Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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A Global Prospective Observational Registry of Patients With Pompe Disease

for Pompe Disease

Sites in Durham +14 more locations

Sponsor: Amicus Therapeutics

Sex: All·Age: All ages

Code: NCT06121011·Recruiting·Listed Nov 2023

Apply to this trial

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

for Chronic Lymphocytic Leukemia

Sites in Durham +19 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876649·Phase 4·Recruiting·Listed Mar 2025

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A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

for Chronic Lymphocytic Leukemia

Sites in Durham +15 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876662·Phase 4·Recruiting·Listed Mar 2025

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A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

for Prostate Cancer

Sites in Durham +13 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: Male·Age: 18+

Code: NCT04729114·Phase 1·Recruiting·Listed Jan 2021

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A Study to Assess the Safety and Effectiveness of the UrOActive® Artificial Urinary sPHincter (AUS)

for Stress Urinary Incontinence (SUI)

Sites in Durham, Charlotte +11 more locations

Sponsor: UroMems SAS

Sex: Male·Age: 22+

Code: NCT06968741·Recruiting·Listed May 2025

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Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

for Heart Failure With Preserved Ejection Fraction (HFpEF

Sites in Durham +12 more locations

Sponsor: Axon Therapies, Inc.

Sex: All·Age: 40+

Code: NCT04592445·Recruiting·Listed Oct 2020

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Pompe Pregnancy Sub-Registry

for Glycogen Storage Disease Type II (GSD-II)

Sites in Durham +13 more locations

Sponsor: Genzyme, a Sanofi Company

Sex: Female·Age: All ages

Code: NCT00567073·Recruiting·Listed Dec 2007

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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

for Hypoxic-Ischemic Encephalopathy

Sites in Durham +13 more locations

Sponsor: ReAlta Life Sciences, Inc.

Sex: All·Age: Up to 10 Hours

Code: NCT05778188·Phase 2·Recruiting·Listed Mar 2023

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Helix Research Network

for Genetic Predisposition to Disease

Sites in Raleigh, Burlington +12 more locations

Sponsor: Helix, Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06057181·Recruiting·Listed Sep 2023

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The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

Sites in Chapel Hill +17 more locations

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting·Listed Jul 2020

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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for Solid Tumor Malignancies

Sites in Huntersville +12 more locations

Sponsor: Tasca Therapeutics

Sex: All·Age: 18+

Code: NCT07030257·Phase 1, Phase 2·Recruiting·Listed Jun 2025

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Study of SGR-1505 in Mature B-Cell Neoplasms

for Mature B-Cell Neoplasm

Sites in Durham +15 more locations

Sponsor: Schrödinger, Inc.

Sex: All·Age: 18+

Code: NCT05544019·Phase 1·Recruiting·Listed Sep 2022

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A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

Sites in Charlotte +12 more locations

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

for Advanced Solid Tumor

Sites in Durham +20 more locations

Sponsor: Clasp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06778863·Phase 1·Recruiting·Listed Jan 2025

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

Sites in Charlotte +18 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting·Listed Oct 2021

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A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia (CARDINAL)

for Chronic Myeloid Leukemia, Chronic Phase

Sites in Winston-Salem +17 more locations

Sponsor: Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Sex: All·Age: 18+

Code: NCT06163430·Phase 1, Phase 2·Recruiting·Listed Dec 2023

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A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

for Crohn's Disease

Sites in Chapel Hill +19 more locations

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06958536·Phase 2·Recruiting·Listed May 2025

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A Study to Assess the Safety and Effectiveness of ELAPR002f Injectable Gel in Adult Participants With Atrophic Acne Scars

for Acne Scars

Sites in Wilmington +9 more locations

Sponsor: AbbVie

Sex: All·Age: 22+

Code: NCT07207369·Phase 3·Recruiting·Listed Oct 2025

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Long-Term Stability of the Glide Control Strategy

for Upper Limb Amputation Above Elbow

Sites in Charlotte +9 more locations

Sponsor: Infinite Biomedical Technologies

Sex: All·Age: 18+

Code: NCT07222085·Recruiting·Listed Oct 2025

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JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Durham +9 more locations

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06108050·Phase 1·Recruiting·Listed Oct 2023

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A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

for Epilepsy, Temporal Lobe

Sites in Durham, Winston-Salem +14 more locations

Sponsor: Neurona Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06422923·Phase 1, Phase 2·Recruiting·Listed May 2024

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Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia (CLL)

Drug: Venetoclax

Sites in Chapel Hill, Winston-Salem +9 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT04895436·Phase 2·Recruiting·Listed May 2021

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

for Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

Sites in Durham +21 more locations

Sponsor: Servier Bio-Innovation LLC

Sex: All·Age: 18+

Code: NCT06127407·Phase 3·Recruiting·Listed Nov 2023

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A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

for Narcolepsy Type 1

Sites in Huntersville, Denver +17 more locations

Sponsor: Takeda

Sex: All·Age: 16 - 70

Code: NCT05816382·Phase 2, Phase 3·Recruiting·Listed Apr 2023

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A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease

for End Stage Renal Disease (ESRD)

Sites in Durham, Charlotte +18 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 90

Code: NCT04671771·Recruiting·Listed Dec 2020

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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

Sites in Durham +10 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting·Listed Jul 2021

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A Phase 1/3 Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

for AML

Sites in Chapel Hill +20 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05473910·Phase 1·Recruiting·Listed Jul 2022

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A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL

for Diabetic Foot Ulcer (DFU)

Sites in Raleigh, Cary +8 more locations

Sponsor: HealthTech Wound Care

Sex: All·Age: 18 - 80

Code: NCT07172893·Phase 4·Recruiting·Listed Sep 2025

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Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia

for Propionic Acidemia

Sites in Durham +10 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: All ages

Code: NCT04159103·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Sites in Durham, Chapel Hill +14 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06747351·Phase 3·Recruiting·Listed Dec 2024

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VALOR: Vaginal Atrophy & Long-term Observation of Recovery

for Atrophic Vaginitis

Sites in Fayetteville +12 more locations

Sponsor: Stratpharma AG

Sex: Female·Age: 18+

Code: NCT05953090·Recruiting·Listed Jul 2023

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Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

for Diabetes

Sites in Concord +19 more locations

Sponsor: Sonavex, Inc.

Sex: All·Age: 18 - 84

Code: NCT06190717·Recruiting·Listed Jan 2024

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Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

for Viral Pneumonia

Sites in Chapel Hill +21 more locations

Sponsor: Synairgen Research Ltd.

Sex: All·Age: 18+

Code: NCT06999603·Phase 2·Recruiting·Listed May 2025

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MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

for Coronary Artery Disease

Sites in Raleigh +23 more locations

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 80

Code: NCT06271590·Recruiting·Listed Feb 2024

Apply to this trial

Exactech Shoulder Post Market Clinical Follow-up Study

for Osteo Arthritis Shoulders

Sites in Durham, Asheville +22 more locations

Sponsor: Exactech

Sex: All·Age: 21+

Code: NCT05603728·Recruiting·Listed Nov 2022

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Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)

for Pulmonary Embolism

Sites in Chapel Hill +12 more locations

Sponsor: Innova Vascular, Inc.

Sex: All·Age: 18 - 85

Code: NCT06041594·Recruiting·Listed Sep 2023

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A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Durham +12 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06859762·Phase 1·Recruiting·Listed Mar 2025

Apply to this trial

CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

for Relapsed/Refractory Acute Myeloid Leukemia (AML)

Sites in Durham +8 more locations

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05143996·Phase 1·Recruiting·Listed Dec 2021

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Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)

for Low Risk Myelodysplastic Syndromes

Sites in Durham +12 more locations

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05308264·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

for Colorectal Cancer

Sites in Goldsboro +19 more locations

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT05234177·Recruiting·Listed Feb 2022

Apply to this trial