Paid Clinical Trials in North Carolina

North Carolina has 2,812 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,435 clinical trials

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

for Obstructive Sleep Apnea

Sites in Monroe +12 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07226765·Phase 3·Recruiting·Listed Nov 2025

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Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food Allergy

for Ig-E Mediated Food Allergy

Drug: RPT904

Sites in Chapel Hill +21 more locations

Sponsor: RAPT Therapeutics, Inc.

Sex: All·Age: 12 - 55

Code: NCT07220811·Phase 2·Recruiting·Listed Oct 2025

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A Gaucher Disease Gene Therapy Trial With FLT201

for Gaucher Disease Type 1

Sites in Durham +15 more locations

Sponsor: Spur Therapeutics

Sex: All·Age: 18+

Code: NCT07223944·Phase 3·Recruiting·Listed Nov 2025

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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

for Ovarian Neoplasms

Sites in Durham +19 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213791·Phase 1·Recruiting·Listed Oct 2025

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Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair

for Ventral Hernia

Sites in Wilmington +10 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 80

Code: NCT07226791·Phase 2·Recruiting·Listed Nov 2025

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A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

for Solid Tumors Harboring MET Amplification

Sites in Durham +16 more locations

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT07196644·Phase 2·Recruiting·Listed Sep 2025

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Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

Sites in Winston-Salem, Raleigh +10 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07217587·Phase 3·Recruiting·Listed Oct 2025

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A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation

for Microvascular Inflammation

Sites in Durham +20 more locations

Sponsor: Biogen

Sex: All·Age: 18 - 74

Code: NCT07219043·Phase 2·Recruiting·Listed Oct 2025

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

Sites in Durham +22 more locations

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting·Listed Oct 2025

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A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

for Cytomegalovirus Prophylaxis

Sites in Durham, Charlotte +16 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: Up to 17

Code: NCT07199465·Phase 1·Recruiting·Listed Sep 2025

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A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

for Nausea

Sites in Charlotte, Huntersville +18 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07169851·Phase 2·Recruiting·Listed Sep 2025

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A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

Sites in Chapel Hill, Fayetteville +20 more locations

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184944·Phase 3·Recruiting·Listed Sep 2025

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GORE® TAG® Thoracic Branch Endoprosthesis Zone 0/1 Post-Approval Study

for Aortic Arch Dissection

Sites in Durham, Chapel Hill +11 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT07166133·Recruiting·Listed Sep 2025

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A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

for Breast Cancer

Drug: Giredestrant

Sites in Charlotte +19 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT07100106·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

for Prosthetic-joint Infection

Sites in Leland +12 more locations

Sponsor: Peptilogics

Sex: All·Age: 18 - 80

Code: NCT07214311·Phase 2, Phase 3·Recruiting·Listed Oct 2025

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Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

for Complex Regional Pain Syndrome Type I

Sites in Winston-Salem, Charlotte +17 more locations

Sponsor: Ambros Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07210515·Phase 3·Recruiting·Listed Oct 2025

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IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

for Relapsed/Refractory Primary Central Nervous System Lymphoma

Drug: Rituximab

Sites in Durham +21 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT07104032·Phase 3·Recruiting·Listed Aug 2025

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A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

for Relapsed or Refractory Multiple Myeloma

Sites in Charlotte +9 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18+

Code: NCT07116616·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

for Clonal Mast Cell Disease

Sites in Chapel Hill +18 more locations

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07143669·Recruiting·Listed Aug 2025

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A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

Sites in Charlotte +21 more locations

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT07196501·Phase 3·Recruiting·Listed Sep 2025

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A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

for Colorectal Cancer

Sites in Durham +21 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07023289·Phase 2·Recruiting·Listed Jun 2025

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

Sites in Durham, Charlotte +17 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting·Listed Aug 2025

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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder

for Bipolar 1 Disorder

Sites in Charlotte +15 more locations

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 65

Code: NCT07046494·Phase 2·Recruiting·Listed Jul 2025

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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for Advanced Solid Tumor

Sites in Durham +17 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07070232·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant

for Multiple Myeloma

Drug: Daratumumab

Sites in Chapel Hill +16 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07095452·Phase 2, Phase 3·Recruiting·Listed Jul 2025

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SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

for Type 1 Diabetes

Sites in Chapel Hill, Asheville +21 more locations

Sponsor: SAb Biotherapeutics, Inc.

Sex: All·Age: 5 - 40

Code: NCT07187531·Phase 2·Recruiting·Listed Sep 2025

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A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

for Extensive-Stage Small Cell Lung Cancer

Drug: Atezolizumab

Sites in Durham +17 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06646276·Phase 3·Recruiting·Listed Oct 2024

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

Sites in Winston-Salem, Charlotte +18 more locations

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025

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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

Sites in Durham +9 more locations

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting·Listed Jul 2025

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The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms

for Hemorrhagic Stroke

Sites in Greenville +20 more locations

Sponsor: phenox Inc.

Sex: All·Age: 18+

Code: NCT07143019·Recruiting·Listed Aug 2025

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A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

for Solid Tumor

Sites in Hickory +10 more locations

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06952010·Phase 1·Recruiting·Listed Apr 2025

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A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

for Eosinophilic Esophagitis (EoE)

Drug: Dupilumab

Sites in Chapel Hill +10 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 6 Months - 6

Code: NCT07112378·Phase 3·Recruiting·Listed Aug 2025

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The ArtixASCEND Study

for Acute Lower Limb Arterial Occlusion

Sites in Asheville +16 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT07135895·Recruiting·Listed Aug 2025

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

Sites in Durham +19 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting·Listed Jun 2025

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A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

for Alzheimer's Disease

Sites in Chapel Hill +23 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT07094516·Phase 2·Recruiting·Listed Jul 2025

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Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for Non-small Cell Lung Cancer

Sites in Durham, Charlotte +20 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06765109·Phase 3·Recruiting·Listed Jan 2025

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Study of ORIC-944 in Patients With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

Sites in Charlotte +19 more locations

Sponsor: ORIC Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05413421·Phase 1·Recruiting·Listed Jun 2022

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Pivotal Study of the Velocity™ pAVF System

for Chronic Kidney Disease

Sites in Charlotte +11 more locations

Sponsor: Venova Medical

Sex: All·Age: 18 - 80

Code: NCT07153939·Recruiting·Listed Sep 2025

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Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

for Epilepsy

Sites in Durham, Charlotte +14 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110454·Recruiting·Listed Aug 2025

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Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

for Schizophrenia

Drug: KarXT

Sites in Kinston, Rose Hill +15 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07101094·Recruiting·Listed Aug 2025

Apply to this trial