Paid Clinical Trials in Massachusetts

Massachusetts has 3,593 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 18, 2026.

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3,602 clinical trials

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Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

for Extensive-stage Small-cell Lung Cancer

32 locations incl. Tucson

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06712355·Phase 3·Recruiting

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Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck

for Squamous Cell Carcinoma of Head and Neck

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06744296·Recruiting

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Predict the Best Level of Care Placement for Each Child's Behavioral Health Needs - Efficacy Study

for Adolescent Well-Being

1 location in Framingham

Sponsor: Outcome Referrals, Inc.

Sex: All·Age: All ages

Code: NCT06815562·Enrolling By Invitation

Predict the Best Level of Care Placement for Each Child's Behavioral Health Needs - Effectiveness Study

for Adolescent Well-Being

1 location in Framingham

Sponsor: Outcome Referrals, Inc.

Sex: All·Age: All ages

Code: NCT06834763·Enrolling By Invitation

Sensory Outcomes in Active Substance Users

for Post Operative Pain

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06639438·Recruiting

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Non-Invasive Preeclampsia Screening and Biobank

for Preeclampsia (PE)

21 locations incl. Glendale

Sponsor: Sequenom, Inc.

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06643741·Recruiting

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Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

for Depressive Disorder, Major

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05232032·Phase 2·Recruiting

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Study of Olutasidenib and Temozolomide in HGG

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 12 - 39

Code: NCT06161974·Phase 2·Recruiting

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Improving Mental Health Treatment for Individuals in Crisis Interacting With the Criminal-Legal System

for Suicide Risk

1 location in Cambridge

Sponsor: Cambridge Health Alliance

Sex: All·Age: 18 - 100

Code: NCT06564948·Recruiting

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Regulation of Emotion, Sleep Extension, and mTBI

for Mild Traumatic Brain Injury

1 location in North Andover

Sponsor: Merrimack College

Sex: All·Age: 18 - 35

Code: NCT06883006·Phase 1·Recruiting

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Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

for Breast Cancer Surgery

4 locations incl. New Haven

Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Sex: Female·Age: 18 - 90

Code: NCT06888388·Recruiting

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Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting

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Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

for Alzheimer Disease

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT05904132·Recruiting

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

41 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting

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Vaccine Confidence Study Among Historically Marginalized Racial and Ethnic Groups

for Vaccine Hesitancy

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06639386·Recruiting

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CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut Syndrome

for Lennox-Gastaut Syndrome (LGS)

1 location in Boston

Sponsor: Alexander Rotenberg

Sex: All·Age: 2 - 55

Code: NCT06738732·Phase 1, Phase 2·Not Yet Recruiting

Nemaline Myopathy Clinical Research Network (NM-CTRN)

for Nemaline Myopathy

5 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 0 - 18

Code: NCT06774703·Not Yet Recruiting

A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Elranatamab

2 locations incl. Boston

Sponsor: David Avigan

Sex: All·Age: 18+

Code: NCT06799026·Phase 1·Recruiting

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Study of hALK.CAR T Cells for Patients With Relapsed/Refractory High-risk Neuroblastoma

for Relapsed Neuroblastoma

2 locations incl. Boston

Sponsor: Roberto Chiarle

Sex: All·Age: 12 Months - 29

Code: NCT06803875·Phase 1, Phase 2·Recruiting

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Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

for Major Depressive Disorder

2 locations incl. Sunnyvale

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06376734·Phase 2·Recruiting

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Pilot of an Online Sexual Health Program

for Program, Communication

1 location in Wellesley

Sponsor: Wellesley College

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT06564025·Recruiting

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A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

for Chronic Lymphocytic Leukaemia

13 locations incl. Boston

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06564038·Phase 1, Phase 2·Recruiting

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Family Connections

for Emotional Disturbance

1 location in Cambridge

Sponsor: Cambridge Health Alliance

Sex: All·Age: 3 - 18

Code: NCT06662357·Recruiting

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FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

for Metastatic Head and Neck Squamous Cell Carcinoma

53 locations incl. Birmingham

Sponsor: Bicara Therapeutics

Sex: All·Age: 18+

Code: NCT06788990·Phase 2, Phase 3·Recruiting

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An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis

for Recurrent Pericarditis

17 locations incl. Tucson

Sponsor: Zomagen Biosciences Ltd.

Sex: All·Age: 18 - 75

Code: NCT06836232·Phase 2·Recruiting

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A Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors

for Sexual Dysfunction

3 locations incl. Coral Gables

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06541002·Recruiting

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Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

for Sarcoma

3 locations incl. Boston

Sponsor: David S Shulman, MD

Sex: All·Age: 12 - 49

Code: NCT06709495·Phase 1, Phase 2·Recruiting

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A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

for NonSegmental Vitiligo

Drug: Ruxolitinib

80 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 11

Code: NCT06548360·Phase 3·Recruiting

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Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

for Advanced or Metastatic Solid Tumors

5 locations incl. Boston

Sponsor: Innate Pharma

Sex: All·Age: 18+

Code: NCT06781983·Phase 1·Recruiting

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Diabetes Body Project 2

for Eating Disorders

1 location in Boston

Sponsor: Joslin Diabetes Center

Sex: Female·Age: 18 - 40

Code: NCT07468188·Recruiting

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Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

for Depressive Disorder, Major

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 25 - 50

Code: NCT06136546·Phase 2·Recruiting

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A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

6 locations incl. Tampa

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06697184·Phase 1, Phase 2·Recruiting

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Mindfulness for Cognition in Early-stage Alzheimer's Disease

for Mild Cognitive Impairment (MCI)

1 location in Boston

Sponsor: VA Boston Healthcare System

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT06792877·Recruiting

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Dance Study for Post-surgical Pain in Breast Cancer Survivors

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06758102·Recruiting

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Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

18 locations incl. Little Rock

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06786624·Phase 3·Recruiting

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Advanced Imaging for Pulmonary Fibrosis

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Peter Caravan

Sex: All·Age: 18 - 80

Code: NCT06532071·Phase 2·Recruiting

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Epco, Zanu, Ritux for R/R FL or MZL

for Follicular Lymphoma

3 locations incl. Boston

Sponsor: Reid Merryman, MD

Sex: All·Age: 18+

Code: NCT06563596·Phase 2·Recruiting

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A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

33 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting

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Transcranial Stimulation Combined With Auditory Training

for Difficulties Understanding Speech in Noise

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50+

Code: NCT06738030·Not Yet Recruiting

Synergy Between Patient and Clinician: Using a Trauma-Informed Care Plan

for Trauma and Stressor Related Disorders

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06330753·Enrolling By Invitation