Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

4 locations incl. Boston

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06167317·Phase 1·Recruiting

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CRICKET: Critical Events in Anaesthetised Kids Undergoing Tracheal Intubation

for Intubation Complication

2 locations incl. Boston

Sponsor: Thomas Riva

Sex: All·Age: Up to 16

Code: NCT05804188·Recruiting

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Pragmatic Trial to Increase Quality of Care in State Veterans Homes

for Long-Term Care

1 location in Bedford

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05906095·Enrolling By Invitation

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

for Breast Cancer

3 locations incl. Miami

Sponsor: Sarah Sammons, MD

Sex: All·Age: 18+

Code: NCT06176261·Phase 2·Recruiting

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JAG201 Gene Therapy Study in Children & Adults With SHANK3 Haploinsufficiency

for SHANK3 Haploinsufficiency

3 locations incl. Chicago

Sponsor: Jaguar Gene Therapy, LLC

Sex: All·Age: 2 - 9

Code: NCT06662188·Phase 1, Phase 2·Recruiting

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Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for Renal Cell Carcinoma

Drug: Nivolumab

6 locations incl. Irvine

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06053658·Phase 2·Recruiting

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A Global Study of the PETAL Consortium

for T-Cell and NK-Cell Neoplasm

10 locations incl. Duarte

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06067347·Recruiting

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PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

for Prion Disease

3 locations incl. Boston

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06153966·Phase 1, Phase 2·Recruiting

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A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

for Solid Tumors

Drug: INCB161734

16 locations incl. Phoenix

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06179160·Phase 1·Recruiting

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The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain

for COPD

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 40 - 100

Code: NCT05701982·Recruiting

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SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

for Chronic Kidney Diseases

28 locations incl. Bullhead City

Sponsor: VenoStent

Sex: All·Age: 18+

Code: NCT06001827·Recruiting

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Strength After Breast Cancer

for Breast Cancer

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: Female·Age: 18+

Code: NCT06052488·Recruiting

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Mechanisms Underlying the Efficacy of Prolonged Exposure

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: VA Boston Healthcare System

Sex: All·Age: 18 - 90

Code: NCT05663151·Recruiting

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Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial

for PROSTATE CANCER

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT06040125·Recruiting

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Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65

Code: NCT06109909·Recruiting

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Trazodone on OSA Endotypes

for Obstructive Sleep Apnea

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 70

Code: NCT06286189·Phase 1, Phase 2·Recruiting

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A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

for Essential Thrombocythemia

16 locations incl. Glendale

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06079879·Phase 3·Recruiting

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Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

for Breast Cancer

5 locations incl. Miami Beach

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT05950945·Phase 3·Recruiting

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Utilizing Battlefield Acupuncture to Treat Chronic Pain

for Chronic Pain

1 location in Bedford

Sponsor: Edith Nourse Rogers Memorial Veterans Hospital

Sex: All·Age: 18+

Code: NCT06128772·Recruiting

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A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

for Relapsed/Refractory Non-Hodgkin Lymphoma

14 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06090539·Phase 1, Phase 2·Recruiting

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Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy

for Cytokine Release Syndrome

6 locations incl. Orange

Sponsor: CytoAgents, Inc.

Sex: All·Age: 18+

Code: NCT05905328·Phase 1, Phase 2·Recruiting

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BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

for Hypertension

70 locations incl. Scottsdale

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT06059638·Recruiting

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A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

for Major Depressive Disorder

40 locations incl. Bellflower

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06223880·Phase 4·Recruiting

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting

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Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India

for Influenza

1 location in Boston

Sponsor: Boston University

Sex: Female·Age: 18 - 50

Code: NCT06168019·Recruiting

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Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors

for Melanoma

3 locations incl. New Haven

Sponsor: IO Biotech

Sex: All·Age: 18+

Code: NCT05280314·Phase 2·Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

90 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

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Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

for Cholangiocarcinoma

19 locations incl. Santa Monica

Sponsor: TransThera Sciences (Nanjing), Inc.

Sex: All·Age: 18+

Code: NCT05948475·Phase 3·Recruiting

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Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation

for Alzheimer Disease

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT06094192·Recruiting

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Global Trial in APG2575 for Patients With CLL/SLL

for CLL/SLL

11 locations incl. Tuscon

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 99

Code: NCT06104566·Phase 3·Recruiting

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Study of REM-422 in Patients With Recurrent, Metastatic, or Unresectable Adenoid Cystic Carcinoma

for Adenoid Cystic Carcinoma

6 locations incl. San Francisco

Sponsor: Remix Therapeutics

Sex: All·Age: 18+

Code: NCT06118086·Phase 1, Phase 2·Recruiting

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RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

for Idiopathic Inflammatory Myopathy

31 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 6 - 75

Code: NCT06154252·Phase 2, Phase 3·Recruiting

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Contraceptive Efficacy Study of Ovaprene

for Contraception

27 locations incl. Phoenix

Sponsor: Daré Bioscience, Inc.

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06127199·Recruiting

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Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.

for Crohn Disease

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 99

Code: NCT06252493·Recruiting

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A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies

for Muscular Atrophy, Spinal

4 locations incl. Palo Alto

Sponsor: Biogen

Sex: Female·Age: 18 - 54

Code: NCT05789758·Recruiting

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Beacon Sensors and Telerehabilitation to Assess and Improve Use of Devices (BeST-AID) for Low Vision

for Low Vision

9 locations incl. Fullerton

Sponsor: University of California, Los Angeles

Sex: All·Age: 18+

Code: NCT06107881·Recruiting

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Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

for Non-small Cell Lung Cancer (NSCLC)

15 locations incl. Phoenix

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06170788·Phase 3·Recruiting

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ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer

for Prostate Cancer

4 locations incl. San Diego

Sponsor: University of California, San Diego

Sex: Male·Age: 18+

Code: NCT06579417·Recruiting

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Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

388 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting

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Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

for Atrial Fibrillation

6 locations incl. Jonesboro

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06099730·Recruiting

Apply to this trial