Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

for Geographic Atrophy

Sites in Durham +14 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 50+

Code: NCT05626114·Phase 2·Recruiting·Listed Nov 2022

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A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN)

for Primary Membranous Nephropathy

Sites in Greenville +14 more locations

Sponsor: Biogen

Sex: All·Age: 18 - 80

Code: NCT06962800·Phase 3·Recruiting·Listed May 2025

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Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

for Chronic Low-back Pain

Sites in Bermuda Run +18 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06827262·Recruiting·Listed Feb 2025

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CoMind Early Feasibility Study

for Intracranial Pressure

Sites in Raleigh +11 more locations

Sponsor: CoMind Technologies Limited

Sex: All·Age: 18+

Code: NCT06368648·Recruiting·Listed Apr 2024

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REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome

for Angelman Syndrome

Sites in Carrboro +17 more locations

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 50

Code: NCT06914609·Phase 3·Recruiting·Listed Apr 2025

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Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

for Generalized Myasthenia Gravis

Sites in Chapel Hill, Winston-Salem +17 more locations

Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Sex: All·Age: 18+

Code: NCT06463587·Phase 3·Recruiting·Listed Jun 2024

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Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

for Schizophrenia

Drug: KarXT

Sites in Kinston, Rose Hill +15 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07101094·Recruiting·Listed Aug 2025

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RevCore for In Stent Thrombosis

for In-stent Thrombosis

Sites in Asheville +15 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06394739·Recruiting·Listed May 2024

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The ArtixASCEND Study

for Acute Lower Limb Arterial Occlusion

Sites in Asheville +19 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT07135895·Recruiting·Listed Aug 2025

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A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

for Thrombocytopenia, Neonatal Alloimmune

Drug: Nipocalimab

Sites in Chapel Hill +11 more locations

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT06533098·Phase 3·Recruiting·Listed Aug 2024

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A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer

for Prostatic Neoplasms

Sites in Charlotte +11 more locations

Sponsor: Janssen Research & Development, LLC

Sex: Male·Age: 18+

Code: NCT06095089·Phase 1·Recruiting·Listed Oct 2023

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

Sites in Chapel Hill +17 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

Sites in Winston-Salem, Charlotte +18 more locations

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025

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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

Sites in Durham +9 more locations

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting·Listed Jul 2025

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A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

for Idiopathic Pulmonary Fibrosis

Drug: BI 765423

Sites in Durham +5 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07036523·Phase 2·Recruiting·Listed Jun 2025

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

Sites in Durham, Charlotte +17 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting·Listed Aug 2025

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Pivotal Study of the Velocity™ pAVF System

for Chronic Kidney Disease

Sites in Charlotte +12 more locations

Sponsor: Venova Medical

Sex: All·Age: 18 - 80

Code: NCT07153939·Recruiting·Listed Sep 2025

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PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

for Aneurysm

Sites in Durham, Greenville +8 more locations

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04545502·Recruiting·Listed Sep 2020

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A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

for Diffuse Large B-cell Lymphoma (DLBCL)

Drug: Odronextamab

Sites in Durham, Greenville +18 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091865·Phase 3·Recruiting·Listed Oct 2023

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A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

for Sickle Cell Disease

Sites in Winston-Salem, Greenville +14 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06439082·Phase 3·Recruiting·Listed Jun 2024

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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

Sites in Charlotte +16 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting·Listed Sep 2024

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A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for Anemia, Sickle Cell

Sites in Greenville +17 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06481306·Phase 1, Phase 2·Recruiting·Listed Jul 2024

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A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma

Sites in Durham, Charlotte +15 more locations

Sponsor: K36 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05651932·Phase 1·Recruiting·Listed Dec 2022

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

Sites in Durham +19 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting·Listed Jun 2025

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A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

for Uncontrolled Hypertension

Sites in Charlotte, Monroe +22 more locations

Sponsor: Retension Pharmaceuticals. Inc.

Sex: All·Age: 18 - 70

Code: NCT07142356·Phase 2·Recruiting·Listed Aug 2025

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Study of ORIC-944 in Patients With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

Sites in Charlotte +19 more locations

Sponsor: ORIC Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05413421·Phase 1·Recruiting·Listed Jun 2022

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Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

for Sickle Cell Disease Vaso-occlusive Crisis

Sites in Greenville +18 more locations

Sponsor: CSL Behring

Sex: All·Age: 12+

Code: NCT06699849·Phase 2·Recruiting·Listed Nov 2024

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A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

for mCRPC (Metastatic Castration-resistant Prostate Cancer)

Sites in Durham +18 more locations

Sponsor: Pathos AI, Inc.

Sex: Male·Age: 18+

Code: NCT06785636·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

for Multiple Myeloma

Sites in Chapel Hill, Winston-Salem +10 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06953960·Phase 1, Phase 2·Recruiting·Listed May 2025

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A Study of GNTI-122 in Adults Recently Diagnosed With T1D

for Type 1 Diabetes (T1D)

Sites in Durham, Chapel Hill +8 more locations

Sponsor: GentiBio, Inc

Sex: All·Age: 18 - 55

Code: NCT06919354·Phase 1·Recruiting·Listed Apr 2025

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A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

Sites in Chapel Hill, Fayetteville +20 more locations

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184944·Phase 3·Recruiting·Listed Sep 2025

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Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Pinehurst, Wilson +23 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06899126·Phase 3·Recruiting·Listed Mar 2025

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Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

for Advanced Solid Tumor

Sites in Huntersville +10 more locations

Sponsor: Aulos Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT05267626·Phase 1, Phase 2·Recruiting·Listed Mar 2022

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Fertilo In Vitro Research Study and Trial

for In Vitro Maturation of Oocytes

Sites in Charlotte, Raleigh +13 more locations

Sponsor: Gameto, Inc.

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06858111·Phase 3·Recruiting·Listed Mar 2025

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A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

Sites in Durham, Greenville +22 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06722235·Phase 3·Recruiting·Listed Dec 2024

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A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

for Locally Advanced Solid Tumors

Drug: Repotrectinib

Sites in Charlotte +11 more locations

Sponsor: Turning Point Therapeutics, Inc.

Sex: All·Age: Up to 25

Code: NCT04094610·Phase 1, Phase 2·Recruiting·Listed Sep 2019

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

Sites in Durham +16 more locations

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

for Platinum-resistant Ovarian Cancer

Sites in Durham +9 more locations

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06515613·Phase 1·Recruiting·Listed Jul 2024

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A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

for Solid Tumor

Sites in Hickory +10 more locations

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06952010·Phase 1·Recruiting·Listed Apr 2025

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A Study of TYRA-300 in Children With Achondroplasia: BEACH301

for Achondroplasia

Sites in Durham +11 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 3 - 10

Code: NCT06842355·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial