung Cancer

6 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06716580·Recruiting

Apply to this trial

Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

for Familial Hypercholesterolaemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06743659·Recruiting

Apply to this trial

ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

for Corneal Transplant Failure

12 locations incl. Irvine

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06753916·Phase 2·Recruiting

Apply to this trial

Pharmacologic Augmentation of TMS for Depression With D-serine

for Depression

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 80

Code: NCT06876129·Phase 1·Recruiting

Apply to this trial

Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI

for May-Thurner Syndrome

1 location in Worcester

Sponsor: Ningcheng Peter Li

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06888024·Recruiting

Apply to this trial

Tools for Reducing Inequity in Acute Leukemia (TRIAL): Beta Testing

for Acute Leukemia

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06907797·Recruiting

Apply to this trial

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

for Amputation

4 locations incl. Pittsfield

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT06908538·Recruiting

Apply to this trial

Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

for Atrial Fibrillation (AF)

6 locations incl. Hartford

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT06957366·Recruiting

Apply to this trial

Risk Informed Obesity Care Plan Pilot

for Childhood Obesity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 2 - 12

Code: NCT07028814·Enrolling By Invitation

Direct to Patient Minimal Risk Biospecimen and Data Collection Research

for Healthy

1 location in Lexington

Sponsor: Joined Bio

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07128966·Recruiting

Apply to this trial

Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Military Population: The Sentinel Study

for Cancer Diagnosis

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT06523868·Recruiting

Apply to this trial

A Study of PHST001 in Advanced Solid Tumors

for Advanced Solid Tumors

20 locations incl. Beverly Hills

Sponsor: Pheast Therapeutics

Sex: All·Age: 18+

Code: NCT06840886·Phase 1·Recruiting

Apply to this trial

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

10 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06911112·Phase 3·Recruiting

Apply to this trial

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for Non-Small Cell Lung Cancer

16 locations incl. Los Angeles

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06917079·Phase 1·Recruiting

Apply to this trial

Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds

for Nasolabial Folds

7 locations incl. Scottsdale

Sponsor: AQTIS Medical B.V.

Sex: All·Age: 22+

Code: NCT06984835·Recruiting

Apply to this trial

Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

for Exocrine Pancreatic Insufficiency (EPI)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06691893·Phase 3·Recruiting

Apply to this trial

A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL

for CTCL

6 locations incl. Duarte

Sponsor: Prescient Therapeutics, Ltd.

Sex: All·Age: 18+

Code: NCT06854653·Phase 2·Recruiting

Apply to this trial

Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)

for Chronic Pain

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 60

Code: NCT06903962·Recruiting

Apply to this trial

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

100 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting

Apply to this trial

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

177 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting

Apply to this trial

A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

32 locations incl. Birmingham

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting

Apply to this trial

Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers

for Pain

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 22+

Code: NCT06722014·Recruiting

Apply to this trial

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

85 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

Apply to this trial

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

60 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting

Apply to this trial

Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

for Advanced Solid Tumor

Drug: AI-081

19 locations incl. Birmingham

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06635785·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for HR+ Breast Cancer

14 locations incl. La Jolla

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07029399·Phase 1·Recruiting

Apply to this trial

Project EMPOWER-OCD

for Obsessive-Compulsive Disorder

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07158801·Recruiting

Apply to this trial

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

15 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting

Apply to this trial

A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata

for Alopecia Areata (AA)

4 locations incl. Thousand Oaks

Sponsor: Aldena Therapeutics

Sex: All·Age: 18 - 55

Code: NCT06826196·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

for Triple Negative Locally Advanced Non-resectable Breast Cancer

6 locations incl. Los Angeles

Sponsor: Marengo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06827613·Phase 1, Phase 2·Recruiting

Apply to this trial

ctDNA in Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06875609·Recruiting

Apply to this trial

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

for Refractory Solid Tumors

7 locations incl. Los Angeles

Sponsor: Theodore Laetsch

Sex: All·Age: 1 - 30

Code: NCT06721689·Phase 1, Phase 2·Recruiting

Apply to this trial

Chiropractic Care for Episodic Migraine

for Episodic Migraine

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06229834·Recruiting

Apply to this trial

Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

76 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting

Apply to this trial

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

for MTAP-deleted Solid Tumors

17 locations incl. Birmingham

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06914128·Phase 1, Phase 2·Recruiting

Apply to this trial

Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 85

Code: NCT05626894·Phase 2·Recruiting

Apply to this trial

A Randomized Phase 2 Trial of Nivolumab, Relatlimab Plus Ipilimumab vs. Nivolumab Plus Ipilimumab in First-line Advanced Renal Cell Carcinoma (RCC)

for Renal Cell Carcinoma, Clear Cell

Drug: Ipilimumab

6 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06708949·Phase 2·Recruiting

Apply to this trial

A Study of Navenibart in Participants With Hereditary Angioedema

for Hereditary Angioedema (HAE)

Drug: navenibart

19 locations incl. Birmingham

Sponsor: Astria Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT06842823·Phase 3·Enrolling By Invitation

Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea

for FHA (Functional Hypothalamic Amenorrhea)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 14 - 30

Code: NCT06533865·Phase 3·Recruiting

Apply to this trial