Paid Clinical Trials in North Carolina

North Carolina has 2,939 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,939 clinical trials

↓ Download CSV

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

for Metastatic Castration Sensitive Prostate Cancer (mCSPC)

Drug: Mevrometostat

120 locations incl. Huntsville

Sponsor: Pfizer

Sex: Male·Age: 18+

Code: NCT07028853·Phase 3·Recruiting

Apply to this trial

Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

for Smoke Exposure

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT06841913·Phase 4·Recruiting

Apply to this trial

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for Acute Myeloid Leukemia (AML)

42 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07007312·Phase 3·Recruiting

Apply to this trial

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

for Urothelial Cancer

38 locations incl. Fullerton

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07129993·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza

for Influenza

120 locations incl. Anniston

Sponsor: Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Sex: All·Age: 12+

Code: NCT07159763·Phase 3·Recruiting

Apply to this trial

Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).

for Juvenile Psoriatic Arthritis

Drug: Secukinumab

8 locations incl. Gainesville

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 2 - 17

Code: NCT06751238·Phase 1·Recruiting

Apply to this trial

Healthy Living Anson Study

for Obesity (Disorder)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07126587·Recruiting

Apply to this trial

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

for Breast Cancer

14 locations incl. Orlando

Sponsor: Terremoto Biosciences Inc.

Sex: All·Age: 18+

Code: NCT07109726·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of PHN-012 in Patients With Advanced Solid Tumors

for Colon Cancer

11 locations incl. Los Angeles

Sponsor: Pheon Therapeutics

Sex: All·Age: 18+

Code: NCT07127874·Phase 1·Recruiting

Apply to this trial

Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke

for Acute Ischemic Stroke

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06781385·Phase 2·Enrolling By Invitation

GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

16 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting

Apply to this trial

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

for Chronic Obstructive Pulmonary Disease

Drug: Dupilumab

10 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 40 - 85

Code: NCT07053423·Phase 4·Recruiting

Apply to this trial

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

for Schizophrenia

Drug: KarXT

18 locations incl. Orange

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07101094·Recruiting

Apply to this trial

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

for Plaque Psoriasis

Drug: Deucravacitinib

122 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40+

Code: NCT07116967·Phase 3·Recruiting

Apply to this trial

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

for High Risk Cardiovascular Disease

Drug: Zilebesiran

257 locations incl. Birmingham

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07181109·Phase 3·Recruiting

Apply to this trial

Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder

for Social Anxiety Disorder (SAD)

30 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07221578·Phase 3·Recruiting

Apply to this trial

Affect-based Impulsivity in Borderline Personality Disorder

for Borderline Personality Disorder (BPD)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06880640·Recruiting

Apply to this trial

Pilot of Continuous Glucose Monitor-Augmented Food Is Medicine

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07148713·Recruiting

Apply to this trial

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

for Cystic Fibrosis (CF)

18 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 12+

Code: NCT06837181·Recruiting

Apply to this trial

Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI)

for ADHD

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 13 - 17·Accepts healthy volunteers

Code: NCT07089745·Recruiting

Apply to this trial

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

17 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000·Recruiting

Apply to this trial

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

652 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting

Apply to this trial

MAPS PrEP Van Study

for HIV Infection

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06908252·Phase 4·Recruiting

Apply to this trial

Repurposing Tilmanocept for Cardiac Sarcoidosis

for Cardiac Sarcoidosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07159074·Phase 2·Recruiting

Apply to this trial

A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

for Alzheimers Disease

Drug: Trontinemab

35 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 90

Code: NCT07169578·Phase 3·Recruiting

Apply to this trial

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

for Chronic Obstructive Pulmonary Disease

Drug: Lunsekimig

54 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 40 - 80

Code: NCT07190222·Phase 3·Recruiting

Apply to this trial

Use of fenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Uncontrolled Asthma Subjects and Controlled Asthma Subjects

for Asthma

13 locations incl. Stockton

Sponsor: Biometry Inc

Sex: All·Age: 5 - 100

Code: NCT07228026·Recruiting

Apply to this trial

Improving Needs Among Older Adults

for Critical Illness

4 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06588556·Recruiting

Apply to this trial

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

for Chronic Obstructive Pulmonary Disease

Drug: Lunsekimig

66 locations incl. Chandler

Sponsor: Sanofi

Sex: All·Age: 40 - 80

Code: NCT07190209·Phase 3·Recruiting

Apply to this trial

Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1

for Transtibial Amputation

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 75

Code: NCT07216183·Phase 1·Recruiting

Apply to this trial

A Skin Image Reference Tool to Aid Healthcare Providers' Diagnosis

for Dermatologic Disease

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 10+

Code: NCT07033169·Recruiting

Apply to this trial

A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

for Spinal Muscular Atrophy

Drug: Apitegromab

14 locations incl. Phoenix

Sponsor: Scholar Rock, Inc.

Sex: All·Age: Up to 2

Code: NCT07047144·Phase 2·Recruiting

Apply to this trial

A Web-Based Tool to Help People With Health Conditions Make Contraceptive Decisions

for Contraceptive Usage

18 locations incl. Phoenix

Sponsor: University of Michigan

Sex: Female·Age: 18 - 49

Code: NCT07075536·Enrolling By Invitation

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

for Hypertension

28 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07090161·Phase 2·Recruiting

Apply to this trial

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

for Osteoarthritis

Drug: Orforglipron

26 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07153471·Phase 3·Recruiting

Apply to this trial

Intent of Surgery for IPMN

for Intraductal Papillary Mucinous Neoplasm

8 locations incl. Phoenix

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07216521·Recruiting

Apply to this trial

A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

for Interstitial Lung Diseases

Drug: Nerandomilast

33 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06806592·Phase 3·Recruiting

Apply to this trial

A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO

for Neovascular Age-Related Macular Degeneration (NVAMD)

49 locations incl. Scottsdale

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 18+

Code: NCT07205887·Phase 2·Recruiting

Apply to this trial

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

for Breast Neoplasms

46 locations incl. Hot Springs

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06926868·Phase 2, Phase 3·Recruiting

Apply to this trial

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

for Anterior Cruciate Ligament Injuries

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 14 - 39

Code: NCT06942754·Recruiting

Apply to this trial