Paid Clinical Trials in Minnesota

Minnesota has 2,230 paid clinical trials enrolling now across cities including Rochester, Minneapolis and Saint Paul. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Minnesota include Mayo Clinic and University of Minnesota Medical Center, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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1,932 clinical trials

ECD-Score: a Study on Erdheim-Chester Disease

for Erdheim-Chester Disease (ECD)

Sites in Rochester +2 more locations

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 7+

Code: NCT07454343·Recruiting·Listed Mar 2026

Apply to this trial

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07401771·Recruiting·Listed Feb 2026

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Impact of Physician Behavior on Cancer Distress

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07325006·Recruiting·Listed Jan 2026

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A Study Of Milk Consumption In Metabolic Syndrome

for Metabolic Syndrome

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT07401888·Recruiting·Listed Feb 2026

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A Pilot Study of a Portable Head-Only MRI Scanner

for Brain Imaging

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07444034·Recruiting·Listed Mar 2026

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A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound

for Heart Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 15+

Code: NCT07351656·Recruiting·Listed Jan 2026

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A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

for Cardiovascular Diseases

Sites in Minneapolis +4 more locations

Sponsor: Fundación EPIC

Sex: All·Age: 18 - 85

Code: NCT07286578·Recruiting·Listed Dec 2025

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Axelopran for Advanced Cancer in Patients Receiving Opioids

for Breast Cancer

Sites in Saint Paul & Saint Louis Park

Sponsor: HealthPartners Institute

Sex: All·Age: 18+

Code: NCT07354919·Phase 2·Recruiting·Listed Jan 2026

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Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04)

for Cervical Carcinoma

Sites in Minneapolis +17 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 25+·Accepts healthy volunteers

Code: NCT07281430·Recruiting·Listed Dec 2025

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A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Sites in Rochester +8 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07428044·Phase 2·Recruiting·Listed Feb 2026

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PASCAL Feasibility Study

for Smoking Cessation

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 21+

Code: NCT07301151·Recruiting·Listed Dec 2025

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A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects

for Exocrine Pancreatic Insufficiency

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07285863·Phase 4·Recruiting·Listed Dec 2025

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Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury

for Spinal Cord Injury

1 location in Saint Paul

Sponsor: HealthPartners Institute

Sex: All·Age: 18 - 84

Code: NCT07384052·Phase 1·Recruiting·Listed Feb 2026

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Enhancing Brain And Mental Health Through Breathing Practice

for Depressive Disorder

Sites in Albert Lea +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 12 - 17

Code: NCT07369752·Recruiting·Listed Jan 2026

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A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT07291011·Recruiting·Listed Dec 2025

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Alternate Nostril Breathing (ANB) for 1st Trimester Nausea and Vomiting

for Pregnancy Emesis

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: Female·Age: 18+

Code: NCT07378839·Recruiting·Listed Jan 2026

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24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

for Open Angle Glaucoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07325240·Phase 4·Recruiting·Listed Jan 2026

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for Advanced Endometrial Carcinoma

Drug: Bevacizumab

Sites in Minneapolis, Saint Paul +235 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07198074·Phase 3·Recruiting·Listed Sep 2025

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Screening and Staging of Benign vs Malignant Pelvic Abnormalities

for Endometrial Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07407959·Recruiting·Listed Feb 2026

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Itraconazole Therapy In Bronchiectasis With Airway Mold

for Bronchiectasis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07283497·Phase 4·Recruiting·Listed Dec 2025

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Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

for Metastatic Castration-Resistant Prostate Carcinoma

Sites in Saint Cloud +61 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: Male·Age: 18+

Code: NCT07200830·Phase 3·Recruiting·Listed Oct 2025

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Family Communications After Genetic Testing

for Colon Adenocarcinoma

Sites in Minneapolis, Saint Paul +273 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07143487·Recruiting·Listed Aug 2025

Apply to this trial

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

for Unipolar Depression

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT07266545·Phase 4·Recruiting·Listed Dec 2025

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Minneapolis, Saint Paul +633 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

A Standardized Counseling Approach to Preoperative Education in Transmasculine Individuals Receiving Gender-affirming Surgery

for Hysterectomy

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07324967·Recruiting·Listed Jan 2026

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Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

for Respiratory Distress Syndrome, Newborn

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 32 Weeks - 41 Weeks·Accepts healthy volunteers

Code: NCT07344714·Recruiting·Listed Jan 2026

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A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation

for Cardiomyopathy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07308704·Recruiting·Listed Dec 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Rochester, Minneapolis +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

Sites in Minneapolis, Saint Paul +277 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting·Listed Jul 2025

Apply to this trial

Voices: Messages of Wisdom and Hope in the Face of Illness

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07381179·Recruiting·Listed Feb 2026

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Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

for Advanced Hepatocellular Carcinoma

Sites in Duluth, Deer River +136 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07166406·Phase 3·Recruiting·Listed Sep 2025

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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Minneapolis, Saint Paul +920 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

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A Screening Program to Improve the Early Detection of Sporadic Pancreatic Cancer in Individuals With a High-Risk of Developing Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50 - 85

Code: NCT07324096·Recruiting·Listed Jan 2026

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Effect of Vibro-tactile Stimulation Intensity on Head Posture in Cervical Dystonia

for Cervical Dystonia

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT07245615·Recruiting·Listed Nov 2025

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

Sites in Rochester, Minneapolis +774 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in Minneapolis, Saint Louis Park +296 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

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Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

for Intracranial Meningioma

Sites in Minneapolis, Saint Paul +454 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

Sites in Duluth, Deer River +294 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

for Head and Neck Squamous Cell Carcinoma

Sites in Minneapolis, Saint Paul +464 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016

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ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Rochester, Minneapolis +583 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial