Paid Clinical Trials in Massachusetts

Massachusetts has 3,446 paid clinical trials enrolling now across cities including Boston, Worcester and Burlington. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,953 clinical trials

Assessment of Microvascular Circulation in the Pediatric Cardiac Surgery Patient

for Tetrology of Fallot

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT07184476·Recruiting·Listed Sep 2025

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

Sites in Boston +74 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting·Listed Oct 2023

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Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

for Cystic Fibrosis

Sites in Boston +34 more locations

Sponsor: Sonya Heltshe

Sex: All·Age: Up to 10

Code: NCT04509050·Recruiting·Listed Aug 2020

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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Hyde Park +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

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PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Boston +30 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting·Listed Sep 2024

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Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

Sites in Worcester, Burlington +379 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024

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Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

for Nicotine Dependence

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07145866·Phase 4·Recruiting·Listed Aug 2025

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ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

Sites in Boston, Burlington +44 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting·Listed May 2021

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in Burlington, Beverly +101 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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TIL Therapy in cSCC and MCC

for Cutaneous Squamous Cell Carcinoma

1 location in Boston

Sponsor: Karam Khaddour, MD, MS

Sex: All·Age: 18+

Code: NCT07288073·Phase 2·Recruiting·Listed Dec 2025

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BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention

for Colorectal Cancer Prevention

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT07162337·Recruiting·Listed Sep 2025

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in Boston +100 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Boston, Worcester +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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Adjuvant Chemotherapy and Immunotherapy for Completely Resected Small Cell Lung Cancer

for Small Cell Lung Cancer (SCLC)

Sites in Boston +2 more locations

Sponsor: Alliance Foundation Trials, LLC.

Sex: All·Age: 18+

Code: NCT07149363·Phase 2·Recruiting·Listed Sep 2025

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Boston +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Multi-Center Clean Air Randomized Controlled Trial in COPD

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Boston +10 more locations

Sponsor: JHSPH Center for Clinical Trials

Sex: All·Age: 40+

Code: NCT06376994·Phase 3·Recruiting·Listed Apr 2024

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

Sites in Boston +20 more locations

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for Anatomic Stage III Breast Cancer AJCC v8

Drug: Pidnarulex

Sites in Boston +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07137416·Phase 1·Recruiting·Listed Aug 2025

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Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

for Congenital Disorders of Glycosylation

Sites in Boston +11 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: All ages

Code: NCT04199000·Recruiting·Listed Dec 2019

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The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

Sites in Burlington +46 more locations

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting·Listed Jul 2023

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in Boston +90 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

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The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in Boston +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

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Piloting a Deaf Accessible Pre-Treatment for AUD

for Alcohol Use Disorder

1 location in Shrewsbury

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07269119·Recruiting·Listed Dec 2025

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Sites in Worcester +240 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting·Listed Sep 2023

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RA-PRO PRAGMATIC TRIAL

for Rheumatoid Arthritis

Sites in Boston, Worcester +46 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT04692493·Phase 3·Recruiting·Listed Dec 2020

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

Sites in Boston +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting·Listed Nov 2024

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Distal Radius Interventions for Fracture Treatment

for Fracture Distal Radius

Sites in Boston +23 more locations

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 10

Code: NCT05131685·Recruiting·Listed Nov 2021

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

Sites in Boston +96 more locations

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting·Listed Jul 2019

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Rett Syndrome Registry

for Rett Syndrome

Sites in Boston +18 more locations

Sponsor: International Rett Syndrome Foundation

Sex: All·Age: 0 - 99

Code: NCT05432349·Recruiting·Listed Jun 2022

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Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

for Cardiac Arrest, Out-Of-Hospital

Sites in Boston +46 more locations

Sponsor: University of Michigan

Sex: All·Age: 2 Days - 17

Code: NCT05376267·Recruiting·Listed May 2022

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Molecular Genetics Studies of Cancer Patients and Their Relatives

for Malignant Neoplasm

Sites in Brighton +34 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04185935·Recruiting·Listed Dec 2019

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Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

Sites in Boston +42 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting·Listed Jan 2023

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Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Controlled Giant Cell Arteritis

for Giant Cell Arteritis (GCA)

Drug: Tocilizumab

Sites in Boston +6 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 50+

Code: NCT07108387·Phase 2·Recruiting·Listed Aug 2025

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Burlington, Peabody +584 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting·Listed Oct 2018

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Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT

for Lack of Keratinized Gingiva

1 location in Boston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: 20 - 80·Accepts healthy volunteers

Code: NCT07440303·Recruiting·Listed Feb 2026

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A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

for Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

Sites in Boston +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07020533·Phase 1·Recruiting·Listed Jun 2025

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Project EMPOWER-OCD

for Obsessive-Compulsive Disorder

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07158801·Recruiting·Listed Sep 2025

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Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for Castration-Resistant Prostate Carcinoma

Sites in Springfield, Foxborough +100 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632977·Phase 2·Recruiting·Listed Oct 2024

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Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

for Clinical Stage I Esophageal Adenocarcinoma AJCC v8

Sites in Boston +64 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT03801876·Phase 3·Recruiting·Listed Jan 2019

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Teclistamab-Daratumumab in AL Amyloidosis

for Amyloid Light-chain Amyloidosis

Drug: Daratumumab

Sites in Boston +2 more locations

Sponsor: Rajshekhar Chakraborty, MD

Sex: All·Age: 18 - 100

Code: NCT07110844·Phase 2·Recruiting·Listed Aug 2025

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